Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael Hepperle"'
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08a9d0f42ee2ca716c95dae1022f1b7
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb79
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb79
Autor:
Dean Messing, Win Naing, Joseph P. Portanova, Tina Kim, Alan G. Benson, Shaun R. Selness, Daniel L. Flynn, Joseph B. Monahan, Richard Lindmark, Huey S. Shieh, John K. Walker, Syaulan Yang, Ravi Kurambail, Rajesh V. Devraj, Michael Hepperle, Dice Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2634-2638
Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c566e95d1288f02e436717a89b88f0f9
https://doi.org/10.1016/j.bmcl.2010.02.047
https://doi.org/10.1016/j.bmcl.2010.02.047
Autor:
Jeffrey L. Hirsch, Robert H. Keith, Loreen Stillwell, Pamela De Ciechi, Jian Zhang, Ravi G. Kurumbail, Richard M. Leimgruber, Shaun R. Selness, Huey S. Shieh, Stephen J. Mnich, Yan Zhang, Barry L. Burnette, Michael Hepperle, Robert P. Compton, Raj Devraj, Gail Jungbluth, Win Naing, Joseph B. Monahan, Joseph Portanova, Gary D. Anderson, Heidi R. Hope
Publikováno v:
Pharmacology. 84:42-60
SD0006 is a diarylpyrazole that was prepared as an inhibitor of p38 kinase-alpha (p38alpha). In vitro, SD0006 was selective for p38alpha kinase over 50 other kinases screened (including p38gamma and p38delta with modest selectivity over p38beta). Cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417af8711e84292fd44a13daf8ddc013
https://doi.org/10.1159/000227286
https://doi.org/10.1159/000227286
Autor:
Lloyd T. Lam, R. Eric Davis, Jackie Pierce, Michael Hepperle, Yajun Xu, Maria Hottelet, Yuhua Nong, Danyi Wen, Julian Adams, Lenny Dang, Louis M. Staudt
Publikováno v:
Clinical Cancer Research. 11:28-40
Constitutive activation of the NF-κB pathway is required for survival of the activated B cell–like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL). Here we show that a small molecule IκB kinase (IKK) inhibitor, PS-1145, and related compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba983b67e3b984d5dc5413ec873032c4
https://doi.org/10.1158/1078-0432.28.11.1
https://doi.org/10.1158/1078-0432.28.11.1
Autor:
C. Anderson Evans, Dinesh Gala, Andrew J. Goodman, Lan Shen, Michael Hepperle, Jeffrey M. Eckert
Publikováno v:
Tetrahedron Letters. 43:3359-3363
A novel application of Pd 0 -catalyzed arylation to mono N -arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N , N ′-diarylated piperazine antifungal intermediate N -(4-hydroxyphenyl)- N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::626646dd46c59e35c694f539cbc90882
https://doi.org/10.1016/s0040-4039(02)00556-7
https://doi.org/10.1016/s0040-4039(02)00556-7
Publikováno v:
Tetrahedron Letters. 40:5655-5659
A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N,N′-biarylated piperazine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d86ae16f8bd7cbb42e31aed2c55601c
https://doi.org/10.1016/s0040-4039(99)01103-x
https://doi.org/10.1016/s0040-4039(99)01103-x
Publikováno v:
ChemInform. 30
A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N,N′-biarylated piperazine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5289a5a9d80b23c334cf3b58f48ed94c
https://doi.org/10.1002/chin.199940133
https://doi.org/10.1002/chin.199940133
Autor:
C. Anderson Evans, Michael Hepperle, Jeffrey M. Eckert, Lan Shen, Andrew J. Goodman, Dinesh Gala
Publikováno v:
ChemInform. 33
A novel application of Pd 0 -catalyzed arylation to mono N -arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N , N ′-diarylated piperazine antifungal intermediate N -(4-hydroxyphenyl)- N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da63baa21a588c8b4b8b80a261c435f
https://doi.org/10.1002/chin.200234175
https://doi.org/10.1002/chin.200234175
Autor:
Alan G. Benson, John E. Baldus, Michael Hepperle, Li Xing, Kevin D. Jerome, Shaun R. Selness, John K. Walker, Rajesh V. Devraj
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
The synthesis, structure–activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38α inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89beae325fb9ce985dc7c72822c83ce
https://pubmed.ncbi.nlm.nih.gov/20395140
https://pubmed.ncbi.nlm.nih.gov/20395140
Autor:
Gunda I. Georg, Geraldine C. B. Harriman, David G. Vander Velde, Thomas C. Boge, Zacharia S. Cheruvallath, Apurba Datta, Michael Hepperle, Haeil Park, Richard H. Himes, Lalith Jayasinghe
Publikováno v:
ACS Symposium Series ISBN: 9780841230736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4013f3cd80d71dd63b06e1a350630b
https://doi.org/10.1021/bk-1995-0583.ch016
https://doi.org/10.1021/bk-1995-0583.ch016
