Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Michael G. Dube"'
Publikováno v:
Peptides. 30:967-973
Enhanced long-term expression of leptin by gene therapy selectively in the hypothalamus, without leakage to the systemic circulation, abrogated skeletal abnormalities and reinstated weight and insulin–glucose homeostasis in leptin-deficient ob/ob m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d17cc57804c2e7a2fda99803cbd540
https://doi.org/10.1016/j.peptides.2009.01.020
https://doi.org/10.1016/j.peptides.2009.01.020
Autor:
Michael G. Dube, Satya P. Kalra, Urszula T. Iwaniec, H. Song, Stéphane Boghossian, William G. Helferich, Russell T. Turner
Publikováno v:
Bone. 44:404-412
Obesity in humans is associated with increased bone mass. Leptin, a hormone produced by fat cells, functions as a sentinel of energy balance, and may mediate the putative positive effects of body mass on bone. We performed studies in male C57Bl/6 wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513aa1f0304348ee254c85b6101a34cb
https://doi.org/10.1016/j.bone.2008.10.058
https://doi.org/10.1016/j.bone.2008.10.058
Autor:
Leonard G. Meggs, Satya P. Kalra, Maha Abdellatif, Michael G. Dube, Ashwani Malhotra, Virendra S Yadav, Himanshu Vashistha
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 296:H380-H388
Apoptotic myocyte cell death, diastolic dysfunction, and progressive deterioration in left ventricular pump function characterize the clinical course of diabetic cardiomyopathy. A key question concerns the mechanism(s) by which hyperglycemia (HG) tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae803c59031bf321685533a83554deb7
https://doi.org/10.1152/ajpheart.00225.2008
https://doi.org/10.1152/ajpheart.00225.2008
Publikováno v:
Peptides. 28:475-479
States of increased metabolic demand are associated with up-regulation of NPY and hyperphagia. However, we present some instances of hyperphagia in which NPY is not up-regulated. Ablation or functional disruption of specific sites in the hypothalamus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9ba4f8dda21afc15a46b41a8fd149b
https://doi.org/10.1016/j.peptides.2006.10.017
https://doi.org/10.1016/j.peptides.2006.10.017
Autor:
Urszula T. Iwaniec, Xiaoying Zhong, Carmen P. Wong, Mercedes F. Kweh, Iske V. Larkin, Michael G. Dube, Satya P. Kalra, Dawn A. Olson, Adam J. Branscum, Russell T. Turner, Thomas J. Wronski, Clifford J. Rosen
Publikováno v:
The Journal of endocrinology. 227(3)
Excessive weight gain in adults is associated with a variety of negative health outcomes. Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b2f6acce333434c43b9c6ac2e205b3
https://pubmed.ncbi.nlm.nih.gov/26487675
https://pubmed.ncbi.nlm.nih.gov/26487675
Publikováno v:
Peptides. 27:3245-3254
The effects of sustained leptin action locally in the hypothalamus on the functional link between fat accrual and insulin secretion after chronic high fat diet (HFD) consumption in leptin-deficient ob/ob mice, and on the post-prandial insulin respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0185e84636f2cd64182e64e49ccdbb4a
https://doi.org/10.1016/j.peptides.2006.07.022
https://doi.org/10.1016/j.peptides.2006.07.022
Publikováno v:
Obesity. 14:1312-1319
Objective: In this study, we tested the hypothesis that insufficiency of leptin restraint in the hypothalamus is responsible for promoting weight gain and adiposity after ovariectomy (ovx). Whether increasing leptin transgene expression can overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724b76c12b82a06e4202d088e0264b4a
https://doi.org/10.1038/oby.2006.149
https://doi.org/10.1038/oby.2006.149
Publikováno v:
Obesity. 14:1003-1009
Objective: Increased leptin transgene expression locally in hypothalamic sites suppresses weight and energy intake, enhances thermogenic energy expenditure, and differentially modulates metabolic hormones for an extended period. We evaluated whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b116054058b061f323c4a2a28505a1d7
https://doi.org/10.1038/oby.2006.115
https://doi.org/10.1038/oby.2006.115
Publikováno v:
Peptides. 26:1176-1187
The efficacy of central leptin therapy on weight homeostasis through various phases of reproduction, pregnancy outcome and postnatal, prepubertal and pubertal growth of offspring was assessed. Enhanced leptin transgene expression after a single intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614aae848021ca12ff4c2c961ca23dbd
https://doi.org/10.1016/j.peptides.2005.01.021
https://doi.org/10.1016/j.peptides.2005.01.021
Publikováno v:
Obesity Research. 13:991-999
Objective: Sprague-Dawley rats fed a high-fat diet (HFD) are either obesity prone (OP) or obesity resistant (OR). We tested the hypothesis that differences in the ultradian rhythmic patterns of insulin and ghrelin in OP vs. OR rats promote obesity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d94ee65595e7201e2545e713f9d58b6
https://doi.org/10.1038/oby.2005.116
https://doi.org/10.1038/oby.2005.116