Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Autor: Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier

Publikováno v: Cellular Oncology, Vol 31, Iss 5, Pp 345-356 (2009)

Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action dep

Externí odkaz: https://doaj.org/article/66aef155731f44db8bae098c9be18872

CFTR is a tumor suppressor gene in murine and human intestinal cancer

Autor: Gerrit A. Meijer, Remond J.A. Fijneman, B L N Than, David A. Largaespada, Robert T. Cormier, A Niemczyk, A Schumann, Janneke F. Linnekamp, Louis Vermeulen, A Rod, Craig A. Hodges, Juan E. Abrahante, Ying Zhang, V Bruner, Michael G. O’Sullivan, Timothy K. Starr, Jan Paul Medema, T Luczak, E Van den Broek, Patricia M. Scott

Publikováno v: Oncogene, 36(24). Nature Publishing Group
Oncogene, 35(32), 4191-4199. Nature Publishing Group
Oncogene, 35(32), 4179-4187. Nature Publishing Group
Than, B L N, Linnekamp, J F, Starr, T K, Largaespada, D A, Rod, A, Zhang, Y, Bruner, V, Abrahante, J, Schumann, A, Luczak, T, Niemczyk, A, O'Sullivan, M G, Medema, J P, Fijneman, R J A, Meijer, G A, Van den Broek, E, Hodges, C A, Scott, P M, Vermeulen, L & Cormier, R T 2016, ' CFTR is a tumor suppressor gene in murine and human intestinal cancer ', Oncogene, vol. 35, no. 32, pp. 4191-4199 . https://doi.org/10.1038/onc.2015.483

CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9d320f158e53f3679bf69c6de613aa
https://doi.org/10.1038/onc.2015.483

Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats

Autor: Ahmad Ali Shaik, Chengguo Xing, Daniel D. Gallaher, Michael G. O’Sullivan, Julie Triolet

Publikováno v: Nutrition and Cancer. 64:838-846

Epidemiological studies suggest that kava reduces colon cancer risk. However, no experimental studies of the chemopreventive properties of kava toward colon cancer have been reported. Further, there are concerns regarding hepatotoxicity of kava. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691f1367c400f07fd49f1f744f812013
https://doi.org/10.1080/01635581.2012.689917

Epithelioid hemangioendothelioma of the spine

Autor: Charles Marks, Mahmoud Hamdy Kamel, Chris Lim, Catherine Keohane, Michael G. O'sullivan, Kristian Aquilina

Publikováno v: Journal of Neurosurgery: Spine. 3:393-399

✓ Epithelioid hemangioendothelioma (EH) is a rare tumor of vascular origin. The authors describe two cases of spinal EH, one involving the T-10 vertebra and the second involving the upper cervical spine. In the first case the patient underwent rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb44dfd23a54ddcc024d26116dd69207
https://doi.org/10.3171/spi.2005.3.5.0393

The Surgical Resectability of Meningiomas of the Cavernous Sinus

Autor: Michael G. O'Sullivan, Harry R. van Loveren, John M. Tew

Publikováno v: Neurosurgery. 40:238-247

OBJECTIVE:The optimal management for patients with cavernous sinus meningiomas remains controversial. We attempt to contribute to the ongoing debate of appropriate surgical indications.METHODS:In this retrospective review, 39 patients, including 27 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::deea6117705a5a056b8d9dd4db04ae89
https://doi.org/10.1097/00006123-199702000-00003