A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.

Autor: Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010113 (2022)

The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated wi

Externí odkaz: https://doaj.org/article/ffdb9e4bf94d4c729a4428cb28eaf0c9

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study.

Autor: Michael G Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Shefali S Verma, Yuki Bradford, Regeneron Genetics Center, Marylyn D Ritchie, Matthew C Hyman, Saman Nazarian, Daniel J Rader, Benjamin F Voight, Scott M Damrauer

Publikováno v: PLoS Medicine, Vol 17, Iss 10, p e1003288 (2020)

BackgroundObservational studies have identified height as a strong risk factor for atrial fibrillation, but this finding may be limited by residual confounding. We aimed to examine genetic variation in height within the Mendelian randomization (MR) f

Externí odkaz: https://doaj.org/article/ec5d62fe5a9a40349958459a8438e942

Genetics of atrial fibrillation

Autor: David S.M. Lee, Scott M. Damrauer, Michael G. Levin

Publikováno v: Current Opinion in Cardiology. 38:162-168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1038dac09f27f91b5548b6ca3e55469e
https://doi.org/10.1097/hco.0000000000001031

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Autor: Florian, Thibord, Derek, Klarin, Jennifer A, Brody, Ming-Huei, Chen, Michael G, Levin, Daniel I, Chasman, Ellen L, Goode, Kristian, Hveem, Maris, Teder-Laving, Angel, Martinez-Perez, Dylan, Aïssi, Delphine, Daian-Bacq, Kaoru, Ito, Pradeep, Natarajan, Pamela L, Lutsey, Girish N, Nadkarni, Paul S, de Vries, Gabriel, Cuellar-Partida, Brooke N, Wolford, Jack W, Pattee, Charles, Kooperberg, Sigrid K, Braekkan, Ruifang, Li-Gao, Noemie, Saut, Corriene, Sept, Marine, Germain, Renae L, Judy, Kerri L, Wiggins, Darae, Ko, Christopher J, O'Donnell, Kent D, Taylor, Franco, Giulianini, Mariza, De Andrade, Therese H, Nøst, Anne, Boland, Jean-Philippe, Empana, Satoshi, Koyama, Thomas, Gilliland, Ron, Do, Jennifer E, Huffman, Xin, Wang, Wei, Zhou, Jose, Manuel Soria, Juan, Carlos Souto, Nathan, Pankratz, Jeffery, Haessler, Kristian, Hindberg, Frits R, Rosendaal, Constance, Turman, Robert, Olaso, Rachel L, Kember, Traci M, Bartz, Julie A, Lynch, Susan R, Heckbert, Sebastian M, Armasu, Ben, Brumpton, David M, Smadja, Xavier, Jouven, Issei, Komuro, Katharine R, Clapham, Ruth J F, Loos, Cristen J, Willer, Maria, Sabater-Lleal, James S, Pankow, Alexander P, Reiner, Vania M, Morelli, Paul M, Ridker, Astrid van Hylckama, Vlieg, Jean-François, Deleuze, Peter, Kraft, Daniel J, Rader, Kyung, Min Lee, Bruce M, Psaty, Anne, Heidi Skogholt, Joseph, Emmerich, Pierre, Suchon, Stephen S, Rich, Ha My T, Vy, Weihong, Tang, Rebecca D, Jackson, John-Bjarne, Hansen, Pierre-Emmanuel, Morange, Christopher, Kabrhel, David-Alexandre, Trégouët, Scott M, Damrauer, Andrew D, Johnson, Nicholas L, Smith

Publikováno v: Circulation
Circulation, 2022, 146 (16), ⟨10.1161/CIRCULATIONAHA.122.059675⟩
CIRCULATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386371a640cbbdf582ab7affdb48ca95
https://doi.org/10.1161/circulationaha.122.059675

Evaluation of plasma biomarkers for causal association with peripheral artery disease

Autor: Pranav Sharma, Michael G. Levin, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Scott M. Damrauer

BackgroundHundreds of biomarkers for Peripheral artery disease (PAD) have been reported in the literature, however, the observational nature these studies limit robust causal inference due to the potential of reverse causality and confounding. We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::995a5ea6d796234de0a5a102ad0ee151
https://doi.org/10.1101/2023.05.05.23289560