Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Michael G Natchus"'
Autor:
Carolin M Lieber, Hae-Ji Kang, Megha Aggarwal, Nicole A Lieberman, Elizabeth B Sobolik, Jeong-Joong Yoon, Michael G Natchus, Robert M Cox, Alexander L Greninger, Richard K Plemper
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011993 (2024)
Pre-existing or rapidly emerging resistance of influenza viruses to approved antivirals makes the development of novel therapeutics to mitigate seasonal influenza and improve preparedness against future influenza pandemics an urgent priority. We have
Externí odkaz:
https://doaj.org/article/117f31c4a45c47118cf8a1f7ce01ee9a
Autor:
Carolin M Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K Johnson, Cheryl A Jones, Zachary M Sticher, Alexander A Kolykhalov, Manohar T Saindane, Stephen M Tompkins, Oliver Planz, George R Painter, Michael G Natchus, Kaori Sakamoto, Richard K Plemper
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011342 (2023)
Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential
Externí odkaz:
https://doaj.org/article/6936c60659ba4a96b921b668517dfbee
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009371 (2021)
Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations. ERDRP-0519, a pan-morbillivi
Externí odkaz:
https://doaj.org/article/92949f42620c4f69984e9de22c19a941
Autor:
Kevin Wittwer, Danielle E. Anderson, Kristin Pfeffermann, Robert M. Cox, Josef D. Wolf, Sabine Santibanez, Annette Mankertz, Roland Plesker, Zachary M. Sticher, Alexander A. Kolkykhalov, Michael G. Natchus, Christian K. Pfaller, Richard K. Plemper, Veronika von Messling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.
Externí odkaz:
https://doaj.org/article/5330f59bd9fe43ada6a0147032c636eb
Autor:
Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, Robert M. Cox, Josef D. Wolf, Jeong-Joong Yoon, Mart Toots, Chengin Ye, Zachary Sticher, Alexander A. Kolykhalov, Luis Martinez-Sobrido, Gregory R. Bluemling, Michael G. Natchus, George R. Painter, Richard K. Plemper
Publikováno v:
bioRxiv
Science
Science
The COVID-19 pandemic has underscored the critical need for broad-spectrum therapeutics against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric patients and the elderly. We describe 4’-fluorouridine (4’-FlU,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a490333684dc23dc48664090d7f06
https://pubmed.ncbi.nlm.nih.gov/34031658
https://pubmed.ncbi.nlm.nih.gov/34031658
Autor:
Robert M Cox, Carolin M Lieber, Josef D Wolf, Amirhossein Karimi, Nicole A P Lieberman, Zachary M Sticher, Pavitra Roychoudhury, Meghan K Andrews, Rebecca E Krueger, Michael G Natchus, George R Painter, Alexander A Kolykhalov, Alexander L Greninger, Richard K Plemper
Publikováno v:
bioRxiv
Despite the continued spread of SARS-CoV-2 and emergence of variants of concern (VOC) that are capable of escaping preexisting immunity, therapeutic options are underutilized. In addition to preventing severe disease in high-risk patients, antivirals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d826bcf5816628c7ba9b71dc6797bf6
https://pubmed.ncbi.nlm.nih.gov/36451893
https://pubmed.ncbi.nlm.nih.gov/36451893
Autor:
Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar T. Saindane, Stephen M. Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper
Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4a0e6406c62c40e4bba51689586e8
https://doi.org/10.1101/2022.11.05.515296
https://doi.org/10.1101/2022.11.05.515296
Autor:
Gregory R. Bluemling, Shuli Mao, Michael G. Natchus, Wendy Painter, Sabue Mulangu, Mark Lockwood, Abel De La Rosa, Trevor Brasel, Jason E. Comer, Alexander N. Freiberg, Alexander A. Kolykhalov, George R. Painter
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11,000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional >3400 cases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54dc3248a92fa332815e96410974c759
https://doi.org/10.1101/2022.10.18.512767
https://doi.org/10.1101/2022.10.18.512767
Autor:
Gregory R, Bluemling, Shuli, Mao, Michael G, Natchus, Wendy, Painter, Sabue, Mulangu, Mark, Lockwood, Abel, De La Rosa, Trevor, Brasel, Jason E, Comer, Alexander N, Freiberg, Alexander A, Kolykhalov, George R, Painter
Publikováno v:
Antiviral research. 209
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11 000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional3400 cases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54c76b10578980536022477c62606374
https://pubmed.ncbi.nlm.nih.gov/36379378
https://pubmed.ncbi.nlm.nih.gov/36379378
Autor:
Carolin M. Lieber, Robert M. Cox, Julien Sourimant, Josef D. Wolf, Kate Juergens, Quynh Phung, Manohar T. Saindane, Meghan K. Smith, Zachary M. Sticher, Alexander A. Kalykhalov, Michael G. Natchus, George R. Painter, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
bioRxiv
SARS-CoV-2 variants of concern (VOC) have triggered distinct infection waves in the coronavirus disease 2019 (COVID-19) pandemic, culminating in currently all-time high incidence rates of VOC omicron. Orally available direct-acting antivirals such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7581141689e41f8825d22e9dfed99e98
https://doi.org/10.1038/s41467-022-32045-1
https://doi.org/10.1038/s41467-022-32045-1