Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Michael Flannigan"'
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Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy
Autor: Sandie W. Martin, Andrew J. Scally, Saurajyoti Basu, Jill M. Seargent, G. Michael Flannigan, Tariq Shah, R. Puri, John E. Brown, Roger M. Phillips, Jason H. Gill, Brian Naylor, Paul M. Loadman
Publikováno v: International Journal of Cancer. 109:703-709
A central theme within the concept of enzyme-directed bioreductive drug development is the potential to predict tumour response based on the profiling of enzymes involved in the bioreductive activation process. Mitomycin C (MMC) is the prototypical b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481cefb91a49746c432093868a982c02
https://doi.org/10.1002/ijc.20005
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NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C
Autor: Saurajyoti, Basu, John E, Brown, G Michael, Flannigan, Jason H, Gill, Paul M, Loadman, Sandie W, Martin, Brian, Naylor, Rajiv, Puri, Andrew J, Scally, Jill M, Seargent, Tariq, Shah, Roger M, Phillips
Publikováno v: International journal of oncology. 25(4)
NAD(P)H:Quinone oxidoreductase-1 (NQO1) has been implicated in the bioreductive activation of the clinically active anticancer drug Mitomycin C (MMC) and a polymorphic variant of NQO1 which lacks functional enzyme activity (NQO1*2) has been linked wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f267006a4daef5311e091794f00ed02b
https://pubmed.ncbi.nlm.nih.gov/15375541
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Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C↷T and 465C↷T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP
Autor: Paul M. Loadman, Roger M. Phillips, John E. Brown, Saurajyoti Basu, R. Puri, Brian Naylor, Tariq Shah, Sandie W. Martin, G. Michael Flannigan
Publikováno v: International Journal of Oncology.
NQO1 is a cytosolic flavoprotein that plays a dual role in the detoxification of potentially carcinogenic compounds and the bioreductive activation of quinone based anticancer drugs. Two polymorphic variants of NQO1 exist (NQO1*2 and NQO1*3) which ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ac8cbb5e17498c29c468800a0e7930
https://doi.org/10.3892/ijo.24.4.1005
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Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C--T and 465C--T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP
Autor: Roger M, Phillips, Saurajyoti, Basu, John E, Brown, G Michael, Flannigan, Paul M, Loadman, Sandie W, Martin, Brian, Naylor, Rajiv, Puri, Tariq, Shah
Publikováno v: International journal of oncology. 24(4)
NQO1 is a cytosolic flavoprotein that plays a dual role in the detoxification of potentially carcinogenic compounds and the bioreductive activation of quinone based anticancer drugs. Two polymorphic variants of NQO1 exist (NQO1*2 and NQO1*3) which ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5d11b4f4cf0b6b1191b526e287d8d40
https://pubmed.ncbi.nlm.nih.gov/15010841
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