Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity

Autor: Martin Bidlingmaier, Antônio Ribeiro-Oliveira, Júnia R O L Schweizer, Sylvère Störmann, Mariana F Bizzi, Beatriz Santana Soares, Jochen Schopohl, Michael Haenelt, Alexandre Varella Giannetti, Katharina Schilbach, Eduardo Paulino

Publikováno v: The Journal of Clinical Endocrinology and Metabolism

Context Soluble alpha klotho (sαKL) has been linked to growth hormone (GH) action, but systematic evaluation and comparisons with traditional biomarkers in acromegaly are lacking. Objective To evaluate the potential of sαKL to aid classification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74d2284464caf4c833528c6ea2b2168
http://europepmc.org/articles/PMC8277223

Soluble alpha klotho in adult patients with growth hormone deficiency

Autor: de Oliveira Longo Schweizer Junia Ribeiro, Katharina Schilbach, Michael Haenelt, Anica Gagliardo, Sylvere Stormann, Jochen Schopohl, Martin Bidlingmaier

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c855c5998121ed444a4761fb8326fc7
https://doi.org/10.1530/endoabs.81.p660

SUN-LB62 Differential Regulation of 22 kDa and 20 kDa Growth Hormone Isoforms in Response to Acute Glucose Load and Moderate Intensity Exercise

Autor: Michael Haenelt, Katharina Schilbach, Lechner Andreas, Martin Bidlingmaier, Junia Ribeiro de Oliveira Longo Schweizer, Shiva Sophia Nicolay, Christina Gar

Publikováno v: Journal of the Endocrine Society

Background: Among growth hormone (GH) isoforms, the 22kDa (22kD) is the most abundant (~90%), followed by 20 kDa GH ((20kD) ~10%). 22kD has known diabetogenic potential by increasing insulin resistance. Although of equal somatotropic activity, 20kD h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22037b16d50bf0268f7d4d42e0e4dcae
http://europepmc.org/articles/PMC7209317

SUN-LB61 Differential and Opposite Regulation of Acid Labile Subunit (ALS) Versus Insulin-Like Growth Factor I (IGF-I) by Oral Estrogens in Premenopausal Women

Autor: Sarina Benedix, Michael Haenelt, Shiva Sophia Nicolay, Rita Schwaiger, Martin Bidlingmaier, Junia Ribeiro de Oliveira Longo Schweizer, Katharina Schilbach, Sylvère Störmann, Laura Schwerdt, Jochen Schopohl

Publikováno v: Journal of the Endocrine Society

Background: The impact of estrogens (E2) on the growth hormone (GH)/IGF-I axis is known to depend on route of administration: While oral E2 increases GH and decreases IGF-I, transdermal E2 has only limited or no effect. However, data concerning the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f571489085174f299cde1ebab97159e
https://doi.org/10.1210/jendso/bvaa046.2276

Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults

Autor: Jochen Schopohl, Michael Haenelt, Andreas Lechner, Christina Gar, Katharina Schilbach, Sylvère Störmann, Jakob Dal, Laura Schwerdt, Shiva Sophia Nicolay, J. O. L. Jørgensen, Martin Bidlingmaier

Publikováno v: Schilbach, K, Gar, C, Lechner, A, Nicolay, S S, Schwerdt, L, Haenelt, M, Dal, J, Jorgensen, J O L, Störmann, S, Schopohl, J & Bidlingmaier, M 2019, ' Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults ', European Journal of Endocrinology, vol. 181, no. 1, pp. 55-67 . https://doi.org/10.1530/EJE-19-0139

Objective Growth hormone (GH) nadir (GHnadir) during oral glucose tolerance test (OGTT) is an important tool in diagnosing acromegaly, but data evaluating the need to adjust cut-offs to biological variables utilizing today's assay methods are scarce.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e25225dc1835b2ef08ab09792e7d4
https://vbn.aau.dk/da/publications/aa3283be-7943-42df-b63f-db0a49ebad92