Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael F.A. Finley"'
Publikováno v:
ACS Chemical Biology. 14:567-578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d18fa15995102a1c317a3843350cd3
https://doi.org/10.1021/acschembio.9b00169
https://doi.org/10.1021/acschembio.9b00169
Autor:
Ning Qin, Michael F.A. Finley, Christopher M. Flores, Michael P. Neeper, Michael P. Winters, Michael R. Brandt, Wall Mark, Nalin L. Subasinghe, Raymond W. Colburn, Zhihua Sui, Craig R. Schneider, Mary Lou Lubin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3780-3783
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::828824a0e64396bf3c9fd7b0be116b16
https://doi.org/10.1016/j.bmcl.2018.10.007
https://doi.org/10.1016/j.bmcl.2018.10.007
Autor:
Teena M Varghese, Michael F.A. Finley, Samantha J Allen, Paul L. Dudas, Jonathan E Schneeweis
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(1)
Interleukin-23 (IL-23) is a key cytokine implicated in the pathogenesis of autoimmune disorders, including psoriasis and ulcerative colitis. Although targeted IL-23 antibody therapeutics are used clinically, there are no small-molecule therapeutics t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31d677e00fe1099053c8119e05f938
https://pubmed.ncbi.nlm.nih.gov/32484379
https://pubmed.ncbi.nlm.nih.gov/32484379
Autor:
Douglas C. Beshore, Stephen Day, Jason Cassaday, Michelle F. Homsher, Brian Squadroni, David Pechter, Michelle Smith, Lei Ma, Jeffrey D. Hermes, Elizabeth Mohammed, Michelle Hartnett, Paul Zuck, Michael F.A. Finley, Victor N. Uebele, Fredrick Monsma
Publikováno v:
SLAS Discovery. 22:1060-1066
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa4a57a20f8bcde2680cb5a7bfd7c52
https://doi.org/10.1177/2472555217705373
https://doi.org/10.1177/2472555217705373
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058
https://doi.org/10.1177/2472555217706058
Autor:
Bharti Gajera, Albert Rauch, Paul Zuck, Sylvie Jezequel-Sur, Michael F.A. Finley, Jason Cassaday, Jeffrey D. Hermes, Victor N. Uebele, Brian Squadroni
Publikováno v:
SLAS Technology. 22:195-205
In the triage of hits from a high-throughput screening campaign or during the optimization of a lead compound, it is relatively routine to test compounds at multiple concentrations to determine potency and maximal effect. Additional follow-up experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061a421fab1301d8c06fa8e561b2e973
https://doi.org/10.1177/2211068216679805
https://doi.org/10.1177/2211068216679805
Autor:
James I. Fells, Michael F.A. Finley, Wen Feng, Graeme L. Fraser, Xi Ai, Adam B. Weinglass, Ying Lei, Hamid R. Hoveyda, Michelle R. Machacek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127460
Structure- and ligand-based virtual-screening methods (docking, 2D- and 3D-similarity searching) were analyzed for their effectiveness in virtual screening against FFAR2. To evaluate the performance of these methods, retrospective virtual screening w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f64bf151e360bb047749463a394c80
https://doi.org/10.1016/j.bmcl.2020.127460
https://doi.org/10.1016/j.bmcl.2020.127460
Autor:
M. Katharine Holloway, Michael T. Rudd, Michael F.A. Finley, Darrell A. Henze, Kelli Solly, Eric N. Johnson, Rebecca Klein
Publikováno v:
SLAS Discovery. 20:708-719
GluK1, a kainate subtype of ionotropic glutamate receptors, exhibits an expression pattern in the CNS consistent with involvement in pain processing and migraine. Antagonists of GluK1 have been shown to reduce pain signaling in the spinal cord and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23729d0c20b165e295ab2d1b90a41c7
https://doi.org/10.1177/1087057115570580
https://doi.org/10.1177/1087057115570580
Autor:
Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf
https://eprints.gla.ac.uk/146530/1/146530.pdf
Autor:
Matthew Lombardo, Eric N. Johnson, John Cummings, Jerry Di Salvo, Thomas Roussel, James R. Tata, Melissa Kirkland, Michael A. Plotkin, Christopher Joseph Sinz, Feroze Ujjainwalla, Dennis Leung, Dorina Trusca, Joel Mane, Taro E. Akiyama, Alejandro Crespo, Mary Ann Powles, Kate Bender, Michael F.A. Finley, Joanna Pols, Candice Alleyne, Michele Pachanski, Andrew D. Howard, Wayne M. Geissler, Ying Lei, Bahanu Habulihaz, Victor N. Uebele, Clare London, Maria Madeira
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bdf4d7ae8e579647d40689c42f33e
https://pubmed.ncbi.nlm.nih.gov/27815121
https://pubmed.ncbi.nlm.nih.gov/27815121