Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Michael G. Leeming"'
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Nicholas Williamson, Bill C.H. Chang, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100534- (2024)
Infections and diseases caused by parasitic nematodes have a major adverse impact on the health and productivity of animals and humans worldwide. The control of these parasites often relies heavily on the treatment with commercially available chemica
Externí odkaz:
https://doaj.org/article/e3738831bebf4b19be4951ffbbc3215f
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 24, Iss , Pp 100522- (2024)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against
Externí odkaz:
https://doaj.org/article/bd1202bcf63a4ff0ade2f378a914072b
Autor:
Aya C. Taki, Tao Wang, Nghi N. Nguyen, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Joseph J. Byrne, Neil D. Young, Yuanting Zheng, Guangxu Ma, Pasi K. Korhonen, Anson V. Koehler, Nicholas A. Williamson, Andreas Hofmann, Bill C. H. Chang, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these dru
Externí odkaz:
https://doaj.org/article/9c2e2b7509564909be768e1c02e98074
Autor:
Eve A. Maunders, Dalton H. Y. Ngu, Katherine Ganio, Sheikh I. Hossain, Bryan Y. J. Lim, Michael G. Leeming, Zhenyao Luo, Aimee Tan, Evelyne Deplazes, Boštjan Kobe, Christopher A. McDevitt
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Acquisition of the trace-element molybdenum via the high-affinity ATP-binding cassette permease ModABC is essential for Pseudomonas aeruginosa respiration in anaerobic and microaerophilic environments. This study determined the X-ray crystal structur
Externí odkaz:
https://doaj.org/article/709132d0eb6d4a8d995b370a195c263f
Autor:
Federico Martinez-Seidel, Pipob Suwanchaikasem, Shuai Nie, Michael G. Leeming, Alexandre Augusto Pereira Firmino, Nicholas A. Williamson, Joachim Kopka, Ute Roessner, Berin A. Boughton
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Due to their sessile nature, plants rely on root systems to mediate many biotic and abiotic cues. To overcome these challenges, the root proteome is shaped to specific responses. Proteome-wide reprogramming events are magnified in meristems due to th
Externí odkaz:
https://doaj.org/article/f87cf1cdfaea410c9ad5d579acff199f
Autor:
Paul D. Veith, Mikio Shoji, Richard A. J. O’Hair, Michael G. Leeming, Shuai Nie, Michelle D. Glew, Gavin E. Reid, Koji Nakayama, Eric C. Reynolds
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Porphyromonas gingivalis and Tannerella forsythia use the type IX secretion system to secrete cargo proteins to the cell surface where they are anchored via glycolipids. In P. gingivalis, the glycolipid is anionic lipopolysaccharide (A-LPS),
Externí odkaz:
https://doaj.org/article/fb654876e30d46e7ac470725d551babe
Autor:
Michael G. Leeming, Andrew P. Isaac, Luke Zappia, Richard A.J. O’Hair, William A. Donald, Bernard J. Pope
Publikováno v:
SoftwareX, Vol 12, Iss , Pp 100559- (2020)
The identification of metabolites plays an important role in understanding drug efficacy and safety however these compounds are often difficult to identify in complex mixtures. One approach to identify drug metabolites involves utilising differential
Externí odkaz:
https://doaj.org/article/9d262ac641b94230a8142455002a4fc9
Autor:
S. Sadia Ameen, Nane Griem-Krey, Antoine Dufour, M. Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik F. Draxler, Robert L. Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bokhari, Carli L. Roulston, Prasad N. Paradkar, Oded Kleifeld, Andrew N. Clarkson, Petrine Wellendorph, Giuseppe D. Ciccotosto, Nicholas A. Williamson, Ching-Seng Ang, Heung-Chin Cheng
Publikováno v:
Ameen, S S, Griem-Krey, N, Dufour, A, Hossain, M I, Hoque, A, Sturgeon, S, Nandurkar, H, Draxler, D F, Medcalf, R L, Kamaruddin, M A, Lucet, I S, Leeming, M G, Liu, D, Dhillon, A, Lim, J P, Basheer, F, Zhu, H J, Bokhari, L, Roulston, C L, Paradkar, P N, Kleifeld, O, Clarkson, A N, Wellendorph, P, Ciccotosto, G D, Williamson, N A, Ang, C S & Cheng, H C 2023, ' N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection ', Molecular & cellular proteomics : MCP, vol. 22, no. 5, 100543 . https://doi.org/10.1016/j.mcpro.2023.100543
Molecular & cellular proteomics : MCP, vol 22, iss 5
Molecular & cellular proteomics : MCP, vol 22, iss 5
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity, the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a980e6e528169653b1b0ed50175569
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf
Publikováno v:
Bioinformatics Advances. 3
Motivation A large number of experimental and bioinformatic parameters must be set to identify and quantify peptides in mass spectrometry experiments and each of these will impact the results. An ability to simulate raw data with known contents would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aef950b5387a15c569ffe25cff14e210
https://doi.org/10.1093/bioadv/vbac096
https://doi.org/10.1093/bioadv/vbac096
Autor:
Federico Martinez-Seidel, Pipob Suwanchaikasem, Dione Gentry-Torfer, Yogeswari Rajarathinam, Alina Ebert, Alexander Erban, Alexandre Augusto Pereira Firmino, Shuai Nie, Michael G. Leeming, Nicholas A. Williamson, Ute Roessner, Joachim Kopka, Berin A. Boughton
Plant acclimation to low temperatures occurs through system-wide mechanisms that include proteome shifts, some of which occur at the level of protein synthesis. All proteins are synthesised by ribosomes. Rather than being monolithic, transcript-to-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c946a14c8aa4775e714ed74793d5a15
https://doi.org/10.1101/2022.11.28.518201
https://doi.org/10.1101/2022.11.28.518201