Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michael G. Collis"'
Autor:
Paul V. Fish, Gavin A. Whitlock, Doris Greiling, Simon Bailey, Michael G. Collis, Jackie Diane Kendall, Julian Blagg, Andrew B. McElroy, Kim James, Rob Webster, Dawn Mccleverty, Gillian A. Allan, Charlotte Reed, Richard P. Butt
Publikováno v:
Journal of Medicinal Chemistry. 50:3442-3456
6-Cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamides were previously disclosed as inhibitors of procollagen C-proteinase (PCP) culminating in the identification of amide 1. Our objective was to discover a second inhibitor that would have improv
Publikováno v:
Trends in Pharmacological Sciences. 14:361-366
The numerous and widespread effects of adenosine provide both an opportunity for the development of novel therapeutic agents acting via adenosine receptors and the challenge of achieving selectivity of action. The feasibility of achieving selectivity
Autor:
Michael G Collis
Publikováno v:
Nucleosides and Nucleotides. 10:1057-1066
Adenosine receptors in isolated tissues from guinea-pigs have been investigated using agonists and antagonists. The receptor mediating decreases in rate and force of contraction of the atria is of the A1 sub-type. Responses of smooth muscle preparati
Autor:
Elizabeth King, Paul V. Fish, Rob Webster, Christopher Phillips, Margaret O'Gara, David G. Brown, Brian Henry, Richard P. Butt, Barber Christopher Gordon, Dawn Mccleverty, Dickinson Roger Peter, Michael G. Collis, Fraser Stuart Mcintosh, Valerie A. Horne, John P. Huggins
Publikováno v:
Journal of medicinal chemistry. 50(10)
1-isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of this template has revealed that incorporation of a 7-sulfonamide group furnishes a new seri
Autor:
Michael G. Collis
Publikováno v:
Trends in pharmacological sciences. 27(3)
There have been enormous advances in medicine during the 75 years since the British Pharmacological Society (BPS) was established and there is clear evidence that the new drugs discovered during this period of time have had a dramatic effect on the l
Autor:
Paul C. Dent, Edward J. Johns, Dominique Hestin, Michael G. Collis, P. L. Barclay, Chunlong Huang, Chunhua Huang
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 17(9)
BACKGROUND: It is recognized that endothelins are released in response to hypoperfusion and anoxia of the kidney and may be responsible for the consequent deterioration in renal function. This study examined the ability of a non-selective (SB209670)
Publikováno v:
European journal of pharmacology. 301(1-3)
The in vivo characterisation of ZM 241385 (4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-+ ++ylamino] ethyl)phenol), a novel, non-xanthine, selective adenosine A2A antagonist is described. In anaesthetised dogs ZM 241385 (i.v.) was
Autor:
Leonard P. Miller, Michael Williams, Akira Karasawa, Trevor W. Stone, Michael G. Collis, D. Hillaire-Buys
Publikováno v:
Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s ISBN: 9783034872201
The presence of all four types of adenosine receptor, A,, A2a, A2b and A3, in the cardiovascular system raises the possibility of developing adenosine analogues for use in a variety of clinical disorders. The production of anginal pain and tachyphyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904e4580b10ddf84714ab884402ba29a
https://doi.org/10.1007/978-3-0348-7218-8_30
https://doi.org/10.1007/978-3-0348-7218-8_30
Publikováno v:
General pharmacology. 25(7)
1. Adenosine and its analogues relaxed the isolated rat aorta by an endothelium-dependent mechanism with an order of potency of 5'-N-ethylcarboxamidoadenosine (NECA) > 2-(p-(2-carboxy-ethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosi ne (CGS 21680)
Autor:
Paul V. Fish, Christopher G. Barber, David G. Brown, Richard Butt, Michael G. Collis, Roger P. Dickinson, Brian T. Henry, Valerie A. Horne, John P. Huggins, Elizabeth King, Margaret O'Gara, Dawn McCleverty, Fraser McIntosh, Christopher Phillips, Robert Webster
Publikováno v:
Journal of Medicinal Chemistry; May2007, Vol. 50 Issue 10, p2341-2351, 11p