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pro vyhledávání: '"Michael F. W. Festing"'
Autor:
Michael F. W. Festing
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Scientific Reports
Scientific Reports
Too many pre-clinical experiments are giving results which cannot be reproduced. This may be because the experiments are incorrectly designed. In “Completely randomized” (CR) and “Randomised block” (RB) experimental designs, both the assignme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95487621ef88bc066a0feac147a480bd
http://link.springer.com/article/10.1038/s41598-020-74538-3
http://link.springer.com/article/10.1038/s41598-020-74538-3
Autor:
Michael F W Festing
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112955 (2014)
The safety of chemicals, drugs, novel foods and genetically modified crops is often tested using repeat-dose sub-acute toxicity tests in rats or mice. It is important to avoid misinterpretations of the results as these tests are used to help determin
Externí odkaz:
https://doaj.org/article/4903f64738e04f6392757525061c8de8
Autor:
Michael F. W. Festing
Publikováno v:
Laboratory Animals. 52:341-350
Scientists using laboratory animals are under increasing pressure to justify their sample sizes using a “power analysis”. In this paper I review the three methods currently used to determine sample size: “tradition” or “common sense”, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dc3ab44551c891cf461b4440b89773
https://doi.org/10.1177/0023677217738268
https://doi.org/10.1177/0023677217738268
Autor:
Carol Kilkenny, Nick Parsons, Ed Kadyszewski, Michael F W Festing, Innes C Cuthill, Derek Fry, Jane Hutton, Douglas G Altman
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7824 (2009)
For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained fro
Externí odkaz:
https://doaj.org/article/749a2548e58141568472004a42da03cd
Autor:
Michael F. W. Festing
Publikováno v:
Neuromethods ISBN: 9781493985630
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f238a43f1786220b5abd066820a03585
https://doi.org/10.1007/978-1-4939-8564-7_13
https://doi.org/10.1007/978-1-4939-8564-7_13
Autor:
Timo Nevalainen, Michael F. W. Festing
Publikováno v:
ILAR Journal. 55:379-382
Animal research has made major contributions to the health and welfare of humans and domestic animals. Immunization, first developed against rabies and anthrax by Pasteur using dogs, sheep, and rabbits, is now used to control many infectious diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4624e93dde130c3749edc8708b94fe3f
https://doi.org/10.1093/ilar/ilu046
https://doi.org/10.1093/ilar/ilu046
Autor:
Michael F. W. Festing
Publikováno v:
Toxicologic Pathology. 42:1238-1249
The results of repeat-dose toxicity tests are usually presented as tables of means and standard deviations ( SDs), with an indication of statistical significance for each biomarker. Interpretation is based mainly on the pattern of statistical signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d09abb58914e89e5c638928066220
https://doi.org/10.1177/0192623313517771
https://doi.org/10.1177/0192623313517771
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:200-205
Although rats in various stages of pregnancy are routinely shipped by vendors, the effects of shipping on pregnancy outcomes have not been reported. This study examined the effects of shipping rats 1 day after mating. Two outbred stocks, (Crl:CD(SD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74fb5eec9f25bcd0dfcd4b5755a92384
https://doi.org/10.1002/bdrb.21056
https://doi.org/10.1002/bdrb.21056
Autor:
Michael F W, Festing
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1438
There is growing concern about the poor quality and lack of repeatability of many pre-clinical experiments involving laboratory animals. According to one estimate as much as $28 billion is wasted annually in the USA alone in such studies. A decade ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa3d689fa67fb1c30197d5e0b225084f
https://pubmed.ncbi.nlm.nih.gov/27150081
https://pubmed.ncbi.nlm.nih.gov/27150081
Autor:
Michael F. W. Festing
Publikováno v:
Methods in Molecular Biology ISBN: 9781493936595
There is growing concern about the poor quality and lack of repeatability of many pre-clinical experiments involving laboratory animals. According to one estimate as much as $28 billion is wasted annually in the USA alone in such studies. A decade ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a2fd19bf97b43a6e1335787eed54f4f
https://doi.org/10.1007/978-1-4939-3661-8_1
https://doi.org/10.1007/978-1-4939-3661-8_1