Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael G Sugiyama"'
Autor:
Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa CB Oliveira, Aisha N Rekab, Mathieu JF Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia LM Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan
Publikováno v:
eLife, Vol 12 (2024)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be cau
Externí odkaz:
https://doaj.org/article/56671c5952a34e068944e75893122071
Autor:
Dana Praslickova, Enrique C Torchia, Michael G Sugiyama, Elijah J Magrane, Brittnee L Zwicker, Lev Kolodzieyski, Luis B Agellon
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50810 (2012)
The ileal lipid binding protein (ilbp) is a cytoplasmic protein that binds bile acids with high affinity. However evidence demonstrating the role of this protein in bile acid transport and homeostasis is missing. We created a mouse strain lacking ilb
Externí odkaz:
https://doaj.org/article/a8e76d246a484f5ab6471b2854d4f9b2
Autor:
Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronavi
Externí odkaz:
https://doaj.org/article/6fc7b459daf94a499be2325b0bbff79f
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology that is stimulated by multiple distinct ligands. Although ligands bind to EGFR while the receptor is exposed on the plasma membrane, EGFR incorporation into endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4e041061d47d780fb2239428ebab3
https://doi.org/10.1101/2023.05.09.539827
https://doi.org/10.1101/2023.05.09.539827
Autor:
Costin N. Antonescu, Bo Wang, Stephen S. MacKinnon, Vijay Shahani, Jean-Philippe Julien, Andreas Windemuth, Seyed Ali Madani Tonekaboni, Gregory D. Fairn, Sarah A. Sabatinos, Raffi Karshafian, Roberto Botelho, Andrew Haller, Russell D. Viirre, Joseph B. McPhee, Rahul Misra, Kyle Cheung, Sikander Hayat, Hassaan Maan, Edurne Rujas, Mehran Karimzadeh, Dar’ya S. Redka, Haotian Cui, Michael G. Sugiyama
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a129474d5f09baee846b06163aa1f9
https://doi.org/10.32920/21982913.v1
https://doi.org/10.32920/21982913.v1
Autor:
Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams, Anne Eichmann, Warren L. Lee, Carlos Fernández-Hernando, William C. Sessa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggestin
Externí odkaz:
https://doaj.org/article/745c383654124c2b97ea3d105429cf8d
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently confined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4614643903688f8e1ce90512815ae3cb
Autor:
Peter King, Clare E. Futter, Costin N. Antonescu, Mikkel W. Pedersen, Daniel Hochhauser, John A. Hartley, Michael Kragh, Sylwia Jones, Nicos Angelopoulos, Michael G. Sugiyama, Amandeep Bhamra, Silvia Surinova
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
Antibody combinations targeting cell surface receptors are a new modality of cancer therapy. The trafficking and signalling mechanisms regulated by such therapeutics are not fully understood but could underlie differential tumour responses. We explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64270284fb2877c32e0e4925e65ba4be
http://link.springer.com/article/10.1038/s41598-019-57153-9
http://link.springer.com/article/10.1038/s41598-019-57153-9
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently confined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a4c28baec0cf507dbb66aed378eb83
https://doi.org/10.1101/2022.03.04.483015
https://doi.org/10.1101/2022.03.04.483015
Autor:
Warren L. Lee, Heino Velazquez, George Tellides, Martin A. Schwartz, Chirosree Bandyopadhyay, Michael G. Sugiyama, Carlos Fernández-Hernando, Jan R. Kraehling, Miguel A. Lasunción, Victoria Ulrich, William C. Sessa, Shun He, Cristina M. Ramírez, Chin Sheng Lin, Guangxin Li, Yajaira Suárez, Noemi Rotllan, Xinran Liu, Xinbo Zhang, Filip K. Swirski, Binod Aryal
Publikováno v:
Circulation. 140:225-239
Background: Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated that absence of caveolin-1 (Cav1)/caveolae in hyperlipidemic mice stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::587719f11592032563c070a7b1366c39
https://doi.org/10.1161/circulationaha.118.038571
https://doi.org/10.1161/circulationaha.118.038571