Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael G. Lacey"'
Autor:
Michael G Lacey, Gerard Gooding-Williams, Emma J Prokic, Naoki Yamawaki, Stephen D Hall, Ian M Stanford, Gavin L Woodhall
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85109 (2014)
Beta frequency oscillations (10-35 Hz) in motor regions of cerebral cortex play an important role in stabilising and suppressing unwanted movements, and become intensified during the pathological akinesia of Parkinson's Disease. We have used a cortic
Externí odkaz:
https://doaj.org/article/bcdf668e17fa442688b958fdd9cc7a35
Publikováno v:
The Journal of Physiology. 567:977-987
In accordance with its central role in basal ganglia circuitry, changes in the rate of action potential firing and pattern of activity in the globus pallidus (GP)-subthalamic nucleus (STN) network are apparent in movement disorders. In this study we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::502d0ca4bc7ffc02f8bc6cbb5dfeb535
https://doi.org/10.1113/jphysiol.2005.093807
https://doi.org/10.1113/jphysiol.2005.093807
Publikováno v:
Neuroscience. 123:187-200
In Parkinson's disease the neurones of the subthalamic nucleus show increased synchrony and oscillatory burst discharge, thought to reflect a breakdown of parallel processing in basal ganglia circuitry. To understand better the mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419015927f0531d3db9dda1562cc5b98
https://doi.org/10.1016/j.neuroscience.2003.09.008
https://doi.org/10.1016/j.neuroscience.2003.09.008
Autor:
Gerard Gooding-Williams, Ian M. Stanford, Naoki Yamawaki, Emma J. Prokic, Michael G. Lacey, Gavin L. Woodhall, Stephen D. Hall
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85109 (2014)
PLoS ONE
PLoS ONE
Beta frequency oscillations (10–35 Hz) in motor regions of cerebral cortex play an important role in stabilising and suppressing unwanted movements, and become intensified during the pathological akinesia of Parkinson's Disease. We have used a cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5618c1c44b3d35008c58a0dcb71686a8
http://europepmc.org/articles/PMC3896371?pdf=render
http://europepmc.org/articles/PMC3896371?pdf=render
Autor:
Michael G. Lacey, Buckby Le
Publikováno v:
Experimental Brain Research. 141:146-152
Extracellularly recorded field potentials, evoked by stimulation of cortico-nucleus accumbens border, were recorded in the nucleus accumbens (NAcc) in horizontal slices of rat ventral forebrain. The field excitatory postsynaptic potential (EPSP) even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876d0e16393914d61002c0598c855b18
https://doi.org/10.1007/s002210100841
https://doi.org/10.1007/s002210100841
Autor:
Ian M. Stanford, Michael G. Lacey
Publikováno v:
The Journal of Neuroscience. 16:7566-7573
The ability of serotonin to modulate GABA-mediated synaptic input to substantia nigra pars reticulata (SNr) neurons was investigated with the use of whole-cell patch-clamp recording from slices of rat midbrain. Fast evoked GABAAreceptor-mediated syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c2110c31e6b399937304ddc86a8f63
https://doi.org/10.1523/jneurosci.16-23-07566.1996
https://doi.org/10.1523/jneurosci.16-23-07566.1996
Autor:
Michael G. Lacey, C.E. Rick
Publikováno v:
Brain Research. 659:133-137
Extracellular single unit recordings were made from substantia nigra pars reticulata (SNr) neurones in slices of rat brain. Cells fired spontaneous action potentials at 11.4 +/- 0.8 Hz. The GABAA receptor agonist isoguvacine (1-10 microM) reduced fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384dc3bf09903a0aaa63b5253c6aea1b
https://doi.org/10.1016/0006-8993(94)90872-9
https://doi.org/10.1016/0006-8993(94)90872-9
Publikováno v:
Neuroscience. 143(2)
The loss of dopamine in idiopathic or animal models of Parkinson's disease induces synchronized low-frequency oscillatory burst-firing in subthalamic nucleus neurones. We sought to establish whether these firing patterns observed in vivo were preserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d171842caaf27004e06a5873cfc17cc5
https://pubmed.ncbi.nlm.nih.gov/16973296
https://pubmed.ncbi.nlm.nih.gov/16973296
Publikováno v:
Advances in Behavioral Biology ISBN: 0387280650
An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c87afab6201a86adcebf0e72e578a5d
https://publications.aston.ac.uk/id/eprint/38339/1/IBAGS_chapterver5figs.pdf
https://publications.aston.ac.uk/id/eprint/38339/1/IBAGS_chapterver5figs.pdf
Autor:
Michael G. Lacey, Mark A. Wigmore
1A persistent outward K+ current (IPO), activated by depolarization from resting potential, has been identified and characterized in rat subthalamic nucleus (SThN) neurones using whole-cell voltage-clamp recording in brain slices. 2IPO both rapidly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1f05a9607624ca0eab077a7f2f0360
https://europepmc.org/articles/PMC2270091/
https://europepmc.org/articles/PMC2270091/