Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael Haugbro"'
Autor:
Jeffrey A. Schneider, Timothy W. Craven, Amanda C. Kasper, Chi Yun, Michael Haugbro, Erica M. Briggs, Vladimir Svetlov, Evgeny Nudler, Holger Knaut, Richard Bonneau, Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of W
Externí odkaz:
https://doaj.org/article/3c5aea308e6d452390e2d44fcb37b64b
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
Development of resistance to antiandrogens for treating advanced prostate cancer is a growing concern and extends to recently developed therapeutics, including enzalutamide. Therefore, new strategies to block androgen receptor (AR) function in prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9faf706199423a4796009a5c110da5a9
https://doi.org/10.1158/0008-5472.c.6508194.v1
https://doi.org/10.1158/0008-5472.c.6508194.v1
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
Primer sequences for qRT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906527970707a30c62142ca681d2855
https://doi.org/10.1158/0008-5472.22411314.v1
https://doi.org/10.1158/0008-5472.22411314.v1
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
MPC6 inhibits AR transcriptional activity (S1); MPC6 treatment did not decrease AR protein level in prostate cancer cell lines (S2); MPC6's anti-proliferative effect in non-prostate cancer cell lines (S3); PK/PD analysis for plasma MPC6 concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61ca73741d70ea8fdb21dadc1554c0e
https://doi.org/10.1158/0008-5472.22411320
https://doi.org/10.1158/0008-5472.22411320
Publikováno v:
Nature Chemistry. 12:520-527
Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining such interactomes will enable the study of how perturbations of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b923cfd8e34b53bddeed7350b72c634
https://doi.org/10.1038/s41557-020-0474-8
https://doi.org/10.1038/s41557-020-0474-8
Publikováno v:
Proc Natl Acad Sci U S A
Split inteins are privileged molecular scaffolds for the chemical modification of proteins. Though efficient for in vitro applications, these polypeptide ligases have not been utilized for the semisynthesis of proteins in live cells. Here, we biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a952c6ec398ea37fb4f1552b19aa0b2
https://pubmed.ncbi.nlm.nih.gov/32424098
https://pubmed.ncbi.nlm.nih.gov/32424098
Autor:
Michael Haugbro, Kent Kirshenbaum, Evgeny Nudler, Richard Bonneau, Holger Knaut, Michael J. Garabedian, Jeffrey A. Schneider, Vladimir Svetlov, Chi Yun, Susan K. Logan, Erica M. Briggs, Timothy W. Craven, Amanda C. Kasper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
New chemical inhibitors of protein–protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit protein-protein interactions by mimicking protein secondary struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8451aa8c7e2155f16e472468775a88
http://link.springer.com/article/10.1038/s41467-018-06845-3
http://link.springer.com/article/10.1038/s41467-018-06845-3
Autor:
Antony J, Burton, Michael, Haugbro, Leah A, Gates, John D, Bagert, C David, Allis, Tom W, Muir
Publikováno v:
Nature chemistry. 12(6)
Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining such interactomes will enable the study of how perturbations of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4b7a584e2d5c406c0d9ac57256063c1
https://pubmed.ncbi.nlm.nih.gov/32472102
https://pubmed.ncbi.nlm.nih.gov/32472102
Autor:
Mark Esposito, Xiaoyang Su, David H. Perlman, Joshua D. Rabinowitz, Yael David, Michael Haugbro, Rob C. Oslund, Jung-Min Kee, Yibin Kang, Eva J. Ge, Tom W. Muir, Boyuan Wang
Publikováno v:
Nature chemical biology
Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2f8f053d7b7bfb5fa2ff7b1a67d115
https://doi.org/10.1038/nchembio.2453
https://doi.org/10.1038/nchembio.2453