Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael G. Spelios"'
Autor:
John A. Olsen, Lauren A. Kenna, Regine C. Tipon, Michael G. Spelios, Mark M. Stecker, Eitan M. Akirav
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 227-235 (2016)
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Minimally invasive biomarkers of MS are required for disease diagnosis and treatment. Differentially methylated circulating-free DNA (cfDNA) is a useful bioma
Externí odkaz:
https://doaj.org/article/2f52b81ca96c44a088633b9229625d60
Publikováno v:
Immunology Letters
SARS-CoV-2 harbors a unique S1/S2 furin cleavage site within its spike protein, which can be cleaved by furin and other proprotein convertases. Proteolytic activation of SARS-CoV-2 spike protein at the S1/S2 boundary facilitates interaction with host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64371777517973c25d3120e901ee5cd0
https://pubmed.ncbi.nlm.nih.gov/35007661
https://pubmed.ncbi.nlm.nih.gov/35007661
Autor:
Richard A. Friedman, Ann Marie Schmidt, Ravichandran Ramasamy, Michaele B. Manigrasso, Alexander Shekhtman, Michael G Spelios, Robert J. DeVita
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525aeccafd31fedc124f4f23ac58b420
https://doi.org/10.1096/fasebj.2019.33.1_supplement.574.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.574.3
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 314(5)
Three-dimensional (3D) pseudoislets (PIs) can be used for the study of insulin-producing β-cells in free-floating islet-like structures similar to that of primary islets. Previously, we demonstrated the ability of islet-derived endothelial cells (iE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d5245311a160552c5ee834a94a72fc
https://pubmed.ncbi.nlm.nih.gov/29351476
https://pubmed.ncbi.nlm.nih.gov/29351476
Publikováno v:
Journal of Biological Chemistry. 290:15250-15259
The co-culturing of insulinoma and islet-derived endothelial cell (iEC) lines results in the spontaneous formation of free-floating pseudoislets (PIs). We previously showed that iEC-induced PIs display improved insulin expression and secretion in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7eb1514cb30cc07e22ae3155716556
https://doi.org/10.1074/jbc.m114.628784
https://doi.org/10.1074/jbc.m114.628784
Publikováno v:
Diabetology & Metabolic Syndrome
Background Gestational diabetes mellitus (GDM) affects approximately 7–17 % of all pregnancies and has been recognized as a significant risk factor to neonatal and maternal health. Postpartum, GDM significantly increases the likelihood of developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d550182a2775c6f32fe89e5c5af5b86a
https://doi.org/10.1186/s13098-016-0175-z
https://doi.org/10.1186/s13098-016-0175-z
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D. Amylin is highly expressed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928ee94030b3570493e7b889ab02791f
http://europepmc.org/articles/PMC4844136
http://europepmc.org/articles/PMC4844136
Autor:
Michael G. Spelios, Michalakis Savva
Publikováno v:
FEBS Journal. 275:148-162
Novel N,N′-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids were synthesized and their physicochemical properties in lamellar assemblies with and without plasmid DNA were evaluated to elucidate the structural requirements of these doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7474cf5fd168ae9045ce772048805e6
https://doi.org/10.1111/j.1742-4658.2007.06185.x
https://doi.org/10.1111/j.1742-4658.2007.06185.x
Publikováno v:
Biochemistry. 49(27)
The cationic lipid 1,3-dimyristoylamidopropane-2-[bis(2-dimethylaminoethane)] carbamate (1,3lb2) was applied as a delivery system for small interfering RNA (siRNA) to inhibit the production of vascular endothelial growth factor (VEGF) in vitro in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507c9752ac00748e8fa41fa1dcd32e8b
https://pubmed.ncbi.nlm.nih.gov/20515078
https://pubmed.ncbi.nlm.nih.gov/20515078
Publikováno v:
Biophysical chemistry. 129(2-3)
The transfection activity and physicochemical properties of the dimyristoyl derivatives from three novel series of double-chained tertiary cationic lipids were compared. Two of the derivatives were constructed as isomers with different linkages of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00c06ead6436ff2681f878b5906873b
https://pubmed.ncbi.nlm.nih.gov/17573180
https://pubmed.ncbi.nlm.nih.gov/17573180