Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Michael Hayden"'
Autor:
Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan, Kari J. Wiedinger, Wencheng Li, Kerstin A. Effenberger, Matthew G. Woll, Minakshi B. Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M. Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A. Naryshkin, Jason D. Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M. Colacino, Stuart W. Peltz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here the authors describe the discovery of a class of small molecule splicing modifiers which are orally bioavailable, cross the blood-brain barrier, and lower levels of huntingtin in a mouse model of Huntington’s disease (HD).
Externí odkaz:
https://doaj.org/article/7d4bfc4e0c074bdc9d52a1e84c8c63c4
Autor:
Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102424- (2022)
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and
Externí odkaz:
https://doaj.org/article/41a596c6e228444184c1c9a70b5c8a8a
Autor:
Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc
Externí odkaz:
https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75
Autor:
Daniel Ryskamp, Lili Wu, Jun Wu, Dabin Kim, Gerhard Rammes, Michal Geva, Michael Hayden, Ilya Bezprozvanny
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 489-504 (2019)
There is evidence that cognitive decline in Alzheimer's disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped ‘memory spines’) and neurodegenerative processes. This might be treated with sigma-1 receptor
Externí odkaz:
https://doaj.org/article/6953cb1de75b4d04b83905862aabbe9f
Autor:
Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny
Publikováno v:
Neurobiology of Disease, Vol 97, Iss , Pp 46-59 (2017)
The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no di
Externí odkaz:
https://doaj.org/article/9663a4e2c25e4386a5bcd97f7b718930
Autor:
Franz Rinninger, Markus Heine, Roshni Singaraja, Michael Hayden, May Brundert, Rajasekhar Ramakrishnan, Joerg Heeren
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1914-1924 (2014)
The LDL receptor (LDLR) and scavenger receptor class B type I (SR-BI) play physiological roles in LDL and HDL metabolism in vivo. In this study, we explored HDL metabolism in LDLR-deficient mice in comparison with WT littermates. Murine HDL was radio
Externí odkaz:
https://doaj.org/article/e1b36cb55d634d58b941da10122febd7
Publikováno v:
Issues in Information Systems, Vol 11, Iss 1, Pp 256-265 (2010)
Externí odkaz:
https://doaj.org/article/1328ba179f1a4b79bbd69be4c80d32e5
Autor:
Janet Prichard, Michael Hayden
Publikováno v:
Issues in Information Systems, Vol 9, Iss 2, Pp 452-459 (2008)
Externí odkaz:
https://doaj.org/article/9f14d59f61b14ee3b70f739209eab568
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease
Autor:
Shotaro Kishikawa, Jian-Liang Li, Tammy Gillis, Michael M. Hakky, Simon Warby, Michael Hayden, Marcy E. MacDonald, Richard H. Myers, James F. Gusella
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 280-285 (2006)
In Huntington’s disease (HD), genetic factors in addition to the HD CAG repeat mutation play a significant role in determining age at neurologic onset. Brain-derived neurotrophic factor (BDNF), a survival factor for striatal neurons, has been impli
Externí odkaz:
https://doaj.org/article/4036132fd5ae4c62967a013d27cf7867
Autor:
J. Michael Hayden
The Catholicisms of Coutances is a richly detailed account of France from the Hundred Years'War to the French revolution. Coining the word'catholicisms'to denote the complex varieties of religious beliefs and practices within the Church, J. Michael H