Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Michael Frech"'
Autor:
Vugar Azizov, Michel Hübner, Michael Frech, Jörg Hofmann, Marketa Kubankova, Dennis Lapuente, Matthias Tenbusch, Jochen Guck, Georg Schett, Mario M. Zaiss
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107230- (2023)
Summary: Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages the liver, heart, and brain. Alcohol also has strong immunoregulatory properties. Here, we report how alcohol impairs T cell function via ace
Externí odkaz:
https://doaj.org/article/4f38ace1511c4f95970755bb2e6a147e
Autor:
Kerstin Dürholz, Eva Schmid, Michael Frech, Vugar Azizov, Nadine Otterbein, Sébastien Lucas, Manfred Rauh, Georg Schett, Heiko Bruns, Mario M. Zaiss
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone mar
Externí odkaz:
https://doaj.org/article/f698914e2b054ddaa852268ec18addb1
Autor:
Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Cañete, Francesco Ciccia, Georg Schett, Mario M. Zaiss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, an
Externí odkaz:
https://doaj.org/article/85f50113935441358e580e8e7a413f86
Autor:
Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, Georg Schett, Mario M. Zaiss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Moderate consumption of alcohol is associated with protection from some autoimmune diseases. Here the authors show that ethanol and its metabolite acetate can protect mice from collagen-induced arthritis and provide evidence that the mechanism of thi
Externí odkaz:
https://doaj.org/article/eeef82bd54c54d9ebcc3a76561c3042f
Autor:
Michael Frech, Yasunori Omata, Angelika Schmalzl, Stefan Wirtz, Leila Taher, Georg Schett, Mario M. Zaiss, Kerstin Sarter
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate lymphoid cells (ILC) not only are responsible for shaping the innate immune response but also actively modulate T cell responses. However, the molecular processes regulating ILC-T cell interaction are not yet completely understood. The protein
Externí odkaz:
https://doaj.org/article/ea3248d47e2c47949c48613beac0cd98
Autor:
Michael Frech, Gregor Schuster, Fabian T. Andes, Georg Schett, Mario M. Zaiss, Kerstin Sarter
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Butyrophilins, which are members of the extended B7 family of immunoregulators structurally related to the B7 family, have diverse functions on immune cells as co-stimulatory and co-inhibitory molecules. Despite recent advances in the understanding o
Externí odkaz:
https://doaj.org/article/51352d8a5e4749bba5ff32647ec64401
Publikováno v:
MethodsX, Vol 7, Iss , Pp 101054- (2020)
Group 2 innate lymphoid cells (ILC2s) are a recently recognized subset of innate lymphocytes with crucial role in mucosal immunity and tissue homeostasis. Over the past decade, substantial advances in our understanding of ILC2 biology have establishe
Externí odkaz:
https://doaj.org/article/fbb0f95a59e1438d81e059714c7457b1
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1104 (2022)
While type 2 immunity has traditionally been associated with the control of parasitic infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts regulatory functions on inflammatory diseases such as arthritis, and als
Externí odkaz:
https://doaj.org/article/729702fa6c024f9c9c83d4adfac93931
Autor:
Yasunori Omata, Michael Frech, Tatjana Primbs, Sébastien Lucas, Darja Andreev, Carina Scholtysek, Kerstin Sarter, Markus Kindermann, Nataliya Yeremenko, Dominique L. Baeten, Nico Andreas, Thomas Kamradt, Aline Bozec, Andreas Ramming, Gerhard Krönke, Stefan Wirtz, Georg Schett, Mario M. Zaiss
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 169-180 (2018)
Summary: Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s wer
Externí odkaz:
https://doaj.org/article/887aecb0527247c7819b597695f65869
Autor:
Julian Häger, Holger Bang, Melanie Hagen, Michael Frech, Pascal Träger, Maria V. Sokolova, Ulrike Steffen, Koray Tascilar, Kerstin Sarter, Georg Schett, Jürgen Rech, Mario M. Zaiss
Publikováno v:
Nutrients, Vol 11, Iss 10, p 2392 (2019)
Short-chain fatty acids are microbial metabolites that have been shown to be key regulators of the gut−joint axis in animal models. In humans, microbial dysbiosis was observed in rheumatoid arthritis (RA) patients as well as in those at-risk to dev
Externí odkaz:
https://doaj.org/article/5a39daded64b432a86898565f82b23ce