Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score

Autor: Johan Hartman, Michael Friis Lippert, Balazs Acs, Stephanie Robertson

Publikováno v: Breast Cancer Research and Treatment

Purpose The proliferation-associated biomarker Ki67 has potential utility in breast cancer, including aiding decisions based on prognosis, but has unacceptable inter- and intralaboratory variability. The aim of this study was to compare the prognosti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297b9f1909e937c70ebe837187c3a0a8
https://doi.org/10.1007/s10549-020-05752-w

Digital image analysis of Ki67 in hot spots is superior to both manual Ki67 and mitotic counts in breast cancer

Autor: Lena Wedlund, Johan Hartman, Stephanie Robertson, Michael Friis Lippert, Mattias Rantalainen, Gustav Stålhammar, Jonas Bergh

Publikováno v: Histopathology. 72:974-989

Aims During pathological examination of breast tumours, proliferative activity is routinely evaluated by a count of mitoses. Adding immunohistochemical stains of Ki67 provides extra prognostic and predictive information. However, the currently used m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ce93c48f53a54fe9d06fd3464f2df1
https://doi.org/10.1111/his.13452

Digital image analysis outperforms manual biomarker assessment in breast cancer

Autor: Ida Mølholm, Jonas Bergh, Mattias Rantalainen, Lorand Kis, Gustaf Rosin, Michael Friis Lippert, Gustav Stålhammar, Nelson Fuentes Martinez, Lars Pedersen, Nicholas P. Tobin, Johan Hartman, Michael Grunkin

Publikováno v: Stålhammar, G, Fuentes Martinez, N, Lippert, M, Tobin, N P, Mølholm, I, Kis, L, Rosin, G, Rantalainen, M, Pedersen, L, Bergh, J, Grunkin, M & Hartman, J 2016, ' Digital image analysis outperforms manual biomarker assessment in breast cancer ', Modern Pathology, vol. 29, no. 4, pp. 318-329 . https://doi.org/10.1038/modpathol.2016.34

In the spectrum of breast cancers, categorization according to the four gene expression-based subtypes 'Luminal A,' 'Luminal B,' 'HER2-enriched,' and 'Basal-like' is the method of choice for prognostic and predictive value. As gene expression assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f2a2ae03a0afa535cf71733a605edd
https://doi.org/10.1038/modpathol.2016.34

Virtual Double Staining: A Digital Approach to Immunohistochemical Quantification of Estrogen Receptor Protein in Breast Carcinoma Specimens

Autor: Nina Lykkegaard Andersen, Michael Friis Lippert, Giedrius Lelkaitis, Anja Høegh Brügmann, Mogens Vyberg, Søren Nielsen

Publikováno v: Andersen, N L, Brügmann, A, Lelkaitis, G, Nielsen, S, Friis Lippert, M & Vyberg, M 2018, ' Virtual Double Staining : A Digital Approach to Immunohistochemical Quantification of Estrogen Receptor Protein in Breast Carcinoma Specimens ', Applied Immunohistochemistry & Molecular Morphology, vol. 26, no. 9, pp. 620-626 . https://doi.org/10.1097/PAI.0000000000000502

Visual assessment of immunohistochemically detected estrogen receptor protein is prone to interobserver and intraobserver variation due to its subjective evaluation. The aim of this study was to validate a new image analysis system based on virtual d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e7ece3e6d34160349f7f7c404d2910
https://pubmed.ncbi.nlm.nih.gov/28248729

Screening of subfertile men for testicular carcinoma in situ by an automated image analysis-based cytological test of the ejaculate

Autor: N E Skakkebaek, E. Rajpert-De Meyts, Gedske Daugaard, N T Foged, H O Mogensen, Kristian Almstrup, Michael Friis Lippert, Niels Jørgensen, J D Hansen, J E Nielsen

Publikováno v: International Journal of Andrology. 34:e21-e31

Testicular cancer (TC) is usually diagnosed after manifestation of an overt tumour. Tumour formation is preceded by a pre-invasive and asymptomatic stage, carcinoma in situ (CIS) testis, except for very rare subtypes. The CIS cells are located within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::758f3144f75625848a44b00839fd2cdc
https://doi.org/10.1111/j.1365-2605.2011.01192.x