Výsledky vyhledávání - "Michael G. Nichols"

Ultrasmall Mixed Eu–Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI

Autor: Aria W. Tarudji, Michael G. Nichols, Connor C. Gee, Forrest M. Kievit, Badrul Alam Bony, Hunter A. Miller, Anandakumar Sarella

Publikováno v: ACS Omega
ACS Omega, Vol 5, Iss 26, Pp 16220-16227 (2020)

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have a long-term impact on the quality of life for survivors of all ages. However, there remains no approved treatment that improves outcomes following TBI, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47fd665399e4c06c4ffdac2f9777321
https://doi.org/10.1021/acsomega.0c01890

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Low-intensity light-induced drug release from a dual delivery system comprising of a drug loaded liposome and a photosensitive conjugate

Autor: I. G. Meerovich, Michael G. Nichols, Alekha K. Dash

Publikováno v: Journal of Drug Targeting. 28:655-667

This study reports the development of a binary drug delivery system consisting of charged liposomes and an oppositely charged peptide-photosensitiser conjugate. Liposomes were prepared with phosphatidyl-l-serine as a negatively charged lipid. Calcein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebf343f9fced8b1e74cba9ea84b2046
https://doi.org/10.1080/1061186x.2019.1710838

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Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on squamous cell carcinoma cultures

Autor: Michael G. Nichols, Molly Myers, Dominick Myers, Laura A. Hansen, Dan L. Pham, Christina R. Miller

Publikováno v: Journal of Biomedical Optics

Significance: Deranged metabolism and dysregulated growth factor signaling are closely associated with abnormal levels of proliferation, a recognized hallmark in tumorigenesis. Fluorescence lifetime imaging microscopy (FLIM) of endogenous nicotinamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b004358dddda3aaf84e772a88342488
https://doi.org/10.1117/1.jbo.26.10.106501

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Low-intensity light-induced paclitaxel release from lipid-based nano-delivery systems

Autor: Alekha K. Dash, Michael G. Nichols, I. G. Meerovich

Publikováno v: Journal of Drug Targeting. 27:971-983

Light-induced drug release has been explored as a strategy for externally modulating the release of drug from delivery systems. This study reports the development of a solid lipid nanoparticulate system (SLN) for paclitaxel (PTX), where photosensitiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f61bcbff753aadac6bcca0ef237a5fb
https://doi.org/10.1080/1061186x.2019.1571066

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Akademický článek

Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells.

Autor: Heather C Jensen-Smith, Richard Hallworth, Michael G Nichols

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38471 (2012)

Aminoglycosides (AG), including gentamicin (GM), are the most frequently used antibiotics in the world and are proposed to cause irreversible cochlear damage and hearing loss (HL) in 1/4 of the patients receiving these life-saving drugs. Akin to the

Externí odkaz: https://doaj.org/article/3ec26f0df2924db5bed7b1bd5f13010c

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