Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19

Autor: Nathalie A. Lengacher, Julianna J. Tomlinson, Ann-Kristin Jochum, Jonas Franz, Omar Hasan Ali, Lukas Flatz, Wolfram Jochum, Josef Penninger, aSCENT-PD Investigators, Christine Stadelmann, John M. Woulfe, Michael G. Schlossmacher

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)

Abstract The majority of patients with Parkinson disease (PD) experience a loss in their sense of smell and accumulate insoluble α-synuclein aggregates in their olfactory bulbs (OB). Subjects affected by a SARS-CoV-2-linked illness (COVID-19) also f

Externí odkaz: https://doaj.org/article/55e9314822274d27aa985e4800b41313

Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions

Autor: Alp Ozgun, David J. Lomboni, Amy Aylsworth, Allison Macdonald, William A. Staines, Marzia Martina, Michael G. Schlossmacher, Joseph S. Tauskela, John Woulfe, Fabio Variola

Publikováno v: Materials Today Bio, Vol 25, Iss , Pp 100992- (2024)

Modern in vitro technologies for preclinical research, including organ-on-a-chip, organoids- and assembloid-based systems, have rapidly emerged as pivotal tools for elucidating disease mechanisms and assessing the efficacy of putative therapeutics. I

Externí odkaz: https://doaj.org/article/d2bae2e1d0ce40cf9af33ace061c32c7

Evaluation of the PREDIGT score’s performance in identifying newly diagnosed Parkinson’s patients without motor examination

Autor: Juan Li, Tiago A. Mestre, Brit Mollenhauer, Mark Frasier, Julianna J. Tomlinson, Claudia Trenkwalder, Tim Ramsay, Douglas Manuel, Michael G. Schlossmacher

Publikováno v: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)

Abstract Several recent publications described algorithms to identify subjects with Parkinson’s disease (PD). In creating the “PREDIGT Score”, we previously developed a hypothesis-driven, simple-to-use formula to potentially calculate the incid

Externí odkaz: https://doaj.org/article/3e5f4b52c8c343aca667103a4f90af4c

Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α‐Synuclein

Autor: Poul Henning Jensen, Michael G. Schlossmacher, Leonidas Stefanis

Publikováno v: Jensen, P H, Schlossmacher, M G & Stefanis, L 2023, ' Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α-Synuclein ', Movement disorders : official journal of the Movement Disorder Society, vol. 38, no. 3, pp. 378-384 . https://doi.org/10.1002/mds.29318

Two recent, high-profile manuscripts reported negative results with two parallel approaches of passive immunization targeting α-synuclein in a population of patients with early Parkinson's disease (PD). These phase II studies failed to show a bona f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6de29e0db581cfc074cf3e8a4c7cf5
https://doi.org/10.1002/mds.29318

Defining the Riddle in Order to Solve It

Autor: Tiago F. Outeiro, Roy N. Alcalay, Angelo Antonini, Johannes Attems, Vincenzo Bonifati, Francisco Cardoso, Marie‐Françoise Chesselet, John Hardy, Graziella Madeo, Ian McKeith, Brit Mollenhauer, Darren J. Moore, Olivier Rascol, Michael G. Schlossmacher, Hermona Soreq, Leonidas Stefanis, Joaquim J. Ferreira

Publikováno v: Movement Disorders.

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb22e34137b10dbcc6559f0945efb1a
http://www.scopus.com/inward/record.url?scp=85158107714&partnerID=8YFLogxK