Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Michael G Lerner"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012195 (2024)
Therapeutic interventions are designed to perturb the function of a biological system. However, there are many types of proteins that cannot be targeted with conventional small molecule drugs. Accordingly, many identified gene-regulatory drivers and
Externí odkaz:
https://doaj.org/article/02ea3ba2e69f4ad4996c9faec1975b45
Autor:
Frank C Pickard, Benjamin T Miller, Vinushka Schalk, Michael G Lerner, H Lee Woodcock, Bernard R Brooks
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003738 (2014)
A lesson utilizing a coarse-grained (CG) Gō-like model has been implemented into the CHARMM INterface and Graphics (CHARMMing) web portal (www.charmming.org) to the Chemistry at HARvard Macromolecular Mechanics (CHARMM) molecular simulation package.
Externí odkaz:
https://doaj.org/article/9535e63085cd44e6afb6cd086315db2c
Autor:
Ling Li, Gilad Halpert, Michael G. Lerner, Haijie Hu, Peter Dimitrion, Matthew J. Weiss, Jin He, Benjamin Philosophe, Richard Burkhart, William R. Burns, Russell N. Wesson, Andrew MacGregor Cameron, Christopher L. Wolfgang, Christos Georgiades, Satomi Kawamoto, Nilofer S. Azad, Mark Yarchoan, Stephen J. Meltzer, Kiyoko Oshima, Laura M. Ensign, Joel S. Bader, Florin M. Selaru
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Hepatocellular carcinoma (HCC) is the sixth most common and the fourth most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC models in whic
Externí odkaz:
https://doaj.org/article/f683fedaae0d4fbb8bdd07f74ee54fb0
Autor:
Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, Benedict Kinny-Köster, Jacquelyn W. Zimmerman, Genevieve Stein-O’Brien, Matthias M. Gaida, James R. Eshleman, Ming-Tseh Lin, Elana J. Fertig, Andrew J. Ewald, Joel S. Bader, Laura D. Wood
Publikováno v:
Journal of Clinical Investigation. 133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f07836e6009a008def57778666a4a89
https://doi.org/10.1172/jci162054
https://doi.org/10.1172/jci162054
Autor:
Filemon S. Dela Cruz, Hiroyuki Yoda, Calvin J. Kuo, William C. Hahn, Kelly Kersten, Olivier Gevaert, Michitaka Nakano, Bruce K. Hua, Yohannes Tsehay, Han Liang, Yun Rose Li, Taofeek K. Owonikoko, Yunqi Yan, Katherine N. Liu, Stephen E. Kurtz, Andrew J. Ewald, Gordon B. Mills, Matthew Dunworth, Yuhao Wang, Eloise M. Grasset, Joseph Estabrook, Nicola Long, Vasanthi S. Viswanathan, Bridget Robinson, Shubhroz Gill, Matthew C. Perrone, Ken Chen, Suresh S. Ramalingam, Robert T. Manguso, Asmita Bhattacharya, Andrea Califano, Wei Zhou, Yuhong Du, Elodie Henriet, Jordana Brown, Francisca Vazquez, Michael T. McManus, Manisha Warrier, Gabriel Eades, Anuja Sathe, Yilong Zou, Yoko Kosaka, Matthew A. Reyna, Theodore P. Braun, Daniela S. Gerhard, Matthew F. Krummel, Allan Balmain, Tamilla Nechiporuk, Hanlee P. Ji, Quin Morrow, Emek Demir, Pablo Tamayo, Jessica Minnier, Michael C. Bassik, Kevin Watanabe-Smith, Xiulei Mo, Qi-Wen Fan, Nicole Nasholm, Sagar Lonial, Stuart L. Schreiber, Brent R. Stockwell, Nina K. Serwas, Sourav Bandyopadhyay, Brian J. Druker, Christina Curtis, Yuan-Hung Lo, Olga Nikolova, Qiankun Niu, Veena Padmanaban, Yuchen Ge, Cristina E. Tognon, Anupriya Agarwal, Christopher J. Kemp, Kremena Karagyozova, Haian Fu, Trevor Bivona, Dan Georgess, Nidhi Sahni, Stefan Oberlin, Issac S. Chan, Michael G. Lerner, Matt Hangauer, Jennifer Saultz, Wing Hing Wong, Ilya Shmulevich, Christin Schmidt, Yasir Suhail, Andy Kaempf, Alan Ashworth, Saumya R. Bollam, Tanaz Sharifnia, Jesse S. Boehm, Kasper Karlsson, Carlos S. Moreno, Neil Tay, Michael Grzadkowski, Kevin C. Brennan, Subhashini Jagu, Elizabeth M. Swisher, Ben Deneen, Jessica A. Talamas, Amber R. Smith, Joel S. Bader, Vlado Dančík, Andrew L. Kung, William A. Weiss, Hildur Knutsdottir, Tania Q. Vu, Lee Cooper, Kanako Yuki, Wei-Ching Chen, Bridget K. Wagner, Evan F. Lind, Josh Dempster, Marie Menard, Carla Grandori, Andrey A. Ivanov, William Kim, Jeffrey W. Tyner, Jonathan S. Weissman, Thomas Jacob, Paul A. Clemons, Jitong Cai, Kaitlyn Spees, Dan S. Kaufman
Publikováno v:
Cell, vol 184, iss 5
Cell
Cell
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9eecba249a534391089dc341a11f66
https://doi.org/10.1016/j.cell.2021.02.020
https://doi.org/10.1016/j.cell.2021.02.020
Publikováno v:
American Journal of Political Science. 65:69-87
Which firms oppose action to fight climate change? Networks of input sourcing and sales to downstream customers ought to propagate and reinforce opposition to decarbonization beyond direct emitters of CO2. To test this claim, we build the largest dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c804d80c5f7ef50019be59aa0536909f
https://doi.org/10.1111/ajps.12525
https://doi.org/10.1111/ajps.12525
Autor:
Christos S. Georgiades, Satomi Kawamoto, Peter Dimitrion, Laura M. Ensign, Mark Yarchoan, Russell Wesson, Ling Li, William R. Burns, Nilofer S. Azad, Michael G. Lerner, Christopher L. Wolfgang, Haijie Hu, Kiyoko Oshima, Joel S. Bader, Jin He, Richard A. Burkhart, Gilad Halpert, Andrew M. Cameron, Stephen J. Meltzer, Florin M. Selaru, Benjamin Philosophe, Matthew J. Weiss
Publikováno v:
JCI Insight
Hepatocellular carcinoma (HCC) is the sixth most common and the fourth most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC models in whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaffb34cff0f36f9cf0d4f90251f153
https://doi.org/10.1172/jci.insight.138197
https://doi.org/10.1172/jci.insight.138197
Abstract 368: Defining the invasive gene signature using patient derived pancreatic cancer organoids
Autor:
Yea Ji Jeong, Joel S. Bader, Andrew J. Ewald, Hildur Knutsdottir, Laura D. Wood, Bernat Navarro-Serer, Peter Chianchiano, Yuchen Ge, Michael G. Lerner
Publikováno v:
Cancer Research. 80:368-368
Pancreatic cancer mortality is rising due to late detection and established metastasis. Despite the recent advances in cancer research, metastasis research has been hampered by the lack of models that recapitulate this complex process. Traditional ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0cd6a9c55c0e141f3d7da0cf9092f44
https://doi.org/10.1158/1538-7445.am2020-368
https://doi.org/10.1158/1538-7445.am2020-368
Publikováno v:
Nature. 564:39-39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99810a12d4e26090cb615572c44770dc
https://doi.org/10.1038/d41586-018-07610-8
https://doi.org/10.1038/d41586-018-07610-8
Publikováno v:
International Journal of Social Science Studies. 4
This paper assesses the influence of two reports, “The Limits to Growth” and “The Global 2000 Report to the President—Entering the Twenty-First Century,” on environmental governance in the United States. Published in 1972 and 1980, respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eebf96cb9a1992d530a89f5ce4e5d91
https://doi.org/10.11114/ijsss.v4i8.1674
https://doi.org/10.11114/ijsss.v4i8.1674