Zobrazeno 1 - 10 of 203 pro vyhledávání: '"Michael G, Klein"'
1
Akademický článek
Antimicrobial Peptides (AMP) in the Cell-Free Culture Media of Xenorhabdus budapestensis and X. szentirmaii Exert Anti-Protist Activity against Eukaryotic Vertebrate Pathogens including Histomonas meleagridis and Leishmania donovani Species
Autor: András Fodor, Claudia Hess, Petra Ganas, Zsófia Boros, János Kiss, László Makrai, Károly Dublecz, László Pál, László Fodor, Anna Sebestyén, Michael G. Klein, Eustachio Tarasco, Manjusha M. Kulkarni, Bradford S. McGwire, Tibor Vellai, Michael Hess
Publikováno v: Antibiotics, Vol 12, Iss 9, p 1462 (2023)
Anti-microbial peptides provide a powerful toolkit for combating multidrug resistance. Combating eukaryotic pathogens is complicated because the intracellular drug targets in the eukaryotic pathogen are frequently homologs of cellular structures of v
Externí odkaz: https://doaj.org/article/cfbfa64ad3e74b419f062d1fee1593d1
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2
Akademický článek
Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study
Autor: Michael G. Klein, Mori J. Krantz, Naheed Fatima, Ashlie Watters, Dayan Colon‐Sanchez, Robert M. Geiger, Robert E. Goldstein, Soroosh Solhjoo, Philip S. Mehler, Thomas P. Flagg, Mark C. Haigney
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022)
Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K+ current (IKr), the principal mechanism of drug‐associated arrhythmia. Congenital
Externí odkaz: https://doaj.org/article/4836ae533faf4cd6a1dc608576af254e
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3
Akademický článek
XENOFOOD—An Autoclaved Feed Supplement Containing Autoclavable Antimicrobial Peptides—Exerts Anticoccidial GI Activity, and Causes Bursa Enlargement, but Has No Detectable Harmful Effects in Broiler Cockerels despite In Vitro Detectable Cytotoxicity on LHM Cells
Autor: András Fodor, Tibor Vellai, Claudia Hess, László Makrai, Károly Dublecz, László Pál, Andor Molnár, Michael G. Klein, Eustachio Tarasco, Sándor Józsa, Petra Ganas, Michael Hess
Publikováno v: Pathogens, Vol 12, Iss 3, p 458 (2023)
Entomopathogenic bacteria are obligate symbionts of entomopathogenic nematode (EPN) species. These bacteria biosynthesize and release non-ribosomal-templated hybrid peptides (NR-AMPs), with strong, and large-spectral antimicrobial potential, capable
Externí odkaz: https://doaj.org/article/1a6b238c4e034155be5479d604b691f0
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4
Akademický článek
Modelling the COVID-19 pandemic in context: an international participatory approach
Autor: Ali Mirzazadeh, Hamid Sharifi, Proochista Ariana, Sunil Pokharel, Siyu Chen, Ricardo Aguas, Sudhir Venkatesan, Lisa White, Nathaniel Hupert, Rima Shretta, Wirichada Pan-Ngum, Olivier Celhay, Ainura Moldokmatova, Fatima Arifi, Keyrellous Adib, Mohammad Nadir Sahak, Caroline Franco, Renato Coutinho, Penny Hancock, Roberto A. Kraenkel, Sompob Saralamba, Nantasit Luangasanatip, Sheetal Prakash Silal, Jared Norman, Rachel Hounsell, Sai Tun, Yu Nandar Aung, A Bakare Emmanuel, Biniam Getachew, Sandra Adele, Semeeh A. Omoleke, Rashid U Zaman, Nicholas Letchford, Daniel M. Parker, Dipti Lata, Shwe Sin Kyaw, Inke N D Lubis, Ivana Alona, John Robert C. Medina, Chris Erwin G. Mercado, Sana Eybpoosh, Ibrahim Mamadu, Manar Marzouk, Nicole Feune de Colombi, Lorena Suárez-Idueta, Francisco Obando, Luzia Freitas, Michael G. Klein, David Scales, Dooronbekova Aizhan, Chynar Zhumalieva, Aida Estebesova, Aibek Mukambetov, Shamil Ibragimov, Aisuluu Kubatova, Phetsavanh Chanthavialy, Amel H. Salim, KC Sarin, Priyanka Shrestha, Sayed Ataullah Saeedzai, Jenny Hsieh, Mick Soukavong, Yuki Yunanda, Handoyo Harsono, Mahnaz Hossain Fariba, Viviana Mabombo, Nicole Advani, Nusrat Jabin, Reshania Naidoo, Parinda Wattanasri, Amen-Patrick Nwosu, Sopuruchukwu Obiesie
Publikováno v: BMJ Global Health, Vol 5, Iss 12 (2020)
The SARS-CoV-2 pandemic has had an unprecedented impact on multiple levels of society. Not only has the pandemic completely overwhelmed some health systems but it has also changed how scientific evidence is shared and increased the pace at which such
Externí odkaz: https://doaj.org/article/2eff4a88992d40f3a47ac8ba5b120e29
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5
Akademický článek
Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional Sources of Non-Ribosomal Templated, Large-Target-Spectral, Thermotolerant-Antimicrobial Peptides (by Both), and Iodinin (by EMC)
Autor: András Fodor, Maxime Gualtieri, Matthias Zeller, Eustachio Tarasco, Michael G. Klein, Andrea M. Fodor, Leroy Haynes, Katalin Lengyel, Steven A. Forst, Ghazala M. Furgani, Levente Karaffa, Tibor Vellai
Publikováno v: Pathogens, Vol 11, Iss 3, p 342 (2022)
Antimicrobial multidrug resistance (MDR) is a global challenge, not only for public health, but also for sustainable agriculture. Antibiotics used in humans should be ruled out for use in veterinary or agricultural settings. Applying antimicrobial pe
Externí odkaz: https://doaj.org/article/a018e4bb9678425db04a9a6a608a0c01
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6
Akademický článek
Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
Autor: Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 6, Pp 1-15 (2018)
Abstract The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent
Externí odkaz: https://doaj.org/article/5f979a579b0246ad90c5cfcded6e406d
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7
Sequencing by avidity enables high accuracy with low reagent consumption
Autor: Sinan Arslan, Francisco J. Garcia, Minghao Guo, Matthew W. Kellinger, Semyon Kruglyak, Jake A. LeVieux, Adeline H. Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B. Byrne, Chiting Chang, Steve X. Chen, Byungrae Cho, Claudia N. Dennler, Vivian T. Dien, Derek Fuller, Ryan Kelley, Omid Khandan, Michael G. Klein, Michael Kim, Bryan R. Lajoie, Bill Lin, Yu Liu, Tyler Lopez, Peter T. Mains, Andrew D. Price, Samantha R. Robertson, Hermes Taylor-Weiner, Ramreddy Tippana, Austin B. Tomaney, Su Zhang, Minna Abtahi, Mark R. Ambroso, Rosita Bajari, Ava M. Bellizzi, Chris B. Benitez, Daniel R. Berard, Lorenzo Berti, Kelly N. Blease, Angela P. Blum, Andrew M. Boddicker, Leo Bondar, Chris Brown, Chris A. Bui, Juan Calleja-Aguirre, Kevin Cappa, Joshua Chan, Victor W. Chang, Katherine Charov, Xiyi Chen, Rodger M. Constandse, Weston Damron, Mariam Dawood, Nicole DeBuono, John D. Dimalanta, Laure Edoli, Keerthana Elango, Nikka Faustino, Chao Feng, Matthew Ferrari, Keith Frankie, Adam Fries, Anne Galloway, Vlad Gavrila, Gregory J. Gemmen, James Ghadiali, Arash Ghorbani, Logan A. Goddard, Adriana Roginski Guetter, Garren L. Hendricks, Jendrik Hentschel, Daniel J. Honigfort, Yun-Ting Hsieh, Yu-Hsien Hwang Fu, Scott K. Im, Chaoyi Jin, Shradha Kabu, Daniel E. Kincade, Shawn Levy, Yu Li, Vincent K. Liang, William H. Light, Jonathan B. Lipsher, Tsung-li Liu, Grace Long, Rui Ma, John M. Mailloux, Kyle A. Mandla, Anyssa R. Martinez, Max Mass, Daniel T. McKean, Michael Meron, Edmund A. Miller, Celyne S. Moh, Rachel K. Moore, Juan Moreno, Jordan M. Neysmith, Cassandra S. Niman, Jesus M. Nunez, Micah T. Ojeda, Sara Espinosa Ortiz, Jenna Owens, Geoffrey Piland, Daniel J. Proctor, Josua B. Purba, Michael Ray, Daisong Rong, Virginia M. Saade, Sanchari Saha, Gustav Santo Tomas, Nicholas Scheidler, Luqmanal H. Sirajudeen, Samantha Snow, Gudrun Stengel, Ryan Stinson, Michael J. Stone, Keoni J. Sundseth, Eileen Thai, Connor J. Thompson, Marco Tjioe, Christy L. Trejo, Greg Trieger, Diane Ni Truong, Ben Tse, Benjamin Voiles, Henry Vuong, Jennifer C. Wong, Chiung-Ting Wu, Hua Yu, Yingxian Yu, Ming Yu, Xi Zhang, Da Zhao, Genhua Zheng, Molly He, Michael Previte
Publikováno v: Nature Biotechnology.
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of stepping along a DNA template and that of identifying each nucleotide within the template. Nucleotide identification uses multivalent nucleotide ligands
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::134ecc28f29d15d85c9ac30057097e39
https://doi.org/10.1038/s41587-023-01750-7
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8
XENOFOOD—An Autoclaved Feed Supplement Containing Autoclavable Antimicrobial Peptides—Exerts Anticoccidial GI Activity, and Causes Bursa Enlargement, but Has No Detectable Harmful Effects in Broiler Cockerels despite In Vitro Detectable Cytotoxicity on LHM Cells
Autor: Hess, András Fodor, Tibor Vellai, Claudia Hess, László Makrai, Károly Dublecz, László Pál, Andor Molnár, Michael G. Klein, Eustachio Tarasco, Sándor Józsa, Petra Ganas, Michael
Publikováno v: Pathogens; Volume 12; Issue 3; Pages: 458
Entomopathogenic bacteria are obligate symbionts of entomopathogenic nematode (EPN) species. These bacteria biosynthesize and release non-ribosomal-templated hybrid peptides (NR-AMPs), with strong, and large-spectral antimicrobial potential, capable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::e74d833d2bc99dc0a6afe5ffa8be108f
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10
Akademický článek
Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review
Autor: András Fodor, Birhan Addisie Abate, Péter Deák, László Fodor, Ervin Gyenge, Michael G. Klein, Zsuzsanna Koncz, Josephat Muvevi, László Ötvös, Gyöngyi Székely, Dávid Vozik, László Makrai
Publikováno v: Pathogens, Vol 9, Iss 7, p 522 (2020)
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fat
Externí odkaz: https://doaj.org/article/6e1421dd69f94a678073310d05df321f
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