Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Michael Granato"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0300529 (2024)
Behavioral thresholds define the lowest stimulus intensities sufficient to elicit a behavioral response. Establishment of baseline behavioral thresholds during development is critical for proper responses throughout the animal's life. Despite the rel
Externí odkaz:
https://doaj.org/article/03255a46ed98430f9090751c6b617651
Publikováno v:
eLife, Vol 12 (2023)
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms, we took advantage of
Externí odkaz:
https://doaj.org/article/ad0bd707621b44f78c798b620f0f586f
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002223 (2023)
A critical step for functional recovery from peripheral nerve injury is for regenerating axons to connect with their pre-injury targets. Reestablishing pre-injury target specificity is particularly challenging for limb-innervating axons as they encou
Externí odkaz:
https://doaj.org/article/3f373bdeb3084e77aef7a7c67ebbeee5
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010650 (2023)
Habituation is a foundational learning process critical for animals to adapt their behavior to changes in their sensory environment. Although habituation is considered a simple form of learning, the identification of a multitude of molecular pathways
Externí odkaz:
https://doaj.org/article/327a7e403fc844d0a868250ae5d6fa68
Autor:
Hannah Shoenhard, Michael Granato
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281609 (2023)
Behavioral screens in model organisms have greatly facilitated the identification of genes and genetic pathways that regulate defined behaviors. Identifying the neural circuitry via which specific genes function to modify behavior remains a significa
Externí odkaz:
https://doaj.org/article/075b4bd9860549d9955484d3d48941e6
Autor:
Nicholas J Santistevan, Jessica C Nelson, Elelbin A Ortiz, Andrew H Miller, Dima Kenj Halabi, Zoë A Sippl, Michael Granato, Yevgenya Grinblat
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270903 (2022)
BackgroundThe ability to filter sensory information into relevant versus irrelevant stimuli is a fundamental, conserved property of the central nervous system and is accomplished in part through habituation learning. Synaptic plasticity that underlie
Externí odkaz:
https://doaj.org/article/05f8398aaf7949c8b8514d58c4b3b85a
Autor:
Joy H Meserve, Jessica C Nelson, Kurt C Marsden, Jerry Hsu, Fabio A Echeverry, Roshan A Jain, Marc A Wolman, Alberto E Pereda, Michael Granato
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1008943 (2021)
The acoustic startle response is an evolutionarily conserved avoidance behavior. Disruptions in startle behavior, particularly startle magnitude, are a hallmark of several human neurological disorders. While the neural circuitry underlying startle be
Externí odkaz:
https://doaj.org/article/66523a4c7fc74299ad1b74824cdd69a7
Autor:
Philip D. Campbell, Michael Granato
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 4 (2020)
Schizophrenia remains one of the most debilitating human neurodevelopmental disorders, with few effective treatments and striking consequences felt by individuals, communities and society as a whole. As such, there remains a critical need for further
Externí odkaz:
https://doaj.org/article/8cf0fcad762b43f29f75225bcf40c0d7
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein other
Externí odkaz:
https://doaj.org/article/64b3962177964d1280be358fae515cc7
Autor:
Kurt C. Marsden, Roshan A. Jain, Marc A. Wolman, Fabio A. Echeverry, Jessica C. Nelson, Katharina E. Hayer, Ben Miltenberg, Alberto E. Pereda, Michael Granato
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 878-887 (2018)
Summary: Sensory experiences dynamically modify whether animals respond to a given stimulus, but it is unclear how innate behavioral thresholds are established. Here, we identify molecular and circuit-level mechanisms underlying the innate threshold
Externí odkaz:
https://doaj.org/article/7d0edbe892724be2ad54fcfffc731fc2