Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Michael H. B. Stowell"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-5 (2022)
The current state and limitations of research on extracellular vesicles in central nervous system (CNS) signaling are discussed, with particular focus on EV-mediated cargo transfer.
Externí odkaz:
https://doaj.org/article/6c8ced3ee02f439f94b4ee21dfb7e890
Autor:
Junhee Park, Jie Li, John P. Mayer, Kerri A. Ball, Jiayi Wu, Catherine Hall, Domenico Accili, Michael H. B. Stowell, Xiao-chen Bai, Eunhee Choi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Genetic mutations of insulin receptor (IR) cause severe insulin resistance syndromes with no current treatment or cure. Here, the authors present that insulin-independent IR activation mechanism by peptide agonist which activate non-functional IR mut
Externí odkaz:
https://doaj.org/article/3c42c5abf8ed4d0ca0fe281573c41d63
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
As the resolution revolution in CryoEM expands to encompass all manner of macromolecular complexes, an important new frontier is the implementation of cryogenic time resolved EM (cryoTREM). Biological macromolecular complexes are dynamic systems that
Externí odkaz:
https://doaj.org/article/77420cf0a25c45588bee127d55b8db47
Autor:
Dustin N. White, Michael H. B. Stowell
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication. Aberrant molecular responses to calcium signalin
Externí odkaz:
https://doaj.org/article/8b32ea5ee30b49f6a8990c7010194d3e
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 299 (2019)
The distribution of amyloid beta peptide 42 (Aβ42) between model exosomal membranes and a buffer solution was measured. The model membranes contained liquid-ordered regions or phosphatidylserine. Results demonstrated that up to ca. 20% of amyloid pe
Externí odkaz:
https://doaj.org/article/f43131c724ff451eb30572851290b58c
Autor:
Jie Li, Junhee Park, John P. Mayer, Kristofor J. Webb, Emiko Uchikawa, Jiayi Wu, Shun Liu, Xuewu Zhang, Michael H. B. Stowell, Eunhee Choi, Xiao-chen Bai
Publikováno v:
Nat Struct Mol Biol
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of each binding event during IR activation remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e71d00cbcd322f8f4859179900dbcf
https://doi.org/10.1038/s41594-022-00750-6
https://doi.org/10.1038/s41594-022-00750-6
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182804 (2017)
Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemi
Externí odkaz:
https://doaj.org/article/969df48db4b54b45a1ff335a847df2be
Autor:
Md. Mahfuzur Rahman, Tamara Basta, Jinfeng Teng, Myeongseon Lee, Brady T. Worrell, Michael H. B. Stowell, Ryan E. Hibbs
Publikováno v:
Nat Struct Mol Biol
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to understand at the level of three-dimensional structure how agonists and antagonists alter n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fd6e1ee643ea6964fc9bb9d0399ee0
https://europepmc.org/articles/PMC9531584/
https://europepmc.org/articles/PMC9531584/
Autor:
Tamara, Basta, Garry P, Morgan, Eileen T, O'Toole, Nalini R, Rao, Jeffrey N, Savas, Michael H B, Stowell
Publikováno v:
Membrane Trafficking ISBN: 9781071622087
Methods Mol Biol
Methods Mol Biol
Electron tomography of the chemical synapse provides important architectural information regarding the organization of synaptic organelles including synaptic vesicles, Nissl bodies, and early endosomes. Here, we describe methods for the preparation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea48ee4d7df87d45af3f1ed7854ef37
https://doi.org/10.1007/978-1-0716-2209-4_10
https://doi.org/10.1007/978-1-0716-2209-4_10