Výsledky vyhledávání - "Michael Francis Walsh"

Early age of onset and broad cancer spectrum persist in MSH6 and PMS2-associated Lynch syndrome

Publikováno v: Journal of Clinical Oncology. 39:10516-10516

10516 Background: Recently updated NCCN guidelines for management of germline MSH6 and PMS2 pathogenic/likely pathogenic (P/LP) variant carriers suggest a more modest phenotype with later onset colorectal cancer (CRC) and limited extra-colonic cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1050a6b2c8b76839aa3cc55029161f
https://doi.org/10.1200/jco.2021.39.15_suppl.10516

Zobrazit plný text záznamu

Disparities in pan-cancer patients undergoing germline cancer risk assessment by self-reported race/ethnicity and ancestry

Autor: Alicia Latham, Anna Maio, Margaret Sheehan, Ying L Liu, Carol Aghajanian, Maria I. Carlo, Luis A. Diaz, Kenneth Offit, Magan Trottier, Megan Harlan Fleischut, Jada G. Hamilton, Diana Mandelker, Carol L. Brown, Mark E. Robson, Prince Rainier Tejada, Yelena Kemel, Zsofia K. Stadler, Erin E. Salo-Mullen, Michael Francis Walsh

Publikováno v: Journal of Clinical Oncology. 39:10508-10508

10508 Background: Disparities in access to germline testing for cancer patients (pts) have been demonstrated; however, disparities in post-testing care are unknown. We sought to evaluate germline findings and subsequent genetic counseling/care in can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2941abebcea36cc2e1c1d76335b03e9f
https://doi.org/10.1200/jco.2021.39.15_suppl.10508

Zobrazit plný text záznamu

Uptake of oophorectomy in women with findings on multigene panel testing: Results from the Prospective Registry of Multiplex Testing (PROMPT)

Autor: Judy Garber, Mark E. Robson, Vanessa Marcell, Michael Francis Walsh, Heather Symecko, Jada G. Hamilton, Susan M. Domchek, Fergus J. Couch, Jamie Brower, Kenneth Offit

Publikováno v: Journal of Clinical Oncology. 38:1508-1508

1508 Background: With the expansion of multigene panel testing for cancer susceptibility, increasing numbers of patients are identified with pathogenic/likely pathogenic variants (P/LP V) in genes which do not have a clearly actionable increased risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32e65ec2e80dc8a406eecb0fd0361e66
https://doi.org/10.1200/jco.2020.38.15_suppl.1508

Zobrazit plný text záznamu

Characterization of patients with multiple primary tumors

Publikováno v: Journal of Clinical Oncology. 38:1502-1502

1502 Background: 17% of patients (pts) with a cancer diagnosis in the U.S. have a prior malignancy. We sought to characterize pts with multiple (≥2) primary cancers (MPC) & identify potential drivers of cancer risk to guide management. Methods: Pts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79403fb49e8282da82989eca8fa7400b
https://doi.org/10.1200/jco.2020.38.15_suppl.1502

Zobrazit plný text záznamu

Prospective agnostic germline testing in pediatric cancer patients

Autor: Yelena Kemel, Ozge Birsoy, Karen Cadoo, Audrey Mauguen, Neerav Shukla, Elise Fiala, Stephen S. Roberts, Andrew L. Kung, Mark E. Robson, Ahmet Zehir, Anna Maio, Maria I. Carlo, Alicia Latham, Zsofia K. Stadler, Kenneth Offit, Michael Francis Walsh, Jennifer Kennedy, Diana Mandelker, Nancy Bouvier

Publikováno v: Journal of Clinical Oncology. 38:1589-1589

1589 Background: We report our large cohort of pediatric cancer patients undergoing prospective agnostic germline sequencing. Our dataset is a significant addition to the 1,573 children reported to date who have undergone agnostic germline sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccc35a700142f0b6956081e78a087fa7
https://doi.org/10.1200/jco.2020.38.15_suppl.1589

Zobrazit plný text záznamu

Prevalence and clinical characterization of MMR-D/MSI extra-colonic cancers among germline PMS2 mutation carriers

Publikováno v: Journal of Clinical Oncology. 38:1527-1527

1527 Background: PMS2-associated Lynch syndrome (LS) may have a more modest phenotype than that associated with other mismatch repair (MMR) genes ( MLH1, MSH2, MSH6, EPCAM). Recent studies suggest limited extra-colonic cancers, and modified risk-redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d508fe31693ab68df4327a48876beba
https://doi.org/10.1200/jco.2020.38.15_suppl.1527

Zobrazit plný text záznamu

Targeted therapy based on germline analysis of tumor-normal sequencing (MSK-IMPACT) in a pan-cancer population

Autor: Michael F. Berger, Yelena Kemel, Michael Francis Walsh, Maria I. Carlo, Karen Cadoo, Zsofia K. Stadler, Diana Mandelker, Ozge Birsoy, Kenneth Offit, Anna Maio, Mark E. Robson, Erin E. Salo-Mullen, David B. Solit, Alicia Latham, Margaret Sheehan, Alexander Drilon, Luis A. Diaz

Publikováno v: Journal of Clinical Oncology. 38:1500-1500

1500 Background: Tumor mutational profiling for identification of somatic alterations for targeted treatment is increasingly being performed in advanced cancer patients (pts). We sought to assess the clinical utility of germline mutation profiling fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a041a0f749c241e85a2c4b0f098ecb54
https://doi.org/10.1200/jco.2020.38.15_suppl.1500

Zobrazit plný text záznamu

Towards automation of germline variant curation in clinical cancer genetics

Autor: Yelena Kemel, Diana Mandelker, Mark E. Robson, Karen Cadoo, Michael Francis Walsh, Steven M. Lipkin, Zarina Shameer, Liying Zhang, Vignesh Ravichandran, Kenneth Offit, Zsofia K. Stadler, Vijai Joseph

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics

Cancer care professionals are confronted with interpreting results from multiplexed gene sequencing of patients at hereditary risk for cancer. Assessments for variant classification now require orthogonal data searches, requiring aggregation of multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a4359e4709d3e26a66efe858d6e992
https://doi.org/10.1101/295865

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání