Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Michael Faller"'
Autor:
Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, Abigail E. Case, Wei Ni, Swati Garg, Martin Sattler, Abdel Kareem Azab, Jennifer Sun, Barbara Muz, Dana Sanchez, Anthia Toure, Richard M. Stone, Ilene Galinsky, Eric Winer, Scott Gleim, Sofia Gkountela, Alexia Kedves, Edmund Harrington, Tinya Abrams, Thomas Zoller, Andrea Vaupel, Paul Manley, Michael Faller, BoYee Chung, Xin Chen, Philipp Busenhart, Christine Stephan, Keith Calkins, Debora Bonenfant, Claudio R. Thoma, William Forrester, James D. Griffin
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-10 (2022)
Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule
Externí odkaz:
https://doaj.org/article/3c275c0fed054a4ca5adaa6cd08da2ce
Autor:
Claudia Betschart, Michael Faller, Florence Zink, René Hemmig, Jutta Blank, Eric Vangrevelinghe, Marjorie Bourrel, Ralf Glatthar, Dirk Behnke, Kerstin Barker, Andreas Heizmann, Daniela Angst, Pierre Nimsgern, Sébastien Jacquier, Tobias Junt, Géraldine Zipfel, Giulia Ruzzante, Pius Loetscher, Sarah Limonta, Stuart Hawtin, Cedric Bernard Andre, Thomas Boulay, Roland Feifel, Thomas Knoepfel
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. Here we report on the efficient structure-based optimization of the inhibition of TLR8, starting from a co-crystal stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fee8bacdcd6ab213f658c3a1348d56
https://doi.org/10.1021/acsmedchemlett.1c00696
https://doi.org/10.1021/acsmedchemlett.1c00696
Autor:
Ernst Freund, Dan Huynh, Richard A. Lewis, Eric J. Ma, Markus Stoeckli, Elke Koch, Holger Schlingensiepen, Markus Vogel, Mathieu Ligibel, Radka Snajdrova, Charles Moore, Elina Maria Siirola, Luca Siegrist, Caroline Bouquet, Michael Faller, Edward J. Oakeley, Geoffrey Cutler, Anne-Christine Acker, Fabian K. Eggimann, Arkadij Kummer
Publikováno v:
ACS Catalysis. 11:12433-12445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2831b58d651887d74d5b7574c201a92
https://doi.org/10.1021/acscatal.1c02786
https://doi.org/10.1021/acscatal.1c02786
Autor:
Jonathan A. Deane, Stuart Hawtin, Roland Feifel, Pius Loetscher, Sarah Limonta, Tobias Junt, Ralf Glatthar, Michellys Pierre-Yves, Marjorie Bourrel, Thomas Knoepfel, Cedric Bernard Andre, Thomas Boulay, Pierre Nimsgern, Sebastien Jacquier, Eric Vangrevelinghe, Michael Faller, Claudia Betschart, Jutta Blank, Phillip B. Alper, Geraldine Collignon Zipfel, Dirk Behnke
Publikováno v:
Journal of Medicinal Chemistry. 63:8276-8295
Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a6d30a18c77cefd130b9738cd75108
https://doi.org/10.1021/acs.jmedchem.0c00130
https://doi.org/10.1021/acs.jmedchem.0c00130
Autor:
Dimitry Wintermantel, Maria-Helena Pereira-Peixoto, Nadja Warth, Kristin Melcher, Michael Faller, Joachim Feurer, Matthew J. Allan, Robin Dean, Giovanni Tamburini, Anina C. Knauer, Janine Melanie Schwarz, Matthias Albrecht, Alexandra-Maria Klein
Publikováno v:
Science of The Total Environment
Bees are exposed to various stressors, including pesticides and lack of flowering resources. Despite potential interactions between these stressors, the impacts of pesticides on bees are generally assumed to be consistent across bee-attractive crops,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9010550d546f6a512e42136df997ed13
https://pubmed.ncbi.nlm.nih.gov/35276144
https://pubmed.ncbi.nlm.nih.gov/35276144
Autor:
Mark Freeman, Victoria Head, Binesh Shrestha, Michael Faller, Elizabeth Hardaker, Mark R Dowling, Rene Hemmig, Lucy Elphick, Johan C. Hill, Darren Le Grand, David D. Pascoe, Florence Zink, Christopher Thomson, Andrew Lister, S. Rieffel, David Beattie, Oliver Ross Steward
Publikováno v:
Bioorganicmedicinal chemistry letters. 31
A series of inhibitors of Autotaxin (ATX) have been developed from a high throughput screening hit, 1a, which shows an alternative binding mode to known catalytic site inhibitors. Selectivity over the hERG channel and microsomal clearance were depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e384195e054e5c4b466872e8c04973
https://pubmed.ncbi.nlm.nih.gov/33160025
https://pubmed.ncbi.nlm.nih.gov/33160025
Autor:
Gabi Schutzius, Michael Faller, Aimee Reynolds, Ralph Tiedt, Julia Klopp, Florian Fuchs, Laure C. Bouchez, Federico Tortelli, Nelly Leroy, Jonathan J. Turner, Guglielmo Roma, Simona Cotesta, Armin Beyerbach, Peter Drueckes, Shola M Richards, Debora Bonenfant, Heinrich Rueeger, Heinz Ruffner, Jutta Blank, Rémi Terranova, Peter Tarsa, Frederic Grandjean, Florian Nigsch, Sebastian Bergling, Natalie Dales, Alexandra Aebi, Paul W. Manley, Markus Schirle, Christian Kolter, Tewis Bouwmeester, Rene Hemmig, Sukhdeep Sahambi, Lori L. Jennings, Walter Carbone, Felix Lohmann, Alfred Zimmerlin, Jun Li, Susan Kirkland, Steffen Renner, Mathias Frederiksen, Vickie Driver, Amy Berwick, Florence Zink, Jason R. Thomas, Andrea Vaupel, Chris Dimitri, Vito Guagnano, Viktoria Gruber, Malvina Louis, Caroline Gubser Keller, Adrian Salathe
Publikováno v:
Nature chemical biology. 17(3)
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal barrier by tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a8580afdc9f2d099758e215f9da05e
https://pubmed.ncbi.nlm.nih.gov/33462495
https://pubmed.ncbi.nlm.nih.gov/33462495
Autor:
Nina Ripin, Julien Boudet, Malgorzata M. Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiří Šponer, Nicole C. Meisner-Kober, Frédéric H.-T. Allain
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116 (8)
Proceedings of the National Academy of Sciences of the United States of America, 116 (8)
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3′ untranslated regions, targeting these mRNAs for rapid degradation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7720f9e294b2ac4d90e555d58b530bd3
Publikováno v:
Protein Science. 21:797-808
DGCR8 (DiGeorge Critical Region 8) is an essential microRNA (miRNA) processing protein that recognizes primary transcripts of miRNAs (pri-miRNAs) and triggers their cleavage by the Drosha nuclease. We previously found that Fe(III) heme binds and acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf2b59c7c4c18779f8e33fde1589b1d
https://doi.org/10.1002/pro.2062
https://doi.org/10.1002/pro.2062