Výsledky vyhledávání - "Michael G Roth"

Akademický článek

TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.

Autor: Balajee R Somalinga, Cameron E Day, Shuguang Wei, Michael G Roth, Philip J Thomas

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35818 (2012)

Amyotrophic Lateral Sclerosis (ALS) is a late-onset, progressive neurodegenerative disease affecting motor neurons in the brain stem and spinal cord leading to loss of voluntary muscular function and ultimately, death due to respiratory failure. A su

Externí odkaz: https://doaj.org/article/2c1e6fe80ebf4a7f82be020bdb4e0f02

Zobrazit plný text záznamu

Akademický článek

Host modulators of H1N1 cytopathogenicity.

Autor: Samuel E Ward, Hyun Seok Kim, Kakajan Komurov, Saurabh Mendiratta, Pei-Ling Tsai, Mirco Schmolke, Neal Satterly, Balaji Manicassamy, Christian V Forst, Michael G Roth, Adolfo García-Sastre, Katarzyna M Blazewska, Charles E McKenna, Beatriz M Fontoura, Michael A White

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e39284 (2012)

Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccin

Externí odkaz: https://doaj.org/article/c5ff6c95095346579020db8ad8961ee7

Zobrazit plný text záznamu

Akademický článek

The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1.

Autor: Ka Yu Siu, Mei Kuen Yu, Xinggang Wu, Min Zong, Michael G Roth, Hsiao Chang Chan, Sidney Yu

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18458 (2011)

The regulation of the actin cytoskeleton and membrane trafficking is coordinated in mammalian cells. One of the regulators of membrane traffic, the small GTP-binding protein ARF1, also activates phosphatidylinositol kinases that in turn affect actin

Externí odkaz: https://doaj.org/article/6853e97054564cf785bb391d46bd93b6

Zobrazit plný text záznamu

Akademický článek

Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.

Autor: Sarah Straud, Iryna Zubovych, Jef K De Brabander, Michael G Roth

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11629 (2010)

Many cell lines derived from tumors as well as transformed cell lines are far more sensitive to V-ATPase inhibitors than normal counterparts. The molecular mechanisms underlying these differences in sensitivity are not known. Using global gene expres

Externí odkaz: https://doaj.org/article/19230cabd779487c980ebe8a0491b671

Zobrazit plný text záznamu

Akademický článek

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

Autor: Anand K Ganesan, Hsiang Ho, Brian Bodemann, Sean Petersen, Jayavani Aruri, Shiney Koshy, Zachary Richardson, Lu Q Le, Tatiana Krasieva, Michael G Roth, Pat Farmer, Michael A White

Publikováno v: PLoS Genetics, Vol 4, Iss 12, p e1000298 (2008)

Melanin protects the skin and eyes from the harmful effects of UV irradiation, protects neural cells from toxic insults, and is required for sound conduction in the inner ear. Aberrant regulation of melanogenesis underlies skin disorders (melasma and

Externí odkaz: https://doaj.org/article/6e8cb1d7e6c9434d943c7b29e3b17084

Zobrazit plný text záznamu

Akademický článek

Small molecule glucagon release inhibitors with activity in human islets

Autor: Michael A. Kalwat, Karina Rodrigues-dos-Santos, Derk D. Binns, Shuguang Wei, Anwu Zhou, Matthew R. Evans, Bruce A. Posner, Michael G. Roth, Melanie H. Cobb

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

PurposeType 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood glucose control is the major goal for individuals with T1D. In T1D, insulin-secretin

Externí odkaz: https://doaj.org/article/5b86bc5e2aad4d56b25d4ff17c19aa48

Zobrazit plný text záznamu

Akademický článek

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Autor: Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Lung cancers often harbour loss-of-function mutations inSMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.

Externí odkaz: https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání