Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael Fichtner"'
Autor:
Ian S. Reynolds, Valentina Thomas, Emer O’Connell, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen H. M. Prehn, John P. Burke, Simon J. Furney
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/518cc9f3e442435ebcdf4de825574ae9
Autor:
Ian S. Reynolds, Valentina Thomas, Emer O’Connell, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen H. M. Prehn, John P. Burke, Simon J. Furney
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
IntroductionMucinous adenocarcinoma of the rectum is an infrequently encountered histological subtype that is associated with an impaired response to chemoradiotherapy and a worse overall prognosis. A genomic profile analysis of mucinous rectal tumor
Externí odkaz:
https://doaj.org/article/513b3d6311d241e6806a353b4fb6d6ee
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Chronic pro-inflammatory signaling propagates damage to neural tissue and affects the rate of disease progression. Increased activation of Toll-like receptors (TLRs), master regulators of the innate immune response, is implicated
Externí odkaz:
https://doaj.org/article/7fe600bce9204c8893a231dc64e51834
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases. Therefore, despite recent advances in the treatment of this disease, it is still considered
Externí odkaz:
https://doaj.org/article/85b97cbbe5854968be63637e2371ac96
Autor:
Anna Matveeva, Michael Fichtner, Katherine McAllister, Christopher McCann, Marc Sturrock, Daniel B Longley, Jochen H M Prehn
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007374 (2019)
Ligand binding to death receptors activates apoptosis in cancer cells. Stimulation of death receptors results in the formation of intracellular multiprotein platforms that either activate the apoptotic initiator Caspase-8 to trigger cell death, or si
Externí odkaz:
https://doaj.org/article/5d6098cfa19c4c0da6f939d03bc61d75
Autor:
Michael Fichtner, Elmar Spies, Henning Seismann, Kristoffer Riecken, Niklas Engels, Barbara Gösch, Judith Dierlamm, Helwe Gerull, Peter Nollau, Wolfram Klapper, Martin Dreyling, Mascha Binder, Martin Trepel
Publikováno v:
Haematologica, Vol 101, Iss 9 (2016)
Externí odkaz:
https://doaj.org/article/98bb599b510c423da049b62f72f49970
Autor:
Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, Jochen H.M Prehn
Publikováno v:
Journal of Neuro-Oncology.
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differenc
Autor:
Tamas Sessler, Sandra Van Schaeybroeck, Jochen H M Prehn, Christopher McCann, Katherine McAllister, Anna Matveeva, Daniel B. Longley, Michael Fichtner, Markus Rehm, Steven Carberry
Publikováno v:
McCann, C, Matveeva, A, McAllister, K, Van Schaeybroeck, S, Sessler, T, Fichtner, M, Carberry, S, Rehm, M, Prehn, J H M & Longley, D B 2021, ' Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer ', The FEBS Journal, vol. 288, no. 18, pp. 5374-5388 . https://doi.org/10.1111/febs.15801
Resistance to chemotherapy-induced cell death is a major barrier to effective treatment of solid tumours such as colorectal cancer, CRC. Herein, we present a study aimed at developing a proteomics-based predictor of response to standard-of-care (SoC)
Autor:
John P. Burke, Ian S Reynolds, Simon J Furney, Emer O'Connell, Elaine W. Kay, Deborah A. McNamara, Jochen H. M. Prehn, Michael Fichtner
Publikováno v:
The Pharmacogenomics Journal. 20:524-532
Mucinous colorectal cancer is a unique histological subtype that is known to respond poorly to cytotoxic chemotherapy and radiotherapy. There are a number of genes known to be associated with resistance to 5-fluorouracil (5-FU), oxaliplatin, and irin
Autor:
Simon J Furney, John P. Burke, Michael Fichtner, Elaine W. Kay, Jochen H. M. Prehn, Ian S Reynolds, Emer O'Connell, Deborah A. McNamara
Publikováno v:
Journal of Surgical Oncology. 120:1427-1435
Background and objectives Mucinous adenocarcinoma is a distinct subtype of colorectal cancer (CRC) with a worse prognosis when compared with non-mucinous adenocarcinoma. The aim of this study was to compare somatic mutations and copy number alteratio