Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael Gersemann"'
Autor:
Sabine Nuding, Michael Gersemann, Yoshio Hosaka, Sabrina Konietzny, Christian Schaefer, Julia Beisner, Bjoern O Schroeder, Maureen J Ostaff, Katunori Saigenji, German Ott, Martin Schaller, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73867 (2013)
BACKGROUND:Although antimicrobial peptides protect mucus and mucosa from bacteria, Helicobacter pylori is able to colonize the gastric mucus. To clarify in which extend Helicobacter escapes the antimicrobial defense, we systematically assessed suscep
Externí odkaz:
https://doaj.org/article/5854f3c9affe4c03b8c15a05497074b9
Autor:
Svetlana Becker, Tobias A. Oelschlaeger, Andy Wullaert, Katerina Vlantis, Manolis Pasparakis, Jan Wehkamp, Eduard F. Stange, Michael Gersemann
Publikováno v:
PLoS ONE, Vol 8, Iss 5 (2013)
Externí odkaz:
https://doaj.org/article/eeefa290a0814dfe92024667df3cc158
Autor:
Svetlana Becker, Tobias A Oelschlaeger, Andy Wullaert, Katerina Vlantis, Manolis Pasparakis, Jan Wehkamp, Eduard F Stange, Michael Gersemann
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55620 (2013)
The human colon harbours a plethora of bacteria known to broadly impact on mucosal metabolism and function and thought to be involved in inflammatory bowel disease pathogenesis and colon cancer development. In this report, we investigated the effect
Externí odkaz:
https://doaj.org/article/84b721f9bcfc479baed40b949378bb28
Autor:
Maureen J Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Irmgard Kübler, Michael Gersemann, Rachel Cooney, Derek Jewell, Walter Reinisch, Séverine Vermeire, Paul Rutgeerts, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://doaj.org/article/56702dae105843a4a2280f10511cdf3f
Autor:
L Courth, S N Fehr, Jan Wehkamp, Bjoern O. Schroeder, U Meyer-Hoffert, Eduard F. Stange, Michael Gersemann, S U Jaeger
Publikováno v:
Mucosal Immunology
Human β-defensin 1 (hBD-1) is an antimicrobial peptide expressed by epithelia and hematopoietic cells. We demonstrated recently that hBD-1 shows activity against enteric commensals and Candida species only after its disulfide bonds have been reduced
Autor:
Lena Antoni, Peter Fritz, Michael Gersemann, Sabine Nuding, Naohide Oue, Wataru Yasui, Svetlana Becker, Eduard F. Stange, German Ott, Jan Wehkamp
Publikováno v:
Journal of Crohn's and Colitis. 6:425-434
Background: Olfactomedin-4 (OLFM4) is a glycoprotein characteristic of intestinal stem cells and apparently involved in mucosal defense of the stomach and colon. Here we studied its expression, regulation and function in IBD. Methods: The expression
Autor:
Frank J. T. Staal, Machteld M. Tiemessen, Gøri Perminow, Matthias Schwab, Guoxing Wang, Maureen Jeanette Ostaff, Julia Beisner, Jan Wehkamp, Morten H. Vatn, Zora Teltschik, Eduard F. Stange, Michael Gersemann
Publikováno v:
AJP-Gastrointestinal and Liver Physiology, 307(5), G487-G498
Wnt signaling regulates small intestinal stem cell maintenance and Paneth cell differentiation. In patients with ileal Crohn's disease (CD), a decrease of Paneth cell α-defensins has been observed that is partially caused by impaired TCF-4 and LRP6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99d332ef4e459c8076530aac78b4445
https://hdl.handle.net/1887/104530
https://hdl.handle.net/1887/104530
Autor:
Eduard F. Stange, Tobias A. Oelschlaeger, Katerina Vlantis, Svetlana Becker, Andy Wullaert, Jan Wehkamp, Michael Gersemann, Manolis Pasparakis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5 (2013)
PLoS ONE, Vol 8, Iss 5 (2013)
Autor:
German Ott, Eduard F. Stange, Lena Antoni, Michael Gersemann, Dagmar Weller, Jan Wehkamp, Sabine Nuding
Publikováno v:
Journal of Crohn'scolitis. 7(12)
Background and aims To prevent bacterial adherence and translocation, the colonic mucosa is covered by a protecting mucus layer and the epithelium synthesizes antimicrobial peptides. The present qualitative study investigated the contents and interac
Autor:
N Oue, Y Wataru, Sabine Nuding, Svetlana Becker, Jan Wehkamp, Michael Gersemann, L Antoni, Eduard F. Stange
Publikováno v:
Zeitschrift für Gastroenterologie. 49