Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael F. Saikali"'
Autor:
Cigdem Sahin, Jenna-Rose Melanson, Florian Le Billan, Lilia Magomedova, Thais A.M. Ferreira, Andressa S. Oliveira, Evan Pollock-Tahari, Michael F. Saikali, Sarah B. Cash, Minna Woo, Luiz A.S. Romeiro, Carolyn L. Cummins
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101958- (2024)
Objective: The prevalence of metabolic diseases is increasing globally at an alarming rate; thus, it is essential that effective, accessible, low-cost therapeutics are developed. Peroxisome proliferator-activated receptors (PPARs) are transcription f
Externí odkaz:
https://doaj.org/article/cfebdf9a904b44948be866fb0310321e
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Idit Dotan, Jiaqi Yang, Jiro Ikeda, Ziv Roth, Evan Pollock-Tahiri, Harsh Desai, Tharini Sivasubramaniyam, Sonia Rehal, Josh Rapps, Yu Zhe Li, Helen Le, Gedaliah Farber, Edouard Alchami, Changting Xiao, Saraf Karim, Marcela Gronda, Michael F. Saikali, Amit Tirosh, Kay-Uwe Wagner, Jacques Genest, Aaron D. Schimmer, Vikas Gupta, Mark D. Minden, Carolyn L. Cummins, Gary F. Lewis, Clinton Robbins, Jenny Jongstra-Bilen, Myron Cybulsky, Minna Woo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Loss of myeloid JAK2 promotes atherosclerosis in an ApoE knockout mouse model. This is associated with decreased cholesterol efflux from bone-marrow-derived macrophages.
Externí odkaz:
https://doaj.org/article/8f5bbf65f53546318be8781e62cd0a46
Autor:
Adil Rasheed, Sarah A. Shawky, Ricky Tsai, Richard G. Jung, Trevor Simard, Michael F. Saikali, Benjamin Hibbert, Katey J. Rayner, Carolyn L. Cummins
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 479-491 (2021)
Abstract Endothelial progenitor cells (EPCs) promote the maintenance of the endothelium by secreting vasoreparative factors. A population of EPCs known as early outgrowth cells (EOCs) is being investigated as novel cell‐based therapies for the trea
Externí odkaz:
https://doaj.org/article/3046695fb43846b1836880d2cf1f986b
Autor:
Laura L Gathercole, Nikolaos Nikolaou, Shelley E Harris, Anastasia Arvaniti, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, Jeremy W Tomlinson
Publikováno v:
Journal of Endocrinology. 253:97-113
Steroid 5β-reductase (AKR1D1) plays important role in hepatic bile acid synthesis and glucocorticoid clearance. Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. Akr1d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9778b5b1fbb3dbdd7f97861c4fc255
https://doi.org/10.1530/joe-21-0280
https://doi.org/10.1530/joe-21-0280
Autor:
Sydney Currier, Amila Omeragic, David J. Volsky, Reina Bendayan, Michael F. Saikali, Carolyn L. Cummins
Publikováno v:
The FASEB Journal. 34:1996-2010
Despite the use of antiretroviral therapy for the treatment of HIV-1 infection, cognitive impairments, that is, HIV-1-associated neurocognitive disorders remain prevalent potentially due to persistent viral replication, production of viral proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2e11e8b2ae5ccd177882cae73fc011
https://doi.org/10.1096/fj.201901874r
https://doi.org/10.1096/fj.201901874r
Autor:
Fabio Sanna, Laura Gathercole, Conceicao Ismael da, Anastasia Arvaniti, Niall Dempster, Carolyn L. Cummins, Michael F. Saikali, Jeremy Tomlinson, Nikolaos Nikolaou
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3aff4af0ac99c650a76dbd882e82b6e
https://doi.org/10.1530/endoabs.77.p43
https://doi.org/10.1530/endoabs.77.p43
Autor:
Sayeepriyadarshini Anakk, Kannanganattu V. Prasanth, Gene W. Yeo, Ullas V. Chembazhi, Carolyn L. Cummins, Steven M. Blue, Michael F. Saikali, Qinyu Hao, Van Nostrand El, Bhoomika Mathur, Brian A. Yee, Waqar Arif, Sushant Bangru, Auinash Kalsotra
Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4ad0652a65921864401be82090dd34
https://doi.org/10.1101/2021.07.10.451875
https://doi.org/10.1101/2021.07.10.451875
Autor:
Florian Le Billan, Stephane Angers, Mélanie Robitaille, Henry M. Krause, Quaid Morris, Carolyn L. Cummins, Debashish Ray, Vincent Boivin, Timothy P. Hughes, Benjamin J. Blencowe, Michelle S. Scott, Serge Gueroussov, Rucha Patel, Michael F. Saikali, Lilia Magomedova, Chao Xu, Emma Zilberman, Jens Tiefenbach, Pancharatnam Jeyasuria, Veronique Voisin, Gary D. Bader, Manuel Irimia
Publikováno v:
Nucleic Acids Research
Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modulators of glucocorticoid signaling in the CNS. Biochemical studies sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6765dcec4b6840322a957c405a3541
http://europepmc.org/articles/PMC6451108
http://europepmc.org/articles/PMC6451108
Autor:
Trevor M. Penning, Laura Gathercole, Michael F. Saikali, Kratschmar Dv, Shelley Harris, Roger D. Cox, Ahmad Moolla, Jonathan Hazlehurst, Liz Bentley, Ryan C. Pink, Jeremy W. Tomlinson, Toryn Poolman, Nikolaos Nikolaou, Niall Dempster, Alex Odermatt, Claes Ohlsson, Matti Poutanen, Anastasia Arvaniti, Carolyn L. Cummins, Marijana Todorčević
BackgroundSteroid 5β-reductase (AKR1D1) plays important roles in hepatic glucocorticoid clearance and bile acid synthesis. Glucocorticoids and bile acids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b696683522dd09fab5fd3b09f895111
https://doi.org/10.1101/2021.02.02.429227
https://doi.org/10.1101/2021.02.02.429227