Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Michael G. O'Rand"'
Autor:
Antoniel A. S. Gomes, Natália C. M. Santos, Leonardo R. Rosa, Rafael J. Borges, Marcos R. M. Fontes, Katherine G. Hamil, Michael G. O’Rand, Erick J. R. Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Novel male contraceptives will promote gender equality in sharing contraceptive responsibility. The sperm-associated protein epididymal protease inhibitor (EPPIN) is a promising target for non-hormonal male contraception. EPPIN interacts wit
Externí odkaz:
https://doaj.org/article/823afa632081474b9071c261e38fb539
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195953 (2018)
Men have two practical choices for contraception; the condom which has a high typical use failure rate or vasectomy. New male hormonal and non-hormonal contraceptives are under development that target either the production of sperm (spermatogenesis)
Externí odkaz:
https://doaj.org/article/31a98184d00f46589620b824060bea8a
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82014 (2013)
Semenogelin I (SEMG1) is found in human semen coagulum and on the surface of spermatozoa bound to EPPIN. The physiological significance of the SEMG1/EPPIN interaction on the surface of spermatozoa is its capacity to modulate sperm progressive motilit
Externí odkaz:
https://doaj.org/article/375ddfd6a5db47568b1663c9aa9ee2d7
Autor:
Jan Münch, Marielle Cavrois, Kara Marson, Michael G. O'Rand, Nargis Kohgadai, Warner C. Greene, Olena Sakk, Annika Röcker, Christopher D. Pilcher, Shariq M. Usmani, Frank Kirchhoff, Nathallie Sandi-Monroy, Friedrich Gagsteiger, Ludger Ständker, Katherine G. Hamil, Polina V. Lishko, Mauricio Montano, Jared Rosen, Jason Neidleman, James F. Smith, Nadia R. Roan
Publikováno v:
eLife, Vol 6 (2017)
Roan, NR; Sandi-Monroy, N; Kohgadai, N; Usmani, SM; Hamil, KG; Neidleman, J; et al.(2017). Semen amyloids participate in spermatozoa selection and clearance. eLife, 6. doi: 10.7554/eLife.24888. UCSF: Retrieved from: http://www.escholarship.org/uc/item/09v2w1jh
eLife
Roan, NR; Sandi-Monroy, N; Kohgadai, N; Usmani, SM; Hamil, KG; Neidleman, J; et al.(2017). Semen amyloids participate in spermatozoa selection and clearance. eLife, 6. doi: 10.7554/eLife.24888. UCSF: Retrieved from: http://www.escholarship.org/uc/item/09v2w1jh
eLife
Unlike other human biological fluids, semen contains multiple types of amyloid fibrils in the absence of disease. These fibrils enhance HIV infection by promoting viral fusion to cellular targets, but their natural function remained unknown. The simi
Autor:
Polina V. Lishko, Jason Neidleman, James F. Smith, Michael G. O'Rand, Nadia R. Roan, Frank Kirchhoff, Mauricio Montano, Ludger Ständker, Nargis Kohgadai, Shariq M. Usmani, Christopher D. Pilcher, Friedrich Gagsteiger, Annika Röcker, Nathallie Sandi-Monroy, Olena Sakk, Jared Rosen, Jan Münch, Marielle Cavrois, Kara Marson, Katherine G. Hamil, Warner C. Greene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7402defcac8146ec4af643ffa8f97d19
https://doi.org/10.7554/elife.24888.029
https://doi.org/10.7554/elife.24888.029
Autor:
Michael G. O'Rand, Richard T. Richardson, Esther E. Widgren, Erick J. R. Silva, Katherine G. Hamil
Publikováno v:
Journal of Andrology. 32:698-704
The Laboratories for Reproductive Biology at the University of North Carolina at Chapel Hill began collaboration with Human Genome Sciences (Rockville, Maryland) to sequence a human epididymal library and identify epididymal-specific genes. Among the
Publikováno v:
Biology of Reproduction. 80:279-285
Epididymal protease inhibitor (eppin [official symbol, SPINLW1]) is of interest as a male contraceptive target because of its specificity and location on the human sperm surface. We have examined the effect of anti-eppin antibodies from infertile mal
Publikováno v:
Biology of Reproduction. 77:476-484
Eppin (SPINLW1; serine peptidase inhibitor-like with Kunitz and WAP domains 1 (eppin); epididymal protease inhibitor) coats the surface of human ejaculate spermatozoa and originates from Sertoli and epididymal epithelial cells. In this study, we have
Autor:
Michael G. O'Rand, William F. Marzluff, Eric J. Wagner, Gail Grossman, Oleg M. Alekseev, Kelly D. Sullivan, Randy J. Thresher, Esther E. Widgren, Richard T. Richardson
Publikováno v:
Journal of Biological Chemistry. 281:21526-21534
A multichaperone nucleosome-remodeling complex that contains the H1 linker histone chaperone nuclear autoantigenic sperm protein (NASP) has recently been described. Linker histones (H1) are required for the proper completion of normal development, an
Publikováno v:
Gene. 371:52-58
NASP (nuclear autoantigenic sperm protein) is a histone H1 binding protein expressed in all cells undergoing division. We have previously reported the sequence for the mouse NASP gene and analyzed its proximal promoter region in silico to determine p