Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Michael F. Scully"'
Autor:
Michael F. Scully
In recent years, there has been an upsurge in interest in'roots music'and'world music,'popular forms that fuse contemporary sounds with traditional vernacular styles. In the 1950s and 1960s, the music industry characterized similar sounds simply as'f
Publikováno v:
Cancer Biology & Therapy. 15:135-145
A major problem in cancer treatment is the development of resistance to chemotherapeutic agents, multidrug resistance (MDR), associated with increased activity of transmembrane drug transporter proteins which impair cytotoxic treatment by rapidly rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf61cce5bacacab80758eec876c7d88
https://doi.org/10.4161/cbt.27148
https://doi.org/10.4161/cbt.27148
Autor:
Michael F. Scully, Christopher A. Goodwin, Min Xia, Xinjie Lu, Ajay K. Kakkar, Gloria Dawson, Yunliang Chen
Publikováno v:
Thrombosis and Haemostasis. 109:1148-1157
SummaryHeparansulfate-proteoglycans (HSPGs) interact via their polyanionic heparansulfate (HS) side chains with a variety of proteins on the cell surface or within the extracellular matrix membrane. The large number of heparin/HS binding proteins for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38baf670750a9b366c8d8776864af805
https://doi.org/10.1160/th12-12-0935
https://doi.org/10.1160/th12-12-0935
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 6:579-587
Thromboembolic events contribute significantly to the morbidity and mortality in cancer. Effective and safe anticoagulation - mainstay in prevention and treatment of thrombosis - remains very challenging clinical task in oncology patients - populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418d9e0bf083b9f0acf5a132c00c058c
https://doi.org/10.2174/187152006778699112
https://doi.org/10.2174/187152006778699112
In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry
Autor:
Michael F. Scully, Ricardo Morilla, Hugh F. Paterson, Ian Titley, Vijay V. Kakkar, Derek Davies, Alicja M. Gruszka-Westwood, Milena A. Gebska, Suzanne A. Eccles
Publikováno v:
Blood. 99:2221-2227
During cell death of human cultured leukocytes (Jurkat, HL-60, THP-1, U937) and freshly prepared leukocytes, we observed a greater than 100-fold increase in the affinity of apoptotic and necrotic cells for fluorescein isothiocyanate (FITC)-heparin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5371b398cb8e2afec18c4bacca34863
https://doi.org/10.1182/blood.v99.6.2221
https://doi.org/10.1182/blood.v99.6.2221
Publikováno v:
Thrombosis and Haemostasis. 87:523-529
Summary15 deoxy Δ12,14 PGJ2 (15d-PGJ2), a high affinity ligand of peroxisome proliferator-activated receptor γ (PPAR γ has been proposed to act as a negative feedback regulator of the inflammatory response. We investigated the effect of 15d-PGJ2 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bfcad8b5e2e33f92752fe26f0ea0c9d
https://doi.org/10.1055/s-0037-1613034
https://doi.org/10.1055/s-0037-1613034
Autor:
Emmanuel Skordalakes, Harry R. Hudson, G.G. Dodson, Donovan Green, John Deadman, Vijay V. Kakkar, Christopher A. Goodwin, Michael F. Scully
Publikováno v:
Journal of Molecular Biology. 311:549-555
X-ray crystallographic studies of human α-thrombin with a novel synthetic inhibitor, an acyl (α-aminoalkyl)phosphonate, reveal the existence of a pentacovalent phosphorus intermediate state. Crystal structures of the complex of α-thrombin with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ed4ba19dacfd772bbed3ad89c3e42b3
https://doi.org/10.1006/jmbi.2001.4872
https://doi.org/10.1006/jmbi.2001.4872
Publikováno v:
Thrombosis and Haemostasis. 86:616-622
SummaryWe have observed a striking neutralisation of the anticoagulant activity of unfractionated heparin in the presence of a pancreatic carcinoma cell line (MIA PaCa-2) due to binding of around 9 g of heparin per 107 cells (apparent Kd, 30 nM). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d63e8f42b581a89ca4619c14c6041ec4
https://doi.org/10.1055/s-0037-1616095
https://doi.org/10.1055/s-0037-1616095
Autor:
Emmanuel Skordalakes, John Deadman, Jean-Marie Freyssinet, Said Elgendy, Michael F. Scully, Donovan Green, Guy Dodson, Vijay V. Kakkar, Christopher A. Goodwin
Publikováno v:
Biochemistry. 37:14420-14427
The affinity of the hirudin49-64 segment for exosite 1 of thrombin has been used previously to enhance the potency of simple competitive inhibitors [DiMaio, J., Gibbs, B., Munn, D., Lefebvre, J. , Ni, F., Konishi, Y. (1990) J. Biol. Chem. 265, 21698-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9017e12925542be89801b10e67b961c5
https://doi.org/10.1021/bi980225a
https://doi.org/10.1021/bi980225a