Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael Herger"'
Autor:
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellermann, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Antonia Weberling, Clara Munger, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-imp
Externí odkaz:
https://doaj.org/article/19d37a4e6ae24ca8b14f83a6a064a669
Autor:
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellerman, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder
Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs could provide insight into mechanisms underlying mammalian pre-implantatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c741f38e1670e171ebf6a355c63c9f57
https://doi.org/10.1101/2022.03.13.484158
https://doi.org/10.1101/2022.03.13.484158
Splitmix assembly of DNA libraries for ultrahigh throughput on-bead screening of functional proteins
Autor:
Michael Herger, Michael Snaith, Laurens Lindenburg, Florian Hollfelder, Kayleigh van de Wiel, Tuomas Huovinen
Publikováno v:
Nucleic Acids Research
Site-saturation libraries reduce protein screening effort in directed evolution campaigns by focusing on a limited number of rationally chosen residues. However, uneven library synthesis efficiency leads to amino acid bias, remedied at high cost by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac37768959493ead79a38512ea07a32
https://pubmed.ncbi.nlm.nih.gov/32383757
https://pubmed.ncbi.nlm.nih.gov/32383757
Autor:
Michael Herger, Remkes A. Scheele, Paul van Roye, Jackson K. B. Cahn, Andrew R. Buller, Frances H. Arnold
Allosteric enzymes contain a wealth of catalytic diversity that remains distinctly underutilized for biocatalysis. Tryptophan synthase is a model allosteric system and a valuable enzyme for the synthesis of non-canonical amino acids (ncAA). Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7501e285cf94da9276afe63041af62d6
https://resolver.caltech.edu/CaltechAUTHORS:20180501-112938311
https://resolver.caltech.edu/CaltechAUTHORS:20180501-112938311
Publikováno v:
Journal of the American Chemical Society. 140(2)
Self-assembling protein cages are useful as nanoscale molecular containers for diverse applications in biotechnology and medicine. To expand the utility of such systems, there is considerable interest in customizing the structures of natural cage-for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fbdb2bb5d755045d47eb7c715cabfa
https://pubmed.ncbi.nlm.nih.gov/29257675
https://pubmed.ncbi.nlm.nih.gov/29257675
Publikováno v:
Pharmaceutical Research, 31 (12)
Pharmaceutical Research
Pharmaceutical Research
The membrane protein P-glycoprotein (P-gp) plays key roles in the oral bioavailability of drugs, their blood brain barrier passage as well as in multidrug resistance. For new drug candidates it is mandatory to study their interaction with P-gp, accor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fbfd8b56fb4391e62cf5641bd12500
https://doi.org/10.1007/s11095-014-1431-2
https://doi.org/10.1007/s11095-014-1431-2
Autor:
Sabine Brinkmann-Chen, Andrew R. Buller, Michael Herger, Frances H. Arnold, Paul van Roye, David K. Romney
We report that l-threonine may substitute for l-serine in the β-substitution reaction of an engineered subunit of tryptophan synthase from Pyrococcus furiosus, yielding (2S,3S)-β-methyltryptophan (β-MeTrp) in a single step. The trace activity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16c6bacd9806357daea62114acd90c9
https://europepmc.org/articles/PMC4948191/
https://europepmc.org/articles/PMC4948191/
Autor:
Michael Herger, Andrew R. Buller, Frances H. Arnold, Javier Murciano-Calles, Sabine Brinkmann-Chen, David K. Romney
Many enzymes perform desirable biochemical transformations, but are not suitable to use as biocatalysts outside of the cell. In particular, enzymes from heteromeric complexes typically have decreased activity when removed from their protein partners.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b01146a5dddbb0d399b4bc5c5d6595a
https://europepmc.org/articles/PMC4664345/
https://europepmc.org/articles/PMC4664345/