Výsledky vyhledávání - "Michael F. Stone"

Akademický článek

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Autor: Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain

Publikováno v: Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)

Abstract Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl

Externí odkaz: https://doaj.org/article/8353077f8b364edd90a8daf425f335b3

Zobrazit plný text záznamu

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Autor: Jerome Niquet, Caroline R. Schultz, Brenda Marrero-Rosado, Franco Rossetti, Michael F. Stone, Claude G. Wasterlain, Lucille A. Lumley

Publikováno v: Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)
Epilepsia Open

Objective Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b700314b4f4ce5ef649e2f6874642
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3

Zobrazit plný text záznamu

Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam

Autor: Marcio de Araujo Furtado, Brenda Marrero-Rosado, Michael F. Stone, Erica Kundrick, Lucille A. Lumley, Caroline R. Schultz

Publikováno v: Neurotoxicology

Cannabidiol, approved for treatment of pediatric refractory epilepsy, has anti-seizure effects in various animal seizure models. Chemical warfare nerve agents, including soman, are organophosphorus chemicals that can induce seizure and death if untre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e569ee3a5918d2776ec1fc215871b28
https://doi.org/10.1016/j.neuro.2020.12.002

Zobrazit plný text záznamu

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Autor: Katie Walker, Linnzi K.M. Wright, Tsung-Ming Shih, Fu Du, Michael F. Stone, Zora-Maya Keith, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Kimberly A. Whitten, Cindy Acon-Chen

Publikováno v: Toxicology Reports, Vol 8, Iss, Pp 896-907 (2021)
Toxicology Reports

Graphical abstract
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757661aa0cf9bbfbadc91ef4471049fd
http://www.sciencedirect.com/science/article/pii/S2214750021000810

Zobrazit plný text záznamu

Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice

Autor: Robyn B. Lee-Stubbs, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Marcio de Araujo Furtado, Erica Kundrick, Michael F. Stone, Katie Walker

Publikováno v: Ann N Y Acad Sci

Chemical warfare nerve agent exposure leads to status epilepticus (SE) that may progress to epileptogenesis and severe brain pathology when benzodiazepine treatment is delayed. We evaluated the dose–response effects of delayed midazolam on toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5368ac9f2f25277a9abddfcf1f3bb06
https://doi.org/10.1111/nyas.14311

Zobrazit plný text záznamu

Plný text ve formátu HTML

Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long‐term effects of whole‐body sarin exposure in rats

Autor: J.M. McGuire, Lucille A. Lumley, William T. Muse, Dennis B. Miller, Christopher E. Whalley, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Michael F. Stone

Publikováno v: Epilepsia Open
Epilepsia Open, Vol 4, Iss 3, Pp 382-396 (2019)

Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0490527ae3e6eb1e7e36901e7404b5de
http://europepmc.org/articles/PMC6698686

Zobrazit plný text záznamu

Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice

Autor: Brenda Marrero-Rosado, Michael F. Stone, Lucille A. Lumley, C. Linn Cadieux, Caroline R. Schultz, Marcio de Araujo Furtado

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 1893, p 1893 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 4

The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is dependent on the choice of animal model used in preclinical studies. CWNAs bind to acetylcholi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53550536bbd1ed3c06f07be15197820
https://www.mdpi.com/1422-0067/22/4/1893

Zobrazit plný text záznamu

Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice

Autor: Brenda Marrero-Rosado, Katie Walker, Erica Kundrick, Lucille A. Lumley, Marcio de Araujo Furtado, Michael F. Stone, Donna A. Nguyen, Caroline R. Schultz

Publikováno v: Epilepsy Behav

Delayed treatment of cholinergic seizure results in benzodiazepine-refractory status epilepticus that is thought, at least in part, to result from maladaptive trafficking of N-methyl-D-aspartate (NMDA) and gamma aminobutyric acid type A (GABA(A)) rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37affbd8a5a3bf3d5b96664096f3513
https://doi.org/10.1016/j.yebeh.2020.107229

Zobrazit plný text záznamu

Autor: Michael F. Stone, Mark C Moffett, Franco Rossetti, Brenda Marrero-Rosado, Lucille A. Lumley, Matthew W. Rice, Robyn B. Lee

Elderly individuals compose a large percentage of the world population; however, few studies have addressed the efficacy of current medical countermeasures (MCMs) against the effects of chemical warfare nerve agent exposure in aged populations. We ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906ca7ac61d530715dec9733b5bd642d
https://europepmc.org/articles/PMC6016615/

Zobrazit plný text záznamu

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam

Autor: Michael F. Stone, Lucille A. Lumley, Brenda Marrero-Rosado, Caroline R. Schultz, Erica Kundrick, Katie Walker, Marcio de Araujo Furtado, Fu Du, Sean O'Brien

Publikováno v: Epilepsia

Summary Objective Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8d434991ebc4a081a28c8d74e912b5
https://pubmed.ncbi.nlm.nih.gov/30368799

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání