Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Michael Habeck"'
Autor:
Vanessa Lopes-Rodrigues, Pia Boxy, Eunice Sim, Dong Ik Park, Michael Habeck, Josep Carbonell, Annika Andersson, Diana Fernández-Suárez, Poul Nissen, Anders Nykjær, Lilian Kisiswa
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-13 (2023)
Abstract Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death i
Externí odkaz:
https://doaj.org/article/4188c53e5bda44dd986f66f416d2e3a1
Autor:
Hafiza Nosheen Saleem, Nadezda Ignatyeva, Christiaan Stuut, Stefan Jakobs, Michael Habeck, Antje Ebert
Publikováno v:
Cells, Vol 13, Iss 11, p 923 (2024)
Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic nature of the endosome network pr
Externí odkaz:
https://doaj.org/article/3b730f7ae6354b759a23f3445aeabccb
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Conformational transitions are implicated in the biological function of many proteins. Structural changes in proteins can be described approximately as the relative movement of rigid domains against each other. Despite previous ef
Externí odkaz:
https://doaj.org/article/5f1cdf7db82b45549cf8766bb808ad3e
Autor:
Maximilian Zinke, Katrin A. A. Sachowsky, Carl Öster, Sophie Zinn-Justin, Raimond Ravelli, Gunnar F. Schröder, Michael Habeck, Adam Lange
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Bacteriophages of the Siphoviridae family have a long, flexible, non-contractile tail that has been difficult to characterize structurally. Here, the authors present the atomic structure of the tail tube of one of these phages, showing a hollow flexi
Externí odkaz:
https://doaj.org/article/62511668bbbc4a978e77f31884983fd0
Autor:
Nima Vakili, Michael Habeck
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Random tomography is a common problem in imaging science and refers to the task of reconstructing a three-dimensional volume from two-dimensional projection images acquired in unknown random directions. We present a Bayesian approach to random tomogr
Externí odkaz:
https://doaj.org/article/df9b732246d84b58868b666fb3253136
Autor:
Janelle Lauer, Sandra Segeletz, Alice Cezanne, Giambattista Guaitoli, Francesco Raimondi, Marc Gentzel, Vikram Alva, Michael Habeck, Yannis Kalaidzidis, Marius Ueffing, Andrei N Lupas, Christian Johannes Gloeckner, Marino Zerial
Publikováno v:
eLife, Vol 8 (2019)
Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rab
Externí odkaz:
https://doaj.org/article/59c0b315ce7c4837876fc46fb806c8fa
Autor:
Yi-Ling Chen, Michael Habeck
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183057 (2017)
Advances in experimental and computational techniques allow us to study the structure and dynamics of large biomolecular assemblies at increasingly higher resolution. However, with increasing structural detail it can be challenging to unravel the mec
Externí odkaz:
https://doaj.org/article/b6b54d77360446cebc418b0e47214179
Autor:
Marcin Michalik, Marcella Orwick-Rydmark, Michael Habeck, Vikram Alva, Thomas Arnold, Dirk Linke
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182016 (2017)
An intimate interaction between a pair of amino acids, a tyrosine and glycine on neighboring β-strands, has been previously reported to be important for the structural stability of autotransporters. Here, we show that the conservation of this intera
Externí odkaz:
https://doaj.org/article/0ceb679875ca45818a1d4df7b61e7f44
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005292 (2016)
Chromosome conformation capture (3C) techniques have revealed many fascinating insights into the spatial organization of genomes. 3C methods typically provide information about chromosomal contacts in a large population of cells, which makes it diffi
Externí odkaz:
https://doaj.org/article/f272566b22404d88b3ed788c2f40b5c6
Autor:
Martin Mechelke, Michael Habeck
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100197 (2014)
The use of statistical potentials in NMR structure calculation improves the accuracy of the final structure but also raises issues of double counting and possible bias. Because statistical potentials are averaged over a large set of structures, they
Externí odkaz:
https://doaj.org/article/7f7cf8fb253e4af28a1ae3ac72eb1d20