Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity

Autor: Martin Bidlingmaier, Antônio Ribeiro-Oliveira, Júnia R O L Schweizer, Sylvère Störmann, Mariana F Bizzi, Beatriz Santana Soares, Jochen Schopohl, Michael Haenelt, Alexandre Varella Giannetti, Katharina Schilbach, Eduardo Paulino

Publikováno v: The Journal of Clinical Endocrinology and Metabolism

Context Soluble alpha klotho (sαKL) has been linked to growth hormone (GH) action, but systematic evaluation and comparisons with traditional biomarkers in acromegaly are lacking. Objective To evaluate the potential of sαKL to aid classification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74d2284464caf4c833528c6ea2b2168
http://europepmc.org/articles/PMC8277223

Soluble alpha klotho in adult patients with growth hormone deficiency

Autor: de Oliveira Longo Schweizer Junia Ribeiro, Katharina Schilbach, Michael Haenelt, Anica Gagliardo, Sylvere Stormann, Jochen Schopohl, Martin Bidlingmaier

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c855c5998121ed444a4761fb8326fc7
https://doi.org/10.1530/endoabs.81.p660

MON-327 Soluble Alpha Klotho and IGF-I Before Surgery as Prognostic Factors to Acromegaly Long-term Remission

Autor: Junia Ribeiro de Oliveira Longo Schweizer, Mariana F Bizzi, Martin Bidlingmaier, Sylvere Stoermann, Katharina Schilbach, Antonio Ribeiro-Oliveira, Beatriz Santana Soares Rocha, Jochen Schopohl, Michael Haenelt, Alexandre Varella Giannetti, Xiao Wang

Publikováno v: Journal of the Endocrine Society

BACKGROUND: Transsphenoidal surgery is the cornerstone of acromegaly treatment. However, cure is obtained in only ~50% of the cases. Until today, no biochemical marker has been identified to preoperatively predict surgical outcome and long-term remis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01fe800de30cfe2b9ecad0098dd2a69
http://europepmc.org/articles/PMC7208593

SUN-LB61 Differential and Opposite Regulation of Acid Labile Subunit (ALS) Versus Insulin-Like Growth Factor I (IGF-I) by Oral Estrogens in Premenopausal Women

Autor: Sarina Benedix, Michael Haenelt, Shiva Sophia Nicolay, Rita Schwaiger, Martin Bidlingmaier, Junia Ribeiro de Oliveira Longo Schweizer, Katharina Schilbach, Sylvère Störmann, Laura Schwerdt, Jochen Schopohl

Publikováno v: Journal of the Endocrine Society

Background: The impact of estrogens (E2) on the growth hormone (GH)/IGF-I axis is known to depend on route of administration: While oral E2 increases GH and decreases IGF-I, transdermal E2 has only limited or no effect. However, data concerning the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f571489085174f299cde1ebab97159e
https://doi.org/10.1210/jendso/bvaa046.2276

Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults

Autor: Jochen Schopohl, Michael Haenelt, Andreas Lechner, Christina Gar, Katharina Schilbach, Sylvère Störmann, Jakob Dal, Laura Schwerdt, Shiva Sophia Nicolay, J. O. L. Jørgensen, Martin Bidlingmaier

Publikováno v: Schilbach, K, Gar, C, Lechner, A, Nicolay, S S, Schwerdt, L, Haenelt, M, Dal, J, Jorgensen, J O L, Störmann, S, Schopohl, J & Bidlingmaier, M 2019, ' Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults ', European Journal of Endocrinology, vol. 181, no. 1, pp. 55-67 . https://doi.org/10.1530/EJE-19-0139

Objective Growth hormone (GH) nadir (GHnadir) during oral glucose tolerance test (OGTT) is an important tool in diagnosing acromegaly, but data evaluating the need to adjust cut-offs to biological variables utilizing today's assay methods are scarce.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e25225dc1835b2ef08ab09792e7d4
https://vbn.aau.dk/da/publications/aa3283be-7943-42df-b63f-db0a49ebad92