Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Michael G. Kemp"'
Autor:
William Cvammen, Michael G. Kemp
Publikováno v:
JID Innovations, Vol 4, Iss 6, Pp 100308- (2024)
Many aspects of skin biochemistry and physiology are known to vary over the course of the 24-hour day. Traditional approaches to study circadian rhythms in the skin have employed rodents or human subjects, which limit the experimental variables that
Externí odkaz:
https://doaj.org/article/24a30add3df44ca492955791f80c0f72
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102838- (2024)
Summary: UV radiation induces the formation of adducts in genomic DNA within cells that are later found to be present in cell-free fractions associated with extracellular vesicles (EVs) outside of cells. Here, we present a protocol for isolating UV p
Externí odkaz:
https://doaj.org/article/3d742588874d4152aaf02100ace7ef32
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Nucleotide excision repair (NER) and cell cycle checkpoints impact the ability of the anti-cancer drug cisplatin to inhibit cell proliferation and induce cell death. Genetic studies have shown that both NER and cell cycle progression are imp
Externí odkaz:
https://doaj.org/article/f2b3929afad44538b799891a484445ab
Autor:
Timothy C. Frommeyer, Craig A. Rohan, Dan F. Spandau, Michael G. Kemp, Molly A. Wanner, Elizabeth Tanzi, Jeffrey B. Travers
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
The occurrence of non-melanoma skin cancer (NMSC) is closely linked with advanced age and ultraviolet-B (UVB) exposure. More specifically, the development of NMSC is linked to diminished insulin-like growth factor-1 (IGF-1) signaling from senescent d
Externí odkaz:
https://doaj.org/article/436a0690d7574f35aa2dd2fc5a7f6e5b
Publikováno v:
JID Innovations, Vol 1, Iss 3, Pp 100023- (2021)
Spironolactone (SP) is used to treat a variety of disparate disease states ranging from heart failure to acne through antagonism of the mineralocorticoid and androgen receptors. Although normally taken as an oral medication, recent studies have explo
Externí odkaz:
https://doaj.org/article/f55855ea416b4f0fb5773e0a2674822d
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 756 (2020)
Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also antagonizes the androgen receptor, and thus SP has also been shown
Externí odkaz:
https://doaj.org/article/50cb66745c914d958375874a3b4730f4
Publikováno v:
Molecules, Vol 22, Iss 3, p 356 (2017)
The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to ultraviolet (UV) wavelengths of sunlight and age. Whereas UV radiation (UVR) has long been known to
Externí odkaz:
https://doaj.org/article/7479e7037d714ba9b5f8ddd1eb60ea5d
Autor:
Aziz Sancar, William K. Kaufmann, Stephanie L. Smith-Roe, Janiel M. Shields, Joyce T. Reardon, Michael G. Kemp, Shobhan Gaddameedhi
Sunlight UV exposure produces DNA photoproducts in skin that are repaired solely by nucleotide excision repair in humans. A significant fraction of melanomas are thought to result from UV-induced DNA damage that escapes repair; however, little eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c59592343e2d40bdbf255bc675aa357
https://doi.org/10.1158/0008-5472.c.6500036.v1
https://doi.org/10.1158/0008-5472.c.6500036.v1
Autor:
Aziz Sancar, William K. Kaufmann, Stephanie L. Smith-Roe, Janiel M. Shields, Joyce T. Reardon, Michael G. Kemp, Shobhan Gaddameedhi
Supplementary Table 1 from Similar Nucleotide Excision Repair Capacity in Melanocytes and Melanoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb57ed0ebdc10363f63f8eacdc0be74
https://doi.org/10.1158/0008-5472.22381940
https://doi.org/10.1158/0008-5472.22381940
Autor:
Aziz Sancar, William K. Kaufmann, Stephanie L. Smith-Roe, Janiel M. Shields, Joyce T. Reardon, Michael G. Kemp, Shobhan Gaddameedhi
Supplementary Figure Legends 1-6 from Similar Nucleotide Excision Repair Capacity in Melanocytes and Melanoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6554aad9fbe91fc0ffc72031f9e371f
https://doi.org/10.1158/0008-5472.22381946
https://doi.org/10.1158/0008-5472.22381946