Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael H. Roehrl"'
Autor:
Makiko Ogawa, Atsushi Tanaka, Masaki Maekawa, Kei Namba, Yusuke Otani, Jinru Shia, Julia Y. Wang, Michael H. Roehrl
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/edf9223ec7c845cab29318c3d88d890c
Autor:
Fergus Keane, Raazi Bajwa, Pier Selenica, Wungki Park, Michael H. Roehrl, Jorge S. Reis-Filho, Diana Mandelker, Eileen M. O’Reilly
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Poorly differentiated pancreatic neuroendocrine tumors (PDNEC), are a subtype of pancreatic cancer encompassing both small cell and large cell neuroendocrine carcinoma subtypes, and are characterized as distinct in terms of biology and progn
Externí odkaz:
https://doaj.org/article/190db58c7ab44bb79fe3e0deef0cefb6
Autor:
Rebecca Caeser, Jacklynn V. Egger, Shweta Chavan, Nicholas D. Socci, Caitlin Byrne Jones, Faruk Erdem Kombak, Marina Asher, Michael H. Roehrl, Nisargbhai S. Shah, Viola Allaj, Parvathy Manoj, Sam E. Tischfield, Amanda Kulick, Maximiliano Meneses, Christine A. Iacobuzio-Donahue, W. Victoria Lai, Umeshkumar Bhanot, Marina K. Baine, Natasha Rekhtman, Travis J. Hollmann, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Creating accurate models of small cell lung cancer is essential to ensure the clinical relevance of results. Here, the authors create patient derived xenograft models from 33 patients and show, through multi-omics sequencing, that these models retain
Externí odkaz:
https://doaj.org/article/6db844e570e04ea595ba52c8f6bba923
Autor:
Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jordana Ray-Kirton, Jacklynn D. Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Katia Ventura, Juan Qiu, Elisa de Stanchina, Jason C. Chang, Natasha Rekhtman, Brian Houck-Loomis, Richard P. Koche, Helena A. Yu, Triparna Sen, Charles M. Rudin
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon includes small cell and squamous cell (LUSC
Externí odkaz:
https://doaj.org/article/4c6ed1ab46b04936a848bae9af7bc67d
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Colorectal adenocarcinomas arise from luminal lining epithelium of the colorectal tract which is covered with highly glycosylated mucins. Mucin O-glycosylation is initiated by a family of polypeptide N-acteylgalactosaminyltransferases (GALNTs). This
Externí odkaz:
https://doaj.org/article/42ffb53e5c4b413fb53ab985c2f39d8f
Autor:
Atsushi Tanaka, Julia Y. Wang, Jinru Shia, Yihua Zhou, Makiko Ogawa, Ronald C. Hendrickson, David S. Klimstra, Michael H. Roehrl
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract DEAD-box RNA helicase DDX21 (also named nucleolar RNA helicase 2) is a nuclear autoantigen with undefined roles in cancer. To explore possible roles of autoimmune recognition in cancer immunity, we examined DDX21 protein expression in colore
Externí odkaz:
https://doaj.org/article/c2c9bb8563534cf2977d98f7085af19d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells. DS-autoAg complexe
Externí odkaz:
https://doaj.org/article/451ebcfe265d499c9a1b1bc23825c34a
Publikováno v:
Journal of Translational Autoimmunity, Vol 5, Iss , Pp 100147- (2022)
Chronic and debilitating autoimmune sequelae pose a grave concern for the post-COVID-19 pandemic era. Based on our discovery that the glycosaminoglycan dermatan sulfate (DS) displays peculiar affinity to apoptotic cells and autoantigens (autoAgs) and
Externí odkaz:
https://doaj.org/article/da73953f9ffe4a1cbb7874c75cb5042c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dermatan sulfate (DS) and autoantigen (autoAg) complexes are capable of stimulating autoreactive CD5+ B1 cells. We examined the activity of DS on CD5+ pre-B lymphoblast NFS-25 cells. CD19, CD5, CD72, PI3K, and Fas possess varying degrees of DS affini
Externí odkaz:
https://doaj.org/article/76bab6c145ac45978d563be8681627f9
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can induce similar autoimmu
Externí odkaz:
https://doaj.org/article/9a5bdbd46b364ff78c6afb341c7f8cec