Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Michael G Roper"'
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211832 (2019)
Pulsatile insulin secretion into the portal vein from the many pancreatic islets of Langerhans is critical for efficient glucose homeostasis. The islets are themselves endogenous oscillators, but since they are not physically coupled it is not obviou
Externí odkaz:
https://doaj.org/article/c10738feed71401baf941d02c59fc6cd
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Islets of Langerhans are a therapeutic target for diabetes and prediabetes. Measurements of therapeutic inhibitory or excitatory concentrations are often performed using large groups of islets, however, the population heterogeneity cannot be
Externí odkaz:
https://doaj.org/article/5e4792fedc6044029cdba06eddb4abdc
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 10, p e1005143 (2016)
Pancreatic islets manage elevations in blood glucose level by secreting insulin into the bloodstream in a pulsatile manner. Pulsatile insulin secretion is governed by islet oscillations such as bursting electrical activity and periodic Ca2+ entry in
Externí odkaz:
https://doaj.org/article/1f761626d24a441cbba37256639a2ee6
Autor:
Cindy J. Lee, Dong-Kyu Lee, I-An Wei, Tian A. Qiu, Stanislav S. Rubakhin, Michael G. Roper, Jonathan V. Sweedler
Publikováno v:
ACS Omega, Vol 8, Iss 50, Pp 47723-47734 (2023)
Externí odkaz:
https://doaj.org/article/09d93aef2c764d77ab3c0786ca830f9d
Publikováno v:
The Analyst. 148:1227-1234
To address flow control challenges in microfluidic systems with vacuum-driven flow, integrated valves and capacitors were used to deliver smooth stimulant profiles to murine islets of Langerhans for dynamic insulin secretion measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b17dc7d88771adb4baa924a05445b2
https://doi.org/10.1039/d2an01985j
https://doi.org/10.1039/d2an01985j
Autor:
Michael G. Roper, Wesley J. Eaton
Publikováno v:
Analytical Methods
Glucagon is a 29-amino acid peptide released from α-cells within pancreatic islets of Langerhans to help raise blood glucose levels. While a plethora of methodologies have been developed for quantitative measurement of insulin released from islets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f860356384b1a67b6c12ffb4dfcf50
http://europepmc.org/articles/PMC8375491
http://europepmc.org/articles/PMC8375491
Autor:
Emmanuel O. Ogunkunle, Matthew J. Donohue, Daniel J. Steyer, Damilola I. Adeoye, Wesley J. Eaton, Michael G. Roper
Publikováno v:
Analytical methods : advancing methods and applications. 14(21)
Islets of Langerhans are the endocrine tissue within the pancreas that secrete hormones for maintenance of blood glucose homeostasis. A variety of small molecules including classical neurotransmitters are also released from islets. While the roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2b0308b7537e78a076a25a57e5c893
https://pubmed.ncbi.nlm.nih.gov/35567801
https://pubmed.ncbi.nlm.nih.gov/35567801
Publikováno v:
Analytical Chemistry
Pulsatile insulin from pancreatic islets is crucial for glucose homeostasis, but the mechanism behind coordinated pulsatility is still under investigation. One hypothesis suggests that cholinergic stimulation of islets by pancreatic ganglia resets th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f6bf61cf8dd5915e1203c2455cd19c
https://doi.org/10.1021/acs.analchem.0c01226
https://doi.org/10.1021/acs.analchem.0c01226
Autor:
Michael G. Roper, Radha Krishna Murthy Bulusu, Nikita Mukhitov, Jose L. Mendoza-Cortes, Anna G. Adams
Publikováno v:
Analytical Chemistry
Hepatocytes help to maintain glucose homeostasis in response to a variety of signals, including pancreatic hormones such as insulin. Insulin is released from the pancreas with variable dynamics, yet the role that these play in regulating glucose meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ffad592c21652533d6e40b2885dc39
https://doi.org/10.1021/acs.analchem.8b05798
https://doi.org/10.1021/acs.analchem.8b05798
Publikováno v:
Islets
In vivo levels of insulin are oscillatory with a period of ~5–10 minutes, indicating that the islets of Langerhans within the pancreas are synchronized. While the synchronizing factors are still under investigation, one result of this behavior is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3610c05b02c1afb3cbf138c3e29d3acc
https://doi.org/10.1080/19382014.2019.1581544
https://doi.org/10.1080/19382014.2019.1581544