Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael G. Kiflezghi"'
Autor:
Naci Oz, Elena Vayndorf, Mitsuhiro Tsuchiya, Samantha McLean, Lesly Turcios-Hernandez, Jason N. Pitt, Ben W. Blue, Michael Muir, Michael G. Kiflezghi, Alexander Tyshkovskiy, Alexander Mendenhall, Matt Kaeberlein, Alaattin Kaya
Publikováno v:
GeroScience. 44:1995-2006
At the cellular level, many aspects of aging are conserved across species. This has been demonstrated by numerous studies in simple model organisms like Saccharomyces cerevisiae, Caenorhabdits elegans, and Drosophila melanogaster. Because most geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faeabfc061af5d3ce6682c958ec6a109
https://doi.org/10.1007/s11357-022-00604-5
https://doi.org/10.1007/s11357-022-00604-5
Autor:
Michael G. Kiflezghi, Sunny Nguyen, Mary Ann K. Li, Socheata Thon, Brian M. Wasko, Yordanos C. Elala, Matt Kaeberlein, Daniel E. L. Promislow, Katherine A. Grayden, Thu H. B. Tran, Mitsuhiro Tsuchiya, Yan Ting Zhao, Irika Sinha, Mitchell B. Lee, Deborah Kim, Karl Rodriguez, Ngoc Han Tran, Daniel T. Carr, Jesse Wang, Tu Anh Nguyen, Thao T Tang, Margarete D. Moore, Priya Ragosti, Priya A. Uppal
Publikováno v:
GeroScience
As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad882866b8140dacf583449b1c91f96
https://doi.org/10.1007/s11357-021-00418-x
https://doi.org/10.1007/s11357-021-00418-x
Autor:
Scott R. Kennedy, Alan J. Herr, Thu H. B. Tran, Ian T. Dowsett, Mitchell B. Lee, Niloufar Ghodsian, Anh B. Diep, Michael G. Kiflezghi, Michael S. Chung, Daniel T. Carr, Katherine A. Grayden, Anna Bode, Thao T Tang, Priya A. Uppal, Daniel E. L. Promislow, Ngoc Han Tran, Brian M. Wasko, Sarah G. Stanton, Yordanos C. Elala, Michael Hope, Matt Kaeberlein
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3062-3071
Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Human cancers driven by a mutator phenotype represent an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67dbe15949814a4c0c083d887da464
https://doi.org/10.1073/pnas.1815966116
https://doi.org/10.1073/pnas.1815966116
Autor:
Hyunsung D. Kim, Michael G. Kiflezghi, Ting-I Lee, Ryan M. Kelly, Jared Almazan, Mitchell B. Lee, Siobhan R. Duffy, Shauna A. Hill, Riley Whalen, Feng Y. Yeh, Ellen Huynh, Mitsuhiro Tsuchiya, Bao M.G. Nguyen, Ken Chen, Brian K. Kennedy, Annaiz M. Grimm, Matt Kaeberlein, Joe R. Delaney, Mark A. McCormick, Matthew M. Crane, Ben W. Blue, Jiayi Li, Alison M. Guard, Alexandra Golubeva
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss, Pp 104-108 (2019)
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1477126f5f4ebb210b46df7d14b05
http://www.sciencedirect.com/science/article/pii/S2468501119300380
http://www.sciencedirect.com/science/article/pii/S2468501119300380
Autor:
Mitchell B. Lee, Michael G. Kiflezghi, Mitsuhiro Tsuchiya, Brian Wasko, Daniel T. Carr, Priya A. Uppal, Katherine A. Grayden, Yordanos C. Elala, Tu Anh Nguyen, Jesse Wang, Priya Rastogi, Sunny Nguyen, Yan Ting Zhao, Deborah Kim, Socheata Thon, Irika Sinha, Thao T. Tang, Ngoc H. B. Tran, Thu H. B. Tran, Margarete D. Moore, Mary Ann K. Li, Karl Rodriguez, Daniel E. L. Promislow, Matt Kaeberlein
Publikováno v:
GeroScience. 44:1889-1889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc29c3a20f353d796a47d1e09c3e6da0
https://doi.org/10.1007/s11357-022-00544-0
https://doi.org/10.1007/s11357-022-00544-0
Autor:
Mitchell B. Lee, Matt Kaeberlein, Carine Beaupere, Lauren VanValkenburg, Michael G. Kiflezghi, Daniel E. L. Promislow, Weiwei Dang, Rosalyn B. Chen, Leticia Dinatto, Brian M. Wasko, Vyacheslav M. Labunskyy
Publikováno v:
Proceedings of the National Academy of Sciences. 115:9586-9591
The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen in Saccharomyces cerevisia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38233f581a6c447e4718d8b503dc7b2
https://doi.org/10.1073/pnas.1804264115
https://doi.org/10.1073/pnas.1804264115
Autor:
Matt Kaeberlein, Daniel T. Carr, Michael G. Kiflezghi, Margarete D. Moore, Mitchell B. Lee, Mary Ann K. Li, Socheata Thon, Yan Ting Zhao, Deborah B. Kim
Publikováno v:
GeroScience. 39:419-428
The mechanistic target of rapamycin (mTOR) is a central regulator of growth and proliferation and mTOR inhibition is a promising therapy for a variety of diseases and disorders. Inhibition of mTOR complex I (mTORC1) with rapamycin delays aging and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb225a6b8dfc24dc974720e419dc2cb8
https://doi.org/10.1007/s11357-017-9988-4
https://doi.org/10.1007/s11357-017-9988-4
Autor:
Matt Kaeberlein, Michael G. Kiflezghi
Publikováno v:
Innovation in Aging
Age is the main risk factor for cancer, cardiovascular disease, neurodegeneration and other diseases prevalent in the world’s aging population. These diseases increase the pain and suffering and result in billions of dollars in healthcare costs. Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02273421bb2588198cfdddb1512a7440
http://europepmc.org/articles/PMC6845562
http://europepmc.org/articles/PMC6845562