Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Michael G Acker"'
Autor:
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Publikováno v:
eLife, Vol 10 (2021)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Externí odkaz:
https://doaj.org/article/653eeb5ad6e5454e9488ec62514b8bc7
Autor:
Michael Brauchle, Zhiping Yao, Rishi Arora, Sachin Thigale, Ieuan Clay, Bruno Inverardi, Joy Fletcher, Paul Taslimi, Michael G Acker, Bertran Gerrits, Johannes Voshol, Andreas Bauer, Dirk Schübeler, Tewis Bouwmeester, Heinz Ruffner
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60549 (2013)
Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and
Externí odkaz:
https://doaj.org/article/1a29280cc2c64abea83155ffa4d309fa
Autor:
Victoriano Tamez, Brant Firestone, Michelle Fodor, Martin Sendzik, Michael G. Acker, Stan Spence, Matthew J. LaMarche, Mitsunori Kato, Chen Liu, Christopher Towler, Ping Wang, Ho Man Chan, Eric McNeill, Shumei Liu, Morvarid Mohseni, Sarah Williams, Zhouliang Chen, Gang Liu, Bing Yu, Robert Koenig, Huaixiang Hao, Ying-Nan Chen, Murphy Hentemann, Ritesh Bhanudasji Tichkule, Hongyun Wang, Jorge Garcia Fortanet, Laura R. LaBonte, Jeffrey T. Bagdanoff, Travis Stams, Patrick James Sarver
Publikováno v:
Journal of Medicinal Chemistry. 62:1793-1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fu
Autor:
Giordano Caponigro, Emmanuelle di Tomaso, William R. Sellers, Iain Mulford, Sunkyu Kim, Alice Loo, Scott Delach, Michael G. Acker, Maria Pinzon-Ortiz, Barbara Schacher Engstler, Ralph Tiedt, Christopher Thomas Brain, Thomas Horn, Rajiv Chopra, Kristy Haas, Steven Kovats, Alexander Cao
Publikováno v:
Oncotarget
Inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) is associated with robust antitumor activity. Ribociclib (LEE011) is an orally bioavailable CDK4/6 inhibitor that is approved for the treatment of hormone receptor-positive, human epidermal grow
Autor:
Anamarija Pfeiffer, Steven P. Gygi, Michael G. Acker, Jonathan R. LaRochelle, Stephen C. Blacklow, Kartik Subramanian, Lily A. Chylek, Vidyasiri Vemulapalli, Alison R. Erickson, Ruili Cao, Kimberley Stegmaier, Khal-Hentz Gabriel, Matthew J. LaMarche, Peter K. Sorger, Morvarid Mohseni
Publikováno v:
Vemulapalli, V, Chylek, L A, Erickson, A, Pfeiffer, A, Gabriel, K H, Larochelle, J, Subramanian, K, Cao, R, Stegmaier, K, Mohseni, M, Lamarche, M J, Acker, M G, Sorger, P K, Gygi, S P & Blacklow, S C 2021, ' Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of shp2-dependent signaling ', eLife, vol. 10, e64251 . https://doi.org/10.7554/eLife.64251
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Autor:
Lily A. Chylek, Khal-Hentz Gabriel, Kartik Subramanian, Kimberley Stegmaier, Vidyasiri Vemulapalli, Matthew J. LaMarche, Jonathan R. LaRochelle, Michael G. Acker, Peter K. Sorger, Stephen C. Blacklow, Alison R. Erickson, Steven P. Gygi, Ruili Cao, Anamarija Pfeiffer, Morvarid Mohseni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df87f7af9d99845bffe30ee9bd0ee0b0
https://doi.org/10.7554/elife.64251.sa2
https://doi.org/10.7554/elife.64251.sa2
Autor:
Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
Publikováno v:
Journal of medicinal chemistry. 63(22)
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role in the programed cell death pathway (PD-1/PD-L1). As an
Autor:
Sara J. Buhrlage, Jonathan R. LaRochelle, Morvarid Mohseni, Vidyasiri Vemulapalli, Xiaoxi Liu, Matthew J. LaMarche, Jana M. Ellegast, Michael G. Acker, Michelle Fodor, Kimberly Stegmaier, Stephen C. Blacklow, Travis Stams
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6479-6485
The PTPN11 oncogene encodes the cytoplasmic protein tyrosine phosphatase SHP2, which, through its role in multiple signaling pathways, promotes the progression of hematological malignancies and other cancers. Here, we employ high-throughput screening
Autor:
Jacob R. Haling, David A. Ruddy, Giordano Caponigro, Jodi Meltzer, Scott Delach, Daniel P. Rakiec, Marissa Balak, Michael G. Acker, Joshua M. Korn, Ping Wang, Kelli-Ann Monaco, Caroline Emery, Alyson K. Freeman
Publikováno v:
Molecular Cancer Research. 15:1431-1444
Alterations in MEK1/2 occur in cancers, both in the treatment-naïve state and following targeted therapies, most notably BRAF and MEK inhibitors in BRAF-V600E–mutant melanoma and colorectal cancer. Efforts were undertaken to understand the effects
Autor:
Christopher Towler, Andriana Jouk, Murphy Hentemann, Matthew J. LaMarche, Bing Yu, Jorge Garcia Fortanet, Michelle Fodor, Hongyun Wang, Sarah Williams, Morvarid Mohseni, Shumei Liu, Huaixiang Hao, Ritesh Bhanudasji Tichkule, Ying-Nan Chen, Chen Liu, Ping Wang, Patrick James Sarver, Stan Spence, Laura R. LaBonte, Jeffrey T. Bagdanoff, Brant Firestone, Michael Shultz, Martin Sendzik, Eric McNeill, Zhouliang Chen, Gang Liu, Victoriano Tamez, Robert Koenig, Michael G. Acker, Ho Man Chan, Travis Stams, Mitsunori Kato
Publikováno v:
Journal of medicinal chemistry. 62(7)