Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Michael G. Poulos"'
Autor:
Pradeep Ramalingam, Michael C. Gutkin, Michael G. Poulos, Taylor Tillery, Chelsea Doughty, Agatha Winiarski, Ana G. Freire, Shahin Rafii, David Redmond, Jason M. Butler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fi
Externí odkaz:
https://doaj.org/article/bfeb0e9c16e84018b805b3d540fe3b9c
Autor:
Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr
Externí odkaz:
https://doaj.org/article/6b54770221c34086b376c539aef6277a
Autor:
Brandon K. Hadland, Barbara Varnum-Finney, Pankaj K. Mandal, Derrick J. Rossi, Michael G. Poulos, Jason M. Butler, Shahin Rafii, Mervin C. Yoder, Momoko Yoshimoto, Irwin D. Bernstein
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1563-1572 (2017)
Recent evidence points to the embryonic emergence of some tissue-resident innate immune cells, such as B-1a lymphocytes, prior to and independently of hematopoietic stem cells (HSCs). However, whether the full hematopoietic repertoire of embryonic HS
Externí odkaz:
https://doaj.org/article/cccd9b3d8e5145308744a16958428633
Autor:
Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoieti
Externí odkaz:
https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
Autor:
Michael G. Poulos, Michael J.P. Crowley, Michael C. Gutkin, Pradeep Ramalingam, William Schachterle, Jean-Leon Thomas, Olivier Elemento, Jason M. Butler
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 881-894 (2015)
Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM), which govern the delicate balance between HSC quiescence, self-renewal, and differentiation. Previous reports have proposed that HSCs localize to th
Externí odkaz:
https://doaj.org/article/06c03862ec6a47019427c26a553e3d6c
Autor:
Michael G. Poulos, Peipei Guo, Natalie M. Kofler, Sandra Pinho, Michael C. Gutkin, Anastasia Tikhonova, Iannis Aifantis, Paul S. Frenette, Jan Kitajewski, Shahin Rafii, Jason M. Butler
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1022-1034 (2013)
The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endoth
Externí odkaz:
https://doaj.org/article/a2de7d96b8d94890af4dc12d7b19d166
Publikováno v:
Current Stem Cell Reports
Purpose of Review Hematopoietic stem cells (HSCs) sit at the top of the hierarchy that meets the daily burden of blood production. HSC maintenance relies on extrinsic cues from the bone marrow (BM) microenvironment to balance stem cell self-renewal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9917303d7cacfc9ad4adf0fce675ebee
https://pubmed.ncbi.nlm.nih.gov/34868826
https://pubmed.ncbi.nlm.nih.gov/34868826
Autor:
Matthew B. Greenblatt, Elisa Lazzari, David Lopez, Ana G. Freire, Christopher C. Kloss, Michael C. Gutkin, Lizabeth Katsnelson, Christopher Y. Park, Michael J. Crowley, Pradeep Ramalingam, Michael G. Poulos, Jason M. Butler
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes including embryonic development, infectious diseases, and myelosuppressive injuries caused b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db2de4b0c27773c99de0a60f7d9dcc8
http://europepmc.org/articles/PMC6997369
http://europepmc.org/articles/PMC6997369
Autor:
Chaitanya R. Badwe, Jason M. Butler, Balvir Kunar, Sina Y. Rabbany, Michael G. Poulos, Shahin Rafii, Koji Shido, Raphael Lis, Peipei Guo, Brisa Palikuqi, Bi-Sen Ding
Publikováno v:
The Journal of Clinical Investigation
Angiocrine factors, such as Notch ligands, supplied by the specialized endothelial cells (ECs) within the bone marrow and splenic vascular niche play an essential role in modulating the physiology of adult hematopoietic stem and progenitor cells (HSP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d6545ba0ad010d2b9556b6d59fcdf5
https://doi.org/10.1172/jci92309
https://doi.org/10.1172/jci92309
Autor:
Pradeep Ramalingam, Pierre Llanos, Katherine Gilleran, Jason M. Butler, Michael G. Poulos, Sina Y. Rabbany, Michael C. Gutkin
Publikováno v:
Journal of Clinical Investigation. 127:4163-4178
Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the aged microenvironment has not been adequately evaluated. Understanding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb6f43765f3ecc706a74303eb9fc49a
https://doi.org/10.1172/jci93940
https://doi.org/10.1172/jci93940