Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Michael Grundman"'
Autor:
Alexandria Wise-Brown, Sharon A. Brangman, J. Neil Henderson, Monica Willis-Parker, Stephanie Monroe, Jacobo E. Mintzer, Michael Grundman, Janice Smith, Rachelle S. Doody, Helen Lin, Beverly Assman, Gregory A. Rippon, Rozanno Gonzales, Sheila Seleri Assunção
Publikováno v:
EClinicalMedicine, Vol 73, Iss , Pp 102693- (2024)
Summary: Clinical trial participation across disease areas, including Alzheimer's disease (AD), has been biased towards White participants of European ancestry. To support clinical decision-making across diverse populations, we must recognize and add
Externí odkaz:
https://doaj.org/article/aec656aa93cf43dfb4d012014893d18b
Autor:
Christopher H. van Dyck, Adam P. Mecca, Ryan S. O’Dell, Hugh H. Bartlett, Nina G. Diepenbrock, Yiyun Huang, Mary E. Hamby, Michael Grundman, Susan M. Catalano, Anthony O. Caggiano, Richard E. Carson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ oligomers are among
Externí odkaz:
https://doaj.org/article/f8737e4097cf48b39181feb795adf981
Autor:
Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Trial registration ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153
Externí odkaz:
https://doaj.org/article/e8a0ebe6290e4359b7e72393eaf523ef
Autor:
Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky, Harry LeVine, Michael Grundman, Anthony O. Caggiano, John R. Cirrito, Susan M. Catalano, Mary E. Hamby
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/19f084bea18e49d6b821e4355697a8ba
Autor:
Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, Mary E. Hamby
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6251 (2023)
There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related degenerative diseases of the central nervous system. The sigma-2 receptor (S2R), encoded by TMEM97, is expressed in brain and retinal
Externí odkaz:
https://doaj.org/article/927a617bc92e4eb59b28c8ff00358f8d
Autor:
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano, the Synaptic Health Endpoints Working Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approach
Externí odkaz:
https://doaj.org/article/1df4eea74a444af7b16f1b08d1784dd1
EMPOWER AD: A Novel, Patient-Centric, Longitudinal, Clinical Dataset in the United States (P4-6.006)
Autor:
Michael Grundman, Elizabeth S. Mearns, Karina Raimundo, Chris Wallick, Katherine Belendiuk, Katherine Glockner, Seth Colbert-Pollack, Jiayin Xue, Hinal Patel, Sheila Seleri
Publikováno v:
Monday, April 24.
Autor:
Sheila Seleri, Sharon Brangman, J. Neil Henderson, Monica Parker, Stephanie Monroe, Jacobo Mintzer, Alexandria Wise-Brown, Michael Grundman, Janice Smith, Rachelle Doody, Helen Lin, Beverly Assman, Gregory Rippon
Publikováno v:
Tuesday, April 25.
Autor:
Keva Gwin, Martin Ladouceur, Howard Fillit, Marjolaine Gauthier-Loiselle, Ruth A Duffy, Ann Hartry, Michael Grundman, Ross A. Baker, Myrlene Sanon Aigbogun, Annie Guerin, Martin Cloutier
Publikováno v:
Journal of Alzheimer's Disease
Background: Few studies have examined patient characteristics and treatment patterns among patients with dementia and agitation in the United States (US). Objective: To examine real-world treatment patterns and characteristics of patients with agitat
Autor:
Howard Fillit, Meriel Owen, Elizabeth Finger, Yuko Hara, Susan Dickinson, Nicholas McKeehan, Samuel P. Dickson, Lon S. Schneider, Howard Feldman, Michael Grundman, Judith Jaeger, Melanie Quintana, Jian Zhu, Jeffrey L. Cummings, Deli Wang, Debra Niehoff, J. Michael Ryan, Alessio Travaglia, Richard C. Mohs, Dawn C. Matthews, Jessica T. Markowitz, Lauren G. Friedman, Suzanne Hendrix
Publikováno v:
Neurology, vol 96, iss 20
Neurology
article-version (Version of Record) 3
Neurology
article-version (Version of Record) 3
Drug development for Alzheimer disease and other neurodegenerative dementias, including frontotemporal dementia, has experienced a long history of phase 2 and phase 3 clinical trials that failed to show efficacy of investigational drugs. Despite diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482189aa8b99725a2bae96520a4c778
https://escholarship.org/uc/item/7cg5f1h9
https://escholarship.org/uc/item/7cg5f1h9