Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael Fazio"'
Autor:
Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissring
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193101 (2018)
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administer
Externí odkaz:
https://doaj.org/article/c9bacd82d9a24f8b81a04be777941d36
Publikováno v:
Nucleic Acid Therapeutics. 31:126-144
Phosphorothioate antisense oligonucleotides (PS-ASOs) interact with proteins and can localize to or induce the formation of a variety of subcellular PS-ASO-protein or PS-ASO-ribonucleoprotein aggregates. In this study, we show that these different ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3abafda90faf50ba6615cca09f83ad8
https://doi.org/10.1089/nat.2020.0923
https://doi.org/10.1089/nat.2020.0923
Autor:
Brendon E. Cook, Jonathan Archbold, Khaled Nasr, Sara Girmay, Stanley I. Goldstein, Pei Li, Sivaraman Dandapani, Nathan E. Genung, Sac-Pham Tang, Stuart McClusky, Christophe Plisson, Megan E. Afetian, Chrissa A. Dwyer, Michael Fazio, William J. Drury, Frank Rigo, Laurent Martarello, Maciej Kaliszczak
Publikováno v:
Molecular imaging and biology. 24(6)
The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into the intrathecal space in order to bypass the blood-brain barrier. Despite th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e72f918165f8a07d9d8a09a98a8da8
https://pubmed.ncbi.nlm.nih.gov/35655109
https://pubmed.ncbi.nlm.nih.gov/35655109
Autor:
Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Kajari Bera, Chi Zhang, Darold R. Spillman, Marina Marjanovic, Michael Fazio, Punit Seth, Kendall S. Frazier, Steve R. Hood, Stephen A. Boppart
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue VI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c5fb401c5603cd53018e4745dbeb46
https://doi.org/10.1117/12.2608740
https://doi.org/10.1117/12.2608740
Autor:
Marina Marjanovic, Derek Shi, Aneesh Alex, Stephen A. Boppart, Michael Fazio, Prabuddha Mukherjee, Edita Aksamitiene, Punit P. Seth, Steve R. Hood, Kendal Frazier, Darold R. Spillman
Publikováno v:
Advanced Chemical Microscopy for Life Science and Translational Medicine 2021.
Antisense oligonucleotides (ASOs) are single stranded negatively charged molecules which downregulate the translation of specific target messenger RNA (mRNA). Chemically modified ASOs with phosphorothioate (PS) linkages have been extensively studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e8ec5c044872ebcdee0dd0a8ef0760
https://doi.org/10.1117/12.2578061
https://doi.org/10.1117/12.2578061
Autor:
Punit P. Seth, Steve R. Hood, Prabuddha Mukherjee, Darold R. Spillman, Stephen A. Boppart, Marina Marjanovic, Aneesh Alex, Edita Aksamitiene, Michael Fazio, Kendal Frazier, Derek Shi
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue V.
Antisense oligonucleotides (ASOs), a novel paradigm in modern therapeutics, modulate cellular gene expression by binding to complementary RNA sequences. Triantennary N-acetyl galactosamine (GN)-conjugated ASOs show greatly improved potency via Asialo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0f51428d436b8656a089014ff5666c
https://doi.org/10.1117/12.2578037
https://doi.org/10.1117/12.2578037
Publikováno v:
BMJ Case Rep
A 29-year-old male paratrooper presented to multiple emergency departments (EDs) and his primary provider multiple times over sequential days. Each time, the patient received the same diagnosis of acute on chronic back pain. The patient was treated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa439bfa82b58360659b83e5105b710
https://europepmc.org/articles/PMC7805351/
https://europepmc.org/articles/PMC7805351/
Autor:
Rachael Peralta, Punit P. Seth, Nitin Nitin, Shuling Guo, Laurel A. Beckett, Michael Oestergaard, Noriko Satake, Michael Fazio, Yueju Li, Connie P.M. Duong, Sakiko Yoshida, Cathy Chen
Publikováno v:
Nanomedicine
Neuroblastoma (NB) is the most common extracranial solid tumor in children. The outcomes for aggressive forms of NB remain poor. The aim of this study was to develop a new molecular-targeted therapy for NB using an antisense oligonucleotide (ASO) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10a3ac4c63f79b6149e5a5df755d1d7
https://escholarship.org/uc/item/07g836nr
https://escholarship.org/uc/item/07g836nr
Autor:
John D. Morgan, Michael Fazio, Courtney Cook, Peter Memiah, Kelechi Ibe-Lamberts, Daudet Ilunga Tshiswaka
Publikováno v:
Journal of Public Health. 27:435-442
The southeast of the United States (USA) is a high stroke prevalence area otherwise known as the “Stroke Belt” in order to characterize the increased stroke morbidity and mortality rates found there. The purpose of this study was to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d1b822b90a5757ec64313a44335f7c6
https://doi.org/10.1007/s10389-018-0974-9
https://doi.org/10.1007/s10389-018-0974-9
Autor:
Kim Nguyen, Ali Mortazavi, Gabriela Balderrama, Robert C. Spitale, Chao Feng, Michael Fazio, Mahima B. Aggarwal
Publikováno v:
ACS chemical biology, vol 13, iss 6
The cellular RNA pool in animals arises from two separate genomes stored in the nucleus and multiple mitochondria. Chemical methods to track nascent RNA synthesis are unable to distinguish between these two with stringency. Herein, we report that spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e132648069cf1cd7d4d2b78443bbe6d1
https://doi.org/10.1021/acschembio.8b00262
https://doi.org/10.1021/acschembio.8b00262