Výsledky vyhledávání - "Michael G Edwards"

Akademický článek

Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

Autor: Matthew A Burchill, Justin A Roby, Nanette Crochet, Megan Wind-Rotolo, Amy E Stone, Michael G Edwards, Rachael J Dran, Michael S Kriss, Michael Gale, Hugo R Rosen

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186213 (2017)

ResultsFirst, in patients receiving two different combinations of DAAs, we found that DAAs induced not only rapid viral clearance, but also a re-setting of antiviral immune responses in the peripheral blood. Specifically, we see a rapid decline in th

Externí odkaz: https://doaj.org/article/66720068face4cb0ad7a33940e4a2f9e

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Akademický článek

Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.

Autor: Olivia Hoffman, Nana Burns, István Vadász, Holger K Eltzschig, Michael G Edwards, Christine U Vohwinkel

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172116 (2017)

A hallmark of acute respiratory distress syndrome (ARDS) is accumulation of protein-rich edema in the distal airspaces and its removal is critical for patient survival. Previous studies have shown a detrimental role of Glycogen Synthase Kinase (GSK)

Externí odkaz: https://doaj.org/article/0edbf2a4de6a40559f59b9daa4abb3c2

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Akademický článek

Correction: Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.

Autor: Olivia Hoffman, Nana Burns, István Vadász, Holger K Eltzschig, Michael G Edwards, Christine U Vohwinkel

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176134 (2017)

[This corrects the article DOI: 10.1371/journal.pone.0172116.].

Externí odkaz: https://doaj.org/article/52871b57540049698ce4e218a2648706

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Akademický článek

Correction: Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.

Autor: Rachel H McMahan, Cara E Porsche, Michael G Edwards, Hugo R Rosen

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168301 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0159217.].

Externí odkaz: https://doaj.org/article/e270dc2a9fe848ceaf436c9e983887b9

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Akademický článek

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.

Autor: Lianghua Bin, Liehua Deng, Hengwen Yang, Leqing Zhu, Xiao Wang, Michael G Edwards, Brittany Richers, Donald Y M Leung

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167392 (2016)

The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription fa

Externí odkaz: https://doaj.org/article/6250573738a046caa25256af48e72982

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Akademický článek

Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.

Autor: Rachel H McMahan, Cara E Porsche, Michael G Edwards, Hugo R Rosen

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159217 (2016)

Non-alcoholic fatty liver disease is a prevalent problem throughout the western world. Liver sinusoidal endothelial cells (LSEC) have been shown to play important roles in liver injury and repair, but their role in the underlying pathogenetic mechani

Externí odkaz: https://doaj.org/article/fb9f10e214584787a35c7ce3c6b26e02

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Akademický článek

Delay modulates the immune response to nerve repair

Autor: Masoud Golshadi, Elaine F. Claffey, Jennifer K. Grenier, Andrew Miller, Michael Willand, Michael G. Edwards, Tim P. Moore, Michael Sledziona, Tessa Gordon, Gregory H. Borschel, Jonathan Cheetham

Publikováno v: npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-13 (2023)

Abstract Effective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within the macrophage population when repair is delayed and identified alteration of key upstream reg

Externí odkaz: https://doaj.org/article/8a4187182c5d41e5a6c313b2134e85a7

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