Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Michael Fricker"'
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30612- (2024)
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and healthcare burden worldwide. The progression of COPD is a combination of genetic predisposition and environmental factors, primarily cigarette smoking, and the underlying
Externí odkaz:
https://doaj.org/article/5877f14ef2414acaa551135ee17b95ea
Autor:
Natalie M. Niessen, Peter G. Gibson, Jodie L. Simpson, Hayley A. Scott, Katherine J. Baines, Michael Fricker
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Background Dysregulation of tumour necrosis factor-α (TNF-α) signalling is implicated in neutrophilic asthma. TNF-α signalling involves membrane-bound and soluble ligand (TNF-α) and receptors (TNFRs); however, little is known about how these prot
Externí odkaz:
https://doaj.org/article/34d847559d3d48e88db97493644c2095
Autor:
Melanie Erriah, Kavita Pabreja, Michael Fricker, Katherine J. Baines, Louise E. Donnelly, Johan Bylund, Anna Karlsson, Jodie L. Simpson
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously been shown to improve the ability of airway macrophages to ingest apoptot
Externí odkaz:
https://doaj.org/article/05217bddf8b543ee8ce89e98677e15a5
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238740 (2020)
Sensitization to Hymenoptera venom in patients without a history of systemic allergic reactions to Hymenoptera stings is frequently found and can be due to the presence of specific IgE to cross-reactive carbohydrate determinants (CCD). This study inv
Externí odkaz:
https://doaj.org/article/3beb721b75cf47d8b08427407752a79a
Autor:
Nazanin Zounemat Kermani, Lisa Wood, Carlos Riveros, Jodie L. Simpson, Stephany Sánchez-Ovando, Michael Fricker, Katherine J. Baines, Peter G. Gibson, Kian Fan Chung, Hayley A. Scott, Ling Qin, Peter A. B. Wark
Publikováno v:
Allergy. 77:1204-1215
BACKGROUND Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long-lived immune cells that exert important homeostatic and inflammatory f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8057f707242c84f521ccdd3a323a32f3
https://doi.org/10.1111/all.15087
https://doi.org/10.1111/all.15087
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Natasha A Winter,1â 3 Peter G Gibson,1â 5 Vanessa M McDonald,1,2,4,6 Michael Fricker1â 4 1National Health and Medical Research Council Centre for Research Excellence in Severe Asthma, Newcastle, NSW, Australia; 2The Priority Research C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992688a0cf9d8196b6ea420a2886b00e
https://doi.org/10.2147/copd.s305380
https://doi.org/10.2147/copd.s305380
Autor:
Peter G. Gibson, Jodie L. Simpson, Vanessa M. McDonald, Peter A. B. Wark, Michael Fricker, Katherine J. Baines, Natasha A Winter
Publikováno v:
Allergy. 76:2079-2089
BACKGROUND Airway and systemic eosinophilia are important treatable traits in both severe asthma and COPD. The molecular basis of eosinophilia in COPD is poorly understood but could involve type 2 cytokines (IL5, IL13) and prostaglandin D2 (PGD2 ). M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22528931907cf74d110f0d523fb9792c
https://doi.org/10.1111/all.14741
https://doi.org/10.1111/all.14741
Autor:
Jodie L. Simpson, Natalie M. Niessen, Hayley A. Scott, Ling Qin, Peter G. Gibson, Michael Fricker, Katherine J. Baines
Publikováno v:
Clinical & Experimental Allergy. 51:305-317
BACKGROUND Monocytes and macrophages are critical innate immune cells of the airways. Despite their differing functions, few clinical studies discriminate between them and little is known about their regulation in asthma. OBJECTIVE We aimed to distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ef34ca7af58bdb1e1a15e861dc875
https://doi.org/10.1111/cea.13811
https://doi.org/10.1111/cea.13811
Autor:
Juan-Juan Fu, Netsanet A. Negewo, Vanessa M. McDonald, Peter G. Gibson, Peter A. B. Wark, Jodie L. Simpson, Michael Fricker, Katherine J. Baines
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 15:1577-1590
Background The 6 gene expression signature (6GS) predicts inflammatory phenotype, exacerbation risk, and corticosteroid responsiveness in asthma. In COPD, patterns of airway inflammation are similar, suggesting the 6GS may be useful. This study deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b52d9d606560089cb1639fe06dddf3d
https://doi.org/10.2147/copd.s245519
https://doi.org/10.2147/copd.s245519
Autor:
Vanessa M. McDonald, Natalie M. Niessen, Hayley A. Scott, Jodie L. Simpson, Katherine J. Baines, Michael Fricker, Peter G. Gibson, Ling Qin
Publikováno v:
Clinical & Experimental Allergy. 50:696-707
Background Mast cells (MCs) are innate immune cells that regulate atopic and non-atopic inflammation in the airways. MCs play a critical role in the pathogenesis of asthma, yet their relationship to airway and systemic inflammation and clinical chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fc0f5a5031bec7573c28db56909974
https://doi.org/10.1111/cea.13609
https://doi.org/10.1111/cea.13609