Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael H. Lai"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits. Anothe
Externí odkaz:
https://doaj.org/article/81d0a7367dca4a45ad95a4bd693569f4
Autor:
Xiaobing Yu, Amy N. Ton, Zejun Niu, Blanca M. Morales, Jiadong Chen, Joao Braz, Michael H. Lai, Emilie Barruet, Hongju Liu, Kin Cheung, Syed Ali, Tea Chan, Katherine Bigay, Jennifer Ho, Ina Nikolli, Steven Hansberry, Kelly Wentworth, Arnold Kriegstein, Allan Basbaum, Edward C. Hsiao
Publikováno v:
Pain, vol 164, iss 1
Altered bone morphogenetic protein (BMP) signaling is associated with many musculoskeletal diseases. However, it remains unknown whether BMP dysfunction has direct contribution to debilitating pain reported in many of these disorders. Here, we identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c03e99d9684138120634016a9d8fca
https://doi.org/10.1097/j.pain.0000000000002656
https://doi.org/10.1097/j.pain.0000000000002656
Autor:
Michael H. Lai, Andrew P. Blair, Oriane B. Matthys, David A Joy, Benoit G. Bruneau, Michael Alexanian, Ana C. Silva, Mara A. Kauss, Todd C. McDevitt, Vaishaali Natarajan, Diwaker Turaga
Publikováno v:
Cell stem cell. 28(12)
Summary During embryogenesis, paracrine signaling between tissues in close proximity contributes to the determination of their respective cell fate(s) and development into functional organs. Organoids are in vitro models that mimic organ formation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343221e987e52b8c555cc2881f094539
https://pubmed.ncbi.nlm.nih.gov/34861142
https://pubmed.ncbi.nlm.nih.gov/34861142
Autor:
Benoit G. Bruneau, Vaishaali Natarajan, Ana C. Silva, Michael Alexanian, Michael H. Lai, David A Joy, Diwakar Turaga, M.A. Kauss, Todd C. McDevitt, Oriane B. Matthys
During embryogenesis, paracrine signaling between tissues in close proximity contributes to the determination of their respective cell fate(s) and development into functional organs. Organoids arein vitromodels that mimic organ formation and cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1128982dcd466d9d4e27b864f14b15
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits. Anothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f93c777531496cfe661736fdc23f53
https://doi.org/10.3389/fnmol.2019.00285
https://doi.org/10.3389/fnmol.2019.00285
Autor:
Reuben Thomas, Giovanni Iacono, Fei Gu, W. Patrick Devine, Tatyana Sukonnik, Bayardo I. Garay, Christine E. Seidman, Jonathan G. Seidman, Kai Li, Kavitha S. Rao, Benoit G. Bruneau, Henry Gong, Swetansu K. Hota, Irfan S. Kathiriya, William T. Pu, Andrew Blair, Piyush Goyal, Brynn N. Akerberg, Lauren K. Wasson, Laure D. Bernard, Gunes A. Akgun, Michael H. Lai, Holger Heyn, Joshua M. Stuart
Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD). However, underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD-link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144b266e50ebe14cdac357f176f3364b
https://doi.org/10.1101/835603
https://doi.org/10.1101/835603
Autor:
Tatyana Sukonnik, Fei Gu, Maximilian Haeussler, W. Patrick Devine, Reuben Thomas, Kavitha S. Rao, Michael H. Lai, Matthew L. Speir, William T. Pu, Irfan S. Kathiriya, Piyush Goyal, Bayardo I. Garay, Jonathan G. Seidman, Kai Li, Swetansu K. Hota, Andrew Blair, Benoit G. Bruneau, Henry Gong, Laure D. Bernard, Gunes A. Akgun, Holger Heyn, Lauren K. Wasson, Joshua M. Stuart, Giovanni Iacono, Kevin M. Hu, Brynn N. Akerberg, Christine E. Seidman
Publikováno v:
Dev Cell
Developmental cell, vol 56, iss 3
Developmental cell, vol 56, iss 3
Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355dc6ae49133bf02d2f38d8f2d4b43
https://doi.org/10.1016/j.devcel.2020.11.020
https://doi.org/10.1016/j.devcel.2020.11.020
Autor:
Jim Reid, Gunter Hartel, William J. H. McBride, Leon Heron, William D. Rawlinson, Ian G. Barr, Simon Carson, Walter P. Abhayaratna, Jonathan R. Carapetis, Ferdinandus de Looze, Michael H. Lai, Sepehr Shakib, Helen Marshall, Rod Ellis-Pegler, Russell L. Basser, Jodie McVernon, Steven Rockman, Terry Nolan, Robert Booy, Michael Greenberg, Jeff Karrasch, Peter Richmond
Publikováno v:
Vaccine. 34:4991-4997
Background Before pandemic H1N1 vaccines were available, the potential benefit of existing seasonal trivalent inactivated influenza vaccines (IIV3s) against influenza due to the 2009 pandemic H1N1 influenza strain was investigated, with conflicting r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d96a699980c2a9f6deac671a5c2449e
https://doi.org/10.1016/j.vaccine.2016.08.038
https://doi.org/10.1016/j.vaccine.2016.08.038
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H1327-H1338
Large-conductance Ca2+- and voltage-activated K+ (BK) channels play prominent roles in shaping muscle and neuronal excitability. In the cardiovascular system, BK channels promote vascular relaxation and protect against ischemic injury. Recently, inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71605bb7699b52f732de54433d3ec7b
https://doi.org/10.1152/ajpheart.00354.2014
https://doi.org/10.1152/ajpheart.00354.2014
Publikováno v:
American Journal of Physiology-Cell Physiology. 304:C299-C311
In mammals, almost all aspects of circadian rhythmicity are attributed to activity in a discrete neural circuit of the hypothalamus, the suprachiasmatic nucleus (SCN). A 24-h rhythm in spontaneous firing is the fundamental neural intermediary to circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11751bf090e522f5722c2c81caab792
https://doi.org/10.1152/ajpcell.00302.2012
https://doi.org/10.1152/ajpcell.00302.2012