Výsledky vyhledávání - "Michael H. George"

Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice

Autor: Leah C. Wehmas, Sandra R. Eldridge, Julia H. Carter, Charles E. Wood, Michael H. George, Beena Vallanat, Anna Fisher, Gleta Carswell, Anthony B. DeAngelo, Greg R. Olson, Brian N. Chorley, Susan D. Hester

Publikováno v: Toxicological Sciences. 159:354-365

Early-life environmental factors can influence later-life susceptibility to cancer. Recent evidence suggests that metabolic pathways may mediate this type of latency effect. Previously, we reported that short-term exposure to dichloroacetic acid (DCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb87b3811ecc11a315a7b059c8a1fc2
https://doi.org/10.1093/toxsci/kfx146

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Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice

Autor: Susan D. Hester, Elias T. Gaillard, Tanya Moore, Michael H. George, Charles E. Wood, William O. Ward, Carlin Okerberg, Anthony B. DeAngelo, Anna Fisher, Brian N. Chorley, April D. Lake, Hongzu Ren, Gleta Carswell, Beena Vallanat

Publikováno v: Carcinogenesis. 36:782-791

Environmental exposures occurring early in life may have an important influence on cancer risk later in life. Here, we investigated carryover effects of dichloroacetic acid (DCA), a small molecule analog of pyruvate with metabolic programming propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039d62494e0a2953649a5fa06d27d195
https://doi.org/10.1093/carcin/bgv057

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Reproductive Toxicity of a Mixture of Regulated Drinking-Water Disinfection By-Products in a Multigenerational Rat Bioassay

Autor: Jane Ellen Simmons, Jerome M. Goldman, Anthony B. DeAngelo, Deborah S. Best, E. Sidney Hunter, Juan D. Suarez, Michael H. George, Anthony McDonald, Michael G. Narotsky, Ashley S. Murr, Gary R. Klinefelter, Lillian F. Strader

Publikováno v: Environmental Health Perspectives

Background Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. Objective We aimed to evaluate a drinking water mixture of the four regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb56d9c8c6f123be36295d030a7a375
http://europepmc.org/articles/PMC4455591

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Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

Autor: Carmen R. Wood, Crystal L. Johnson, J. Christopher Corton, Michael H. George, Charles E. Wood, Gleta Carswell, Micheal P. Jokinen, Greg R. Olson, Brian N. Chorley, Anthony B. DeAngelo, Julia H. Carter, Virunya S. Bhat, Susan D. Hester

Publikováno v: Toxicological Sciences. 139:21-34

More efficient models are needed to assess potential carcinogenicity hazard of environmental chemicals based on early events in tumorigenesis. Here, we investigated time course profiles for key events in an established cancer mode of action. Using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db416e7f722af3b073ca7cd102d90322
https://doi.org/10.1093/toxsci/kfu025

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Characterization of Peroxisome Proliferator–Activated Receptor α—Independent Effects of PPARα Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate also Activates the Constitutive-Activated Receptor

Autor: Carmen R. Wood, J. Christopher Corton, Michael H. George, Beena Vallanat, Lauren M. Aleksunes, Curtis D. Klaassen, Hongzu Ren

Publikováno v: Toxicological Sciences. 113:45-59

Peroxisome proliferator chemicals (PPC) are thought to mediate their effects in rodents on hepatocyte growth and liver cancer through the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha. Recent studies indicate that the plast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d1eed735d3677763ee2ccb055f3401
https://doi.org/10.1093/toxsci/kfp251

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Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic B6C3F1 mouse lung result from stable DNA adducts

Autor: Michael H. George, Jeffrey A. Ross, Tanya Moore, Sharon A. Leavitt

Publikováno v: Mutagenesis. 23:445-450

Dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P) are carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are each capable of forming a variety of covalent adducts with DNA. Some of the DNA adducts formed by these PAHs have been demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae1d9015429d479d88f5d1a5e914a8c
https://doi.org/10.1093/mutage/gen033

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Toxicity Profiles in Rats Treated with Tumorigenic and Nontumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil

Autor: Tanya Moore, Sheau-Fung Thai, Michael H. George, Gail M. Nelson, Carlton P. Jones, Julie R. Thibodeaux, Susan D. Hester, Guobin Sun, Ernest Winkfield, James W. Allen, Sharon Leavitt, Douglas C. Wolf, Stephen Nesnow, Barbara C. Roop, Don A. Delker

Publikováno v: Toxicologic Pathology. 34:895-902

Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00155d05c53153f96380bf60d8cfeab
https://doi.org/10.1080/01926230601047808

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Molecular biomarkers of oxidative stress associated with bromate carcinogenicity

Autor: Tanya Moore, Michael H. George, David R. Geter, William O. Ward, James W. Allen, Bobby Crissman, Adam Swank, Gail M. Nelson, Anthony B. DeAngelo, Don A. Delker, Stephen Kilburn, Barbara C. Roop, Gary E. Hatch, Ralph Slade

Publikováno v: Toxicology. 221:158-165

Biomarkers of exposure & effect:: validationBiomarker: oxidative stress (gene expression)Exposure/effect represented: potassium bromate (KBrO3)/ DNA damageStudy type (in vitro, animals, humans): male F344 ratsMode of exposure (if in vivo) (acute, chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c3cdf58cacf9156e0ee5a53a12f62d
https://doi.org/10.1016/j.tox.2005.12.011

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Vehicle and Mode of Administration Effects on the Induction of Aberrant Crypt Foci in the Colons of Male F344/N Rats Exposed to Bromodichloromethane

Autor: Michael H. George, Gloria Huggins-Clark, Steve Kilburn, Anthony B. DeAngelo, Tanya Moore, David R. Geter

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 67:23-29

Bromodichloromethane (BDCM) and tribromomethane given by corn oil gavage were previously found to induce neoplasia in the large intestine of rats. Our chronic bioassay of BDCM administered in drinking water failed to produce colon neoplasia in male F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b97836fd57606b6fe5c2e59d8b6ab
https://doi.org/10.1080/15287390490253642

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Altered gene expression in mouse livers after dichloroacetic acid exposure

Autor: Sheau-Fung Thai, James C. Fuscoe, Michael H. George, James W. Allen, Anthony B. DeAngelo

Publikováno v: Mutation Research/Reviews in Mutation Research. 543:167-180

Dichloroacetic acid (DCA) is a major by-product of water disinfection by chlorination. Several studies have demonstrated that DCA exhibits hepatocarcinogenic effects in rodents when administered in drinking water. This chemical does not appear to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b56efd46b6960dd47cd7a4ebc52e4bc
https://doi.org/10.1016/s1383-5742(03)00014-0

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