Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael Getman"'
Autor:
Sierra Fox, Jacquelyn A. Myers, Christina Davidson, Michael Getman, Paul D. Kingsley, Nicholas Frankiewicz, Michael Bulger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information
Externí odkaz:
https://doaj.org/article/ee98d3c56057456481faaea3dd0b0a5f
Autor:
Jacquelyn A. Myers, Tyler Couch, Zachary Murphy, Jeffrey Malik, Michael Getman, Laurie A. Steiner
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Background SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishment of higher order chr
Externí odkaz:
https://doaj.org/article/21e5f727a96545f08e136f0f08e40780
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2376-2383 (2017)
Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process. Setd8 is the sole enzyme that can mon
Externí odkaz:
https://doaj.org/article/8366e27eb64b4227b23ca6021af35aab
Autor:
Bing Guo, Scott C. Friedland, William Alexander, Jacquelyn A. Myers, Wenjia Wang, Michael R. O’Dell, Michael Getman, Christa L. Whitney-Miller, Diana Agostini-Vulaj, Aaron R. Huber, Stephano S. Mello, Paula M. Vertino, Hartmut K. Land, Laurie A. Steiner, Aram F. Hezel
Publikováno v:
Cell reports. 40(9)
Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using muri
Autor:
Jayme L. Olsen, Kathleen E. McGrath, Kristin Murphy, Taylor Schofield, Michael Getman, Mohandas Narla, Lionel Blanc, Vincent P Schulz, Patrick G. Gallagher, Laurie A. Steiner, James Palis
Publikováno v:
Blood. 140:8152-8152
Publikováno v:
Blood. 140:704-704
Autor:
Jacquelyn Myers, Laurie A. Steiner, Vincent P. Schulz, Tyler A Couch, Narla Mohandas, Zachary C. Murphy, Michael Getman, Cal D. Palumbo, Hongxia Yan, Kristin Murphy, Kimberly Lezon-Geyda, Patrick G. Gallagher
Publikováno v:
Blood
The terminal maturation of human erythroblasts requires significant changes in gene expression in the context of dramatic nuclear condensation. Defects in this process are associated with inherited anemias and myelodysplastic syndromes. The progressi
Autor:
Tyler A Couch, Jeffrey Malik, Michael Getman, Jacquelyn A. Myers, Zachary C. Murphy, Laurie A. Steiner
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Background SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishment of higher order chromatin st
Publikováno v:
Blood. 138:284-284
Terminal erythroid maturation is associated with dramatic changes in gene expression in the setting of a cell that is undergoing rapid division and nuclear condensation. Disruption of this process is associated with inherited anemias and myelodysplas
Publikováno v:
Blood. 138:286-286
Erythropoiesis requires dramatic changes in gene expression in a cell that is rapidly proliferating and undergoing progressive nuclear condensation in anticipation of enucleation. Disruption of this process is associated with myelodysplastic syndrome