Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Michael G. Organ"'
Autor:
Volodymyr Semeniuchenko, Michael G. Organ, Norman Townsend, Sepideh Sharif, Aliakbar Mohammadzadeh, Andrew D. Corbett
Publikováno v:
Journal of Flow Chemistry. 12:131-140
A reactor has been designed specifically to conduct lithium aluminum hydride reductions in flow. The reactor readily accommodates strong hydrogen gas evolution and allows strict control over the combination of starting material and reductant, the rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4b3d899539088b09faa8690ac43230
https://doi.org/10.1007/s41981-021-00201-1
https://doi.org/10.1007/s41981-021-00201-1
Publikováno v:
Organometallics. 40:3276-3290
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b481cb29d171a262998934f9528ea0d4
https://doi.org/10.1021/acs.organomet.1c00386
https://doi.org/10.1021/acs.organomet.1c00386
Autor:
Jonathan Day, Sara S. El Zahed, Chris Bon, Natalie C. J. Strynadka, Michael G. Organ, Eric D. Brown, Maya A. Farha, Sean D. Workman
Publikováno v:
Journal of Medicinal Chemistry. 64:13540-13550
The polyprenyl lipid undecaprenyl phosphate (C55P) is the universal carrier lipid for the biosynthesis of bacterial cell wall polymers. C55P is synthesized in its pyrophosphate form by undecaprenyl pyrophosphate synthase (UppS), an essential cis-pren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4907d8c30130dc54dbd15bd22a0c6d28
https://doi.org/10.1021/acs.jmedchem.1c00941
https://doi.org/10.1021/acs.jmedchem.1c00941
Publikováno v:
Chemistry – A European Journal. 27:12535-12539
NaBHT (sodium 2,6-di-tert-butyl-4-methylphenolate), a strong, but hindered and lipophilic base, has been effectively paired with similarly lipophilic, high-reactivity Pd-NHC (N-heterocyclic carbene) catalysts to produce an ideal combination for perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0765f41d20b5ccc26073eaecb021c6be
https://doi.org/10.1002/chem.202101617
https://doi.org/10.1002/chem.202101617
Autor:
Jeffrey M. Manthorpe, Jonathan Day, Volodymyr Semeniuchenko, Sepideh Sharif, William J. Pietro, Michael G. Organ, Nalin Chandrasoma, Wilfried M. Braje
Publikováno v:
The Journal of Organic Chemistry. 86:10343-10359
(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free ("melt") conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa9bf8adc9f84f4e06133833f094faf
https://doi.org/10.1021/acs.joc.1c01057
https://doi.org/10.1021/acs.joc.1c01057
Publikováno v:
Angewandte Chemie. 133:20774-20794
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9030cead380e56b4389983a24d237b50
https://doi.org/10.1002/ange.202102009
https://doi.org/10.1002/ange.202102009
Publikováno v:
Analytical Chemistry. 93:3905-3913
Chiral active pharmaceutical ingredients (APIs) are known to bind to chiral biological targets with better on-target specificity than achiral ones. However, the methods of synthesizing such APIs stereoselectively require the exhaustive optimization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4153fd9ecb7f85913e4867397acddb6
https://doi.org/10.1021/acs.analchem.0c04652
https://doi.org/10.1021/acs.analchem.0c04652
Autor:
Debasis Mallik, Jeffrey M. Manthorpe, Wenyao Zhang, Mathieu A. Morin, William J. Pietro, Michael G. Organ
Publikováno v:
Chemistry–Methods. 1:131-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719ab1b4a2524f9f4868534061783605
https://doi.org/10.1002/cmtd.202100003
https://doi.org/10.1002/cmtd.202100003
Publikováno v:
Chemistry – A European Journal. 27:3855-3860
Two similar tridentate directing groups derived from glycine and 8-aminoquinoline were shown to enable the palladium-catalyzed anti-Markovnikov hydrofunctionalization of 4-pentenylamine with drastically different efficiencies. A computational investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be44822b32b9b271a4028cec65b591c
https://doi.org/10.1002/chem.202004881
https://doi.org/10.1002/chem.202004881
Autor:
Michael G. Organ, Philip Eckert
Publikováno v:
Chemistry – A European Journal. 26:4861-4865
The role that LiBr plays in the lifetime of Pd-NHC complexes has been investigated. A bromide ion is proposed to coordinate to Pd thereby preventing beta hydride elimination (BHE) (to form NHC-H+ ) of the reductive elimination (RE) intermediate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b5e3d95d9e61737e8d602204fea8d3
https://doi.org/10.1002/chem.202000288
https://doi.org/10.1002/chem.202000288