A biomimetic receptor for glucose

Autor: Anthony P. Davis, Michael G. Orchard, Hongyu Li, Laurent Chabanne, Johnathan V. Matlock, Robert A. Tromans, Thomas Carter, Matthew P. Crump

Publikováno v: Tromans, R A, Carter, T S, Chabanne, L, Crump, M P, Li, H, Matlock, J V, Orchard, M G & Davis, A P 2019, ' A biomimetic receptor for glucose ', Nature Chemistry, vol. 11, no. 1, pp. 52-56 . https://doi.org/10.1038/s41557-018-0155-z

Specific molecular recognition is routine for biology, but has proved difficult to achieve in synthetic systems. Carbohydrate substrates are especially challenging, because of their diversity and similarity to water, the biological solvent. Here we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa08885a663d9c8f5865a5678b50dd04
https://pubmed.ncbi.nlm.nih.gov/30420776

ChemInform Abstract: Synthesis of Cyclo-bis(7α,12α-diacetoxy-3β- dicyanomethyl-3α-(4-methylenephenyl)cholanamide); a Cholaphane with Reduced Flexibility and Externally-Directed Functionality

Autor: Michael G. Orchard, Anthony P. Davis

Publikováno v: ChemInform. 24

A second ‘cholaphane’ framework is manifested in the title compound 8, which has been prepared from methyl 3α,7α, 12α-triacetoxycholanoate 9 in 23% overall yield. The synthesis involves the Knoevenagel condensation of ketone 11 with malononitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c06c772d7c7b7d6e9c829a358350972e
https://doi.org/10.1002/chin.199334248

ChemInform Abstract: The Stereoselective Addition of Organometallic Reagents to Electron- Deficient Alkylidenecyclohexanes: Alternative Linkages for Cholaphane Synthesis

Autor: Anthony P. Davis, Thomas J. Egan, Michael G. Orchard, Patrick McArdle, Desmond Cunningham

Publikováno v: ChemInform. 24

Knoevenagel condensations between t-butylcyclohexanone and malononitrile, Meldrum's acid and ethyl cyanoacetate gave electron-deficient alkenes which underwent equatorial-selective attack by chemoselective aryl organometallic reagents. Further transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b55a09b8fd0bbdf2493655155b83ba25
https://doi.org/10.1002/chin.199306120

Rhodanine-3-acetic Acid Derivatives as Inhibitors of Fungal Protein Mannosyl Transferase 1 (PMT1)

Autor: Michael G. Orchard, et al. et al.

Publikováno v: ChemInform. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bad67093ecdfa2cc4f41ff6152ac45e
https://doi.org/10.1002/chin.200445146

Stereocontrolled synthesis of cholic acid derivatives with N-protected 7β- and/or 12β-amino substituents

Autor: Anthony P. Davis, Michael G. Orchard

Publikováno v: Tetrahedron Letters. 33:5111-5112

Methyl cholanoates with protected amino groups in either or both of the 7β- and 12β-positions have been synthesized from cholic acid 1 via sulphonylation, azide displacement and reduction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f56e11f70a84502af990610d5f459c5f
https://doi.org/10.1016/s0040-4039(00)61204-2